Results 91 to 100 of about 49,554 (304)

New AMD3100 derivatives for CXCR4 chemokine receptor targeted molecular imaging studies: synthesis, anti-HIV-1 evaluation and binding affinities [PDF]

, 2015
CXCR4 is a target of growing interest for the development of new therapeutic drugs and imaging agents as its role in multiple disease states has been demonstrated.
Archibald, Stephen J., Boschetti, Frederic, Boschetti, Frédéric, Cawthorne, Christopher, D'huys, Thomas, Denat, Franck, Desogere, Pauline, Désogère, Pauline, Désogère, Pauline, D‘huys, Thomas, Goze, Christine, Maecke, Helmut R., Maëcke, Helmut R., Poty, Sophie, Schols, Dominique   +14 more
core   +1 more source

Polymorphism and circulating levels of the chemokine CXCL12 in colorectal cancer patients

International Journal of Molecular Medicine, 2007
The chemokine CXCL12, also known as stromal cell-derived factor-1 (SDF-1), is a small protein that regulates leukocyte trafficking and is variably expressed in a number of normal and cancer tissues. CXCL12 as ligand and its receptor CXCR4 have been implicated in colorectal cancer (CRC) progression including angiogenesis and metastasis.
Jan Dimberg, Anders Hugander, Sture Löfgren, Dick Wågsäter   +3 more
openalex   +5 more sources

Nuclear Factor I‐B Delays Liver Fibrosis by Inhibiting Chemokine Ligand 5 Transcription

Advanced Science, EarlyView.
This study identifies the transcription factor Nuclear Factor I‐B (NFIB) as a key suppressor of liver fibrosis. NFIB expression declines during hepatic stellate cell activation, and its overexpression reduces fibrosis in mice models. The mechanism involves NFIB directly repressing chemokine C─C motif ligand 5 (CCL5), thereby alleviating oxidative ...
Qianqian Chen, Fajuan Rui, Zhiwen Fan, Hongju Yang, Nan Geng, Chenqi Lu, Wenjing Ni, Yue Huan, Junping Shi, Chao Wu, Shengxia Yin, Wei An, Xia Lu, Qianwen Zhao, Jie Li   +14 more
wiley   +1 more source

Dasatinib inhibits CXCR4 signaling in chronic lymphocytic leukaemia cells and impairs migration towards CXCL12 [PDF]

, 2012
Chemokines and their ligands play a critical role in enabling chronic lymphocytic leukaemia (CLL) cells access to protective microenvironmental niches within tissues, ultimately resulting in chemoresistance and relapse: disruption of these signaling ...
A Hochhaus, A Ptasznik, A Serrels, A Veldurthy, AC Shor, Alison M. McCaig, Alison M. Michie, AM McCaig, CD Allen, CM Pleiman, DY Hallaert, Emilio Cosimo, J Hoellenriegel, J Hoellenriegel, JA Burger, JA Burger, JA Burger, JW Friedberg, LJ Lombardo, M Buchner, M Burger, M Lopez-Guerra, M Niedermeier, M O'Hayre, MF de Rooij, Michael T. Leach, MP Quiroga, O Hantschel, P Ghia, PC Amrein, R Buettner, RE Hayden, S Braselmann, S Ponader, S Willimott, SJ Richardson, Spencer B. Gibson, Y Nakata, Z Song   +38 more
core   +6 more sources

Involvement of the CXCL12 System in the Stimulatory Effects of Prenatal Exposure to High-Fat Diet on Hypothalamic Orexigenic Peptides and Behavior in Offspring

Frontiers in Behavioral Neuroscience, 2017
Exposure to a high fat diet (HFD) during gestation stimulates neurogenesis and expression of hypothalamic orexigenic neuropeptides that affect consummatory and emotional behaviors.
Kinning Poon, Jessica R. Barson, Jessica R. Barson, Huanzhi Shi, Guo Qing Chang, Sarah F. Leibowitz   +5 more
doaj   +1 more source

CXCL12 retargeting of an adenovirus vector to cancer cells using a bispecific adapter [PDF]

, 2016
Ad vectors are promising delivery vehicles for cancer therapeutic interventions. However, their application is limited by promiscuous tissue tropism and hepatotoxicity. This limitation can be avoided by altering the native tropism of Ads so that they can
Bhatia, Shilpa, Curiel, David T, Mathis, J. Michael, O\u27Bryan, Samia M, Rivera, Angel A   +4 more
core   +3 more sources

⁠Engineering Adaptive Immunity in 3D: A Patient‐Specific Lymphoid Model Using Stromal Networks and Peripheral Blood Mononuclear Cells

Advanced Science, EarlyView.
This study presents a 3D lymphoid tissue model engineered from adipose‐derived stem cells differentiated into fibroblastic reticular cell–like networks and co‐cultured with immune cells. The engineered system successfully generates antigen‐specific antibodies and cytokine responses, providing a platform for studying adaptive immunity, vaccine efficacy,
Mei ElGindi, Shaza Karaman, Jeremy Teo
wiley   +1 more source

The novel chemokine receptor CXCR7 regulates trans-endothelial migration of cancer cells

Molecular Cancer, 2011
Background Migration of metastatic tumor cells from the bloodstream into lymph nodes is thought to be facilitated by expression of the chemokine receptors CCR7, CXCR4 and, for B cell-derived tumors, CXCR5. Expression of their respective chemokine ligands
Jaén Juan C, Berahovich Robert D, Lewén Susanna, Zabel Brian A, Schall Thomas J   +4 more
doaj   +1 more source

Supplementary Tables 1-2 from The CXCL12–CXCR4 Chemokine Pathway: A Novel Axis Regulates Lymphangiogenesis [PDF]

, 2023
Zhuo Wei, Lin Jia, Nan Song, Xin‐an Lu, Yanping Ding, Xiaofeng Wang, Xiaomin Song, Yan Fu, Yongzhang Luo   +8 more
openalex   +1 more source

IL4I1⁺ Macrophages and TDO2⁺ Myofibroblasts Drive AhR‐Mediated Immunosuppression and Ferroptosis Resistance in Solid Predominant Lung Adenocarcinoma

Advanced Science, EarlyView.
Solid predominant lung adenocarcinoma exhibits an immune‐excluded, ferroptosis‐resistant niche enriched with IL4I1⁺ TAMs and TDO2⁺ myCAFs. Spatial and multi‐omics analyses reveal AhR‐driven crosstalk that promotes T cell exhaustion and therapy resistance. Blocking AhR with CH‐223191 restores ferroptosis sensitivity, and its combination with ferroptosis
Zhaoxuan Wang, Weijiao Xu, Lei Zhao, Lin Zhong, Wendan Yu, Shengmin Wang, Lu Sun, Tao Guo, Fengzhou Li, Zhuoshi Li, Lei Fang, Shiqing Wang, Guohui Zhang, Guoqing Xue, Wei Guo, Shilei Zhao, Chundong Gu   +16 more
wiley   +1 more source