A guide to chemokines and their receptors [PDF]
The FEBS Journal, 2018 The chemokines (or chemotactic cytokines) are a large family of small, secreted proteins that signal through cell surface G‐protein coupled heptahelical chemokine receptors.
Braun A +11 more
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Teleost Chemokines and Their Receptors [PDF]
Biology, 2015 Chemokines are a superfamily of cytokines that appeared about 650 million years ago, at the emergence of vertebrates, and are responsible for regulating cell migration under both inflammatory and physiological conditions. The first teleost chemokine gene was reported in rainbow trout in 1998. Since then, numerous chemokine genes have been identified in
Bird, S., Tafalla, Carolina
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Chemokines and chemokine receptors in arthritis [PDF]
Frontiers in Bioscience, 2010 Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines.
Zoltán Szekanecz +4 more
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Questions about Chemokine and Chemokine Receptor Antagonism in Renal Inflammation [PDF]
, 2010 Chemokines remain attractive therapeutic targets for modulating inflammatory diseases in all areas of medicine including acute and chronic kidney disease.
Anders, Hans-Joachim +2 more
core +1 more source
CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer
Frontiers in Molecular Biosciences, 2020 In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya +4 more
doaj +1 more source
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]
, 2007 CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T. +7 more
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Chemokines and chemokine receptors: an overview
Frontiers in Bioscience, 2009 Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi +5 more
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Inhibition of chemokine-glycosaminoglycan interactions in donor tissue reduces mouse allograft vasculopathy and transplant rejection. [PDF]
PLoS ONE, 2010 Binding of chemokines to glycosaminoglycans (GAGs) is classically described as initiating inflammatory cell migration and creating tissue chemokine gradients that direct local leukocyte chemotaxis into damaged or transplanted tissues.
Erbin Dai +14 more
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The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis [PDF]
, 2018 Chemokines have been shown to be essential players in a range of cancer contexts. In this study, we demonstrate that mice deficient in the atypical chemokine receptor Ackr2 display impaired development of metastasis in vivo in both cell line and ...
Brownlie, Demi +12 more
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Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy
Frontiers in Immunology, 2019 Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Valeria Mollica Poeta +6 more
doaj +1 more source