Results 61 to 70 of about 86,546 (282)
Importance of chemokine (CC-motif) ligand 2 in breast cancer
The International Journal of Biological Markers, 2012 Breast cancer is the leading cause of cancer-related death in women in the United States. Chemokine (CC-motif) ligand 2 (CCL2), an inflammatory cytokine and chemokine, is highly expressed within the tumor and stromal cell populations and has been ...
Jennifer L. Steiner +1 more
doaj +1 more source
Expression Changes of Serum IL-1α, CCL2, and CXCL2 in Patients With Pemphigus
International Journal of Dermatology and Venerology, 2023 Objective:. This study was performed to explore the possible changes of the serum levels of the cytokines including interleukin 1α (IL-1 α), chemokine monocyte chemotactic protein 1 (also known as chemokine [C-C motif] ligand 2 [CCL2]), and C-X-C motif ...
Li-Dan Mao +5 more
doaj +1 more source
Experimental Eye Research, 2013 Monocytes, macrophages, dendritic cells and microglia play critical roles in the local immune response to acute and chronic tissue injury and have been implicated in the pathogenesis of age-related macular degeneration. Defects in Ccl2-Ccr2 and Cx3cl1-Cx3cr1 chemokine signalling cause enhanced accumulation of bloated subretinal microglia/macrophages in
Luhmann, Ulrich F.O. +7 more
openaire +2 more sources
CCL2, CCL8, CXCL12 chemokines in resectable non-small cell lung cancer (NSCLC)
Biomedical Papers, 2023 Complex networks of chemokines are part of the immune reaction targeted against tumor cells. Chemokines influence cancer growth. It is unclear whether the concentrations of chemokines at the time of NSCLC (non-small cell lung cancer) diagnosis differ from healthy controls and reflect the extent of NSCLC.To compare chemokine concentrations (CCL2, CCL8 ...
Marie Drosslerova +8 more
openaire +3 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis [PDF]
, 2011 Macrophages abundantly found in the tumor microenvironment enhance malignancy(1). At metastatic sites a distinct population of metastasis associated macrophages (MAMs) promote tumor cell extravasation, seeding and persistent growth(2).
AB Al-Mehdi +32 more
core +2 more sources
Genetic variants of chemokine CCL2 and chemokine receptor CCR2 genes and risk of prostate cancer
Tumor Biology, 2014 Chemokines and their receptors acts as mediators of migration of immune cells to the site of inflammation and deregulated inflammatory response is associated with increased risk of cancer. We performed a case-control study to analyze the frequencies of CCL2 (I/D, rs3917887), -2518 (A > G, rs1024611), and CCR2 (G > A, rs1799864) polymorphisms for ...
Raju K, Mandal +2 more
openaire +2 more sources
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
Folia Histochemica et Cytobiologica, 2011 The migration, survival and proliferation of cells is the basis for all physiologic and pathologic processes in the human body. All these reactions are regulated by a complex chemokine network that guides lymphocytes homing, chemotaxis, adhesion and ...
Kazimierz Kuliczkowski +7 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Our previous study found that Notch3 knockout mice exhibit defects in mammary gland development. To elucidate the underlying mechanism, tissue samples were subjected to RNA-seq, GO, and KEGG enrichment analyses and qRT-PCR validation.
Wei Xiong +6 more
doaj +1 more source