Results 251 to 260 of about 86,546 (282)

Senolytics and exercise: Dual modalities for rejuvenating muscle

The Journal of Physiology, EarlyView.
Abstract figure legend The role of senolytics on the heart and skeletal muscle. Senescent cell burden increases with ageing, disuse and disease. The senolytics dasatinib+quercetin (D+Q), navitoclax and fisetin, as well as exercise, eliminate senescent cells, reducing senescent cell burden and their senescence‐associated secretory phenotype (SASP ...
Zeynep Elif Yesilyurt‐Dirican, Ce Qi, Uchenna Okpechi, Maya Strand Ford, Georgina M. Ellison‐Hughes   +4 more
wiley   +1 more source

Targeting chemokine signaling networks for therapeutics in skeletal disorders. [PDF]

Front Endocrinol (Lausanne)
Gao W, Gao Z, Chen Y, Wang Y, Li Y, Qian Y, Lu H, Ling X, Xiao H, Yang P, Qiao Y.   +10 more
europepmc   +1 more source

Inflammatory Mediators Both Directly and Indirectly Promote Microglial Proliferation

Glia, Volume 74, Issue 5, May 2026.
– CSF2, IL3, and TNFɑ directly promote microglial proliferation. – Neuron‐secreted factors suppress microglial proliferation. – IL1 cytokines promote CSF2 release from astrocytes, which promotes microglial proliferation. ABSTRACT Microglia—the predominant immune cell of the central nervous system (CNS)—possess an astounding capacity for proliferation ...
Brady P. Hammond, Eugene Hahn, Kelly V. Lee, Bradley J. Kerr, Jason R. Plemel   +4 more
wiley   +1 more source

Unveiling CCL2 and CXCL1: Key biomarkers and therapeutic targets in idiopathic pulmonary fibrosis. [PDF]

Sarcoidosis Vasc Diffuse Lung Dis
Pan J, Li G, Pu Y, Li P, Zhou Y.
europepmc   +1 more source

Genomic and Immune Correlates of EZH2 Expression and Activity in Olfactory Neuroblastoma

Head &Neck, Volume 48, Issue 4, Page 932-940, April 2026.
ABSTRACT Purpose Olfactory neuroblastoma (ONB) is a rare sinonasal malignancy with limited therapeutic options in the recurrent/metastatic setting; little is known regarding its responsiveness to immunotherapy. Inhibition of enhancer of zeste homolog 2 (EZH2) has been shown to improve T‐cell‐mediated killing and susceptibility to immune checkpoint ...
Elisabetta Xue, Tolulope Adeyelu, Harris Krause, Andrew Elliott, Ranee Mehra, Heloisa Soares, Emil Lou, Ari Vanderwalde, David Spetzler, Dara Bracken‐Clarke, Nyall R. London Jr., James L. Gulley, Charalampos S. Floudas   +12 more
wiley   +1 more source

Nucleic acid-induced chemokine expression in keratinocytes: Implications for skin inflammation. [PDF]

PLoS One
Danis J, Kelemen E, Balogh F, Szabó K, Fodor GH, Ádám É, Széll M.   +6 more
europepmc   +1 more source

Comprehensive genomic profiling of triple-negative breast cancer metastases identifies role of PKD1 in immunotherapy resistance. [PDF]

J Clin Invest
Zhu XZ, Zhou YF, Ying XH, Wang YY, Ding XH, Zhang KY, Shao ZM, Jin X, Jiang YZ, Wang ZH.   +9 more
europepmc   +1 more source

Are Peripartum Changes in CCL2 Associated with Maternal Metabolic Status? [PDF]

Curr Issues Mol Biol
Obuchowska-Standyło A, Kimber-Trojnar Ż, Trojnar K, Czuba M, Leszczyńska-Gorzelak B.   +4 more
europepmc   +1 more source