Results 1 to 10 of about 3,348 (111)

Anserine/Carnosine Supplementation Suppresses the Expression of the Inflammatory Chemokine CCL24 in Peripheral Blood Mononuclear Cells from Elderly People [PDF]

Nutrients, 2017
Our goal was to determine whether anserine/carnosine supplementation (ACS) suppresses chemokine levels in elderly people. In a double-blind randomized controlled trial, volunteers were assigned to the ACS or placebo group (1:1). Sixty healthy elderly volunteers (active, n = 30; placebo, n = 30) completed the study.
Hiroshi Matsuda, Tatsuhiro Hisatsune, Yoshinori Katakura   +2 more
exaly   +4 more sources

CCL24 and Fibrosis: A Narrative Review of Existing Evidence and Mechanisms [PDF]

Cells
Tissue fibrosis results from a dysregulated and chronic wound healing response accompanied by chronic inflammation and angiogenesis. Regardless of the affected organ, fibrosis shares the following common hallmarks: the recruitment of immune cells ...
Chris Weston, Raanan Greenman
exaly   +4 more sources

A blocking monoclonal antibody to CCL24 alleviates liver fibrosis and inflammation in experimental models of liver damage

JHEP Reports, 2020
Background & Aims: C-C motif chemokine ligand 24 (CCL24) is a chemokine that regulates inflammatory and fibrotic activities through its receptor, C-C motif chemokine receptor (CCR3).
Scott Friedman, , Dan Haberman
exaly   +3 more sources

Inflammatory Mediators of Alzheimer’s Disease Characterized in a Mouse Model (APP/PS1) [PDF]

NeuroSci
Alzheimer’s disease (AD) is marked by amyloid plaques, hyperphosphorylated TAU proteins, and neuroinflammation. The APP/PS1 mouse model is widely used to study AD pathogenesis.
Adrian Jorda, Kenia Alvarez-Gamez, Ignacio Campo-Palacio, Juan Campos-Campos, Carlos Colmena, Sandeep Kumar Singh, Maria Jose Chiva Miralles, Constanza Aldasoro, Martin Aldasoro, Soraya L. Valles   +9 more
doaj   +2 more sources

Pollutant particles enhance house dust mite induced type 2 inflammation and the recruitment of monocyte derived Cd11c+ Gpnmb+ macrophages to the airway lumen [PDF]

Particle and Fibre Toxicology
Background Air pollution particles exacerbate allergic asthma and can enhance inflammatory responses to allergen exposure, but the cellular mechanisms involved remain incompletely defined. We examined how diesel exhaust particles (DEP) enhance house-dust-
Kirsty Meldrum, Ayokulehin Muse Kosoko, Martin Oliver Leonard   +2 more
doaj   +2 more sources

Peritoneal MSCs-derived exosomes suppress CCL24 synthesis through miR-320d delivery contributing to the improvement of peritoneal dialysis-associated fibrosis [PDF]

Scientific Reports
Mesothelial-to-mesenchymal transition (MMT) is a key pathological process driving peritoneal fibrosis in patients undergoing peritoneal dialysis (PD).
Xinhui Zhao, Minhui Xi, Hualin Qi, Jia Xu, Rui Yuan, Danye Shi, Jingyuan Lu   +6 more
doaj   +2 more sources

CCL24 regulates biliary inflammation and fibrosis in primary sclerosing cholangitis

JCI Insight, 2023
ˆCCL24 is a pro-fibrotic, pro-inflammatory chemokine expressed in several chronic fibrotic diseases. In the liver, CCL24 plays a role in fibrosis and inflammation, and blocking CCL24 led to reduced liver injury in experimental models. We studied the role
Francesca Saffioti, Douglas Thorburn
exaly   +2 more sources

CXCL12 and CXCL13 as potential biomarkers for disease severity and recurrence in respiratory syncytial virus bronchiolitis [PDF]

Scientific Reports
To examine chemokine expression in children with Respiratory Syncytial Virus (RSV) bronchiolitis and evaluate its clinical utility for early warning and prognosis. Five hospitalised RSV bronchiolitis children and five matched controls were studied.
Lin Zhang, Yuanyu Lv, Zhiao Du, Jiawei Chen, Peng Mo, Xuena Xu, Huiming Sun, Yongdong Yan, Canhong Zhu, Li Huang, Chuangli Hao, Xiuxia Zhou, Heting Dong, Zhengrong Chen   +13 more
doaj   +2 more sources

Millettia speciosa reprograms the lung proteome and suppresses CCL24-driven eosinophilic inflammation in allergic asthma [PDF]

Frontiers in Allergy
BackgroundAsthma is a Th2-skewed inflammatory disorder characterized by eosinophilic infiltration, cytokine dysregulation, and airway remodeling.
Hangrui Yang, Geyuan Wu, Shuo Liang, Raona Zan, Yitao Chen, Weiwei Yuan, Hong Chen, Guiqiong Huang   +7 more
doaj   +2 more sources

The Role of CCL24 in Primary Sclerosing Cholangitis: Bridging Patient Serum Proteomics to Preclinical Data

Cells
Primary sclerosing cholangitis (PSC) is an inflammatory and fibrotic biliary disease lacking approved treatment. We studied CCL24, a chemokine shown to be overexpressed in damaged bile ducts, and its involvement in key disease-related mechanisms.
Francesca Saffioti, Raanan Greenman, Matthew Frankel   +2 more
exaly   +3 more sources