Results 81 to 90 of about 48,772 (164)

Concepts of GPCR-controlled navigation in the immune system

, 2019
G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L, Brandt SL, Chan EC, Filippo K, Freedman NJ, Hjorto GM, Hons M, Katakai T, Kitayama J, Lemos C, Ley K, Miyabe Y, Moussavi‐Harami SF, Proudfoot AEI, Purvanov V, Rot A, Scheiermann C, Schwarz J, Sokol CL, Sotsios Y, Steury MD, Takeda A, Thiriot A, Tomhave ED, Wang Y, Yanagihara S, Zhang Y   +26 more
core   +1 more source

Chemokine CXCL12 drives pericyte accumulation and airway remodeling in allergic airway disease. [PDF]

Respir Res, 2022
Bignold R, Shammout B, Rowley JE, Repici M, Simms J, Johnson JR.   +5 more
europepmc   +1 more source

The chemokine receptor CXCR4 and its ligand CXCL12 are activated during implantation and placentation in sheep [PDF]

, 2011
Background The progression of implantation and placentation in ruminants is complex and is regulated by interplay between sex steroids and local signaling molecules, many of which have immune function.
Ryan L Ashley, Alfredo Q Antoniazzi, Russell V Anthony, Thomas R Hansen   +3 more
core   +2 more sources

Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12. [PDF]

ACS Med Chem Lett, 2021
Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC.   +4 more
europepmc   +1 more source

CXCL14 antagonizes the CXCL12-CXCR4 signaling axis

Biomolecular Concepts, 2014
CXCL12 and CXCL14 are evolutionarily conserved members of the CXC-type chemokine family. CXCL12 binds specifically to the G-protein-coupled receptor CXCR4 to induce the migration of primordial germ cells, hematopoietic stem cells, and inflammation ...
Hara Takahiko, Tanegashima Kosuke
doaj   +1 more source

Mechanisms of HIV-1 evasion to the antiviral activity of chemokine CXCL12 indicate potential links with pathogenesis. [PDF]

PLoS Pathog, 2021
Armani-Tourret M, Zhou Z, Gasser R, Staropoli I, Cantaloube-Ferrieu V, Benureau Y, Garcia-Perez J, Pérez-Olmeda M, Lorin V, Puissant-Lubrano B, Assoumou L, Delaugerre C, Lelièvre JD, Lévy Y, Mouquet H, Martin-Blondel G, Alcami J, Arenzana-Seisdedos F, Izopet J, Colin P, Lagane B.   +20 more
europepmc   +1 more source

Crosstalk between astrocytic CXCL12 and microglial CXCR4 contributes to the development of neuropathic pain [PDF]

, 2016
published_or_final_versio
Cheung, CW, Chung, SK, Luo, X, Pan, Z, Sun, LT, TAI, WL, Xia, Z   +6 more
core   +1 more source

Involvement of CXCL12/CXCR4 in CB2 receptor agonist-attenuated morphine tolerance in Walker 256 tumor-bearing rats with cancer pain

European Journal of Medical Research
While low-dose cannabinoid 2 (CB2) receptor agonists attenuate morphine tolerance in cancer pain models, chemokine ligand 12 (CXCL12)/chemokine receptor 4 (CXCR4) expression induces morphine tolerance.
Dandan Liu, Mingyue Zhang, Xiaohai Xu, Xuelai Zhong, Chao Ma, Xiaoyu Zheng, Xiaohong Wu, Guonian Wang   +7 more
doaj   +1 more source

Dose‐dependent Effect of Statin Therapy on Circulating CXCL12 Levels in Patients with Hyperlipidemia

Clinical and Translational Medicine, 2012
Background HMG‐CoA reductase inhibitors (statins) have pleiotropic effects that are independent of cholesterol‐lowering, including a dose‐dependent effect on angiogenesis.
Will Camnitz, Marie D Burdick, Robert M Strieter, Borna Mehrad, Ellen C Keeley   +4 more
doaj   +1 more source

Elevated plasma CXCL12 leads to pain chronicity via positive feedback upregulation of CXCL12/CXCR4 axis in pain synapses

The Journal of Headache and Pain
Background Chronic pain poses a clinical challenge due to its associated costly disability and treatment needs. Determining how pain transitions from acute to chronic is crucial for effective management.
Shi-Ze Leng, Mei-Jia Fang, Yi-Min Wang, Zhen-Jia Lin, Qian-Yi Li, Ya-Nan Xu, Chun-Lin Mai, Jun-Ya Wan, Yangyinhui Yu, Ming Wei, Ying Li, Yu-Fan Zheng, Kai-Lang Zhang, Ya-Juan Wang, Li-jun Zhou, Zhi Tan, Hui Zhang   +16 more
doaj   +1 more source