Results 21 to 30 of about 240,302 (314)
CXC Chemokine/Receptor Axis Profile and Metastasis in Prostate Cancer
Frontiers in Molecular Biosciences, 2020 In this study, the effects of the CXC chemokine/receptor axis on lymph node and distant metastases of prostate cancer (PC) were analyzed. Further, mRNA expression data of metastatic PC were extracted from the Stand Up To Cancer–Prostate Cancer Foundation
Naoya Nagaya +4 more
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Chemokines and Chemokine Receptors: New Targets for Cancer Immunotherapy
Frontiers in Immunology, 2019 Immunotherapy is a clinically validated treatment for many cancers to boost the immune system against tumor growth and dissemination. Several strategies are used to harness immune cells: monoclonal antibodies against tumor antigens, immune checkpoint ...
Valeria Mollica Poeta +6 more
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Tumor Biology, 2017 C-X-C chemokine receptor 4 and Notch1 have been shown to play oncogenic role individually. This study aimed to determine the combinatorial role of C-X-C chemokine receptor 4 and Notch1 in lung adenocarcinoma.
Zhuangzhuang Cong +7 more
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Memorias do Instituto Oswaldo Cruz, 2013 American cutaneous leishmaniasis (ACL) presents distinct active clinical forms with different grades of severity, known as localised (LCL), intermediate (ICL) and diffuse (DCL) cutaneous leishmaniasis. LCL and DCL are associated with a polarised T-helper
Nilka Luisa Diaz +2 more
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Ligand-competent fractalkine receptor is expressed on exosomes
Biochemistry and Biophysics Reports, 2021 Expression of chemokine receptor CX3CR1 is reportedly restricted to several cell types including natural killer cells, cytotoxic T cells, monocytes, and macrophages.
Eun Jeong Park +9 more
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Viral Chemokine Receptors [PDF]
Frontiers in Immunology, 2015 When my lab sequenced the first chemokine receptors CXCR2 and CCR1 in 1991, the top BLAST hit for CCR1 was open reading frame (ORF) US28 of human cytomegalovirus (HCMV), indicating an obvious common ancestor and a possible example of gene piracy. Pox virologists had already identified virally encoded TNF and IFN-γ binding proteins, copied from the host
openaire +3 more sources
Multifaceted Roles of Chemokine C-X-C Motif Ligand 7 in Inflammatory Diseases and Cancer
Frontiers in Pharmacology, 2022 Over recent years, C-X-C motif ligand 7 (CXCL7) has received widespread attention as a chemokine involved in inflammatory responses. Abnormal production of the chemokine CXCL7 has been identified in different inflammatory diseases; nevertheless, the ...
Qianmiao Wu +3 more
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Chemokines and chemokine receptors: an overview
Frontiers in Bioscience, 2009 Chemokines are chemotactic cytokines orchestrating leukocyte recruitment in physiological and pathological conditions. This complex system includes 42 molecules and 19 receptors and is subjected to different levels of regulation, including ligand production, post-translational modifications and degradation, as well as receptor expression and signaling ...
R. Bonecchi +5 more
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CC chemokines and receptors in osteoarthritis: new insights and potential targets
Arthritis Research & Therapy, 2023 Osteoarthritis (OA) is a prevalent degenerative disease accompanied by the activation of innate and adaptive immune systems-associated inflammatory responses.
Yuchen Zhang +5 more
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PLoS ONE, 2014 Successful curative treatment of severe pulmonary arterial hypertension with luminal obliteration will require a thorough understanding of the mechanism underlying the development and progression of pulmonary vascular lesions.
Daniela Farkas +8 more
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