Results 31 to 40 of about 240,302 (314)

Shifting CCR7 towards Its Monomeric Form Augments CCL19 Binding and Uptake

Cells, 2022
The chemokine receptor CCR7, together with its ligands, is responsible for the migration and positioning of adaptive immune cells, and hence critical for launching adaptive immune responses. CCR7 is also induced on certain cancer cells and contributes to
Oliver J. Gerken, Marc Artinger, Daniel F. Legler   +2 more
doaj   +1 more source

Role of CXCR4 and SDF1 as prognostic factors for survival and the association with clinicopathology in colorectal cancer: A systematic meta-analysis

Tumor Biology, 2017
C-X-C chemokine receptor type 4 and stromal cell–derived factor-1 were proven to play important roles in several types of cancer and in many biological processes connected with tumor growth, invasion, angiogenesis, and metastasis.
Yao-ping Li, Jing Pang, Sheng Gao, Peng-yu Bai, Wen-da Wang, Pengzhou Kong, Yongping Cui   +6 more
doaj   +1 more source

Bidirectional Regulation of Opioid and Chemokine Function

Frontiers in Immunology, 2020
The opioid family of GPCRs consists of the classical opioid receptors, designated μ-, κ-, and δ-opioid receptors, and the orphanin-FQ receptor, and these proteins are expressed on both neuronal and hematopoietic cells.
Thomas J. Rogers
doaj   +1 more source

Atypical chemokine receptors

Experimental Cell Research, 2011
Atypical chemokine receptors (ACRs) are cell surface receptors with seven transmembrane domains structurally homologous to chemokine G-protein coupled receptors (GPCRs). However, upon ligation by cognate chemokines, ACRs fail to induce classical signaling and downstream cellular responses characteristic for GPCRs.
Ulvmar, Maria Helena, Hub, Elin, Rot, Antal   +2 more
openaire   +2 more sources

Chemokines and chemokine receptors in arthritis [PDF]

Frontiers in Bioscience, 2010
Chemokines are involved in leukocyte recruitment to inflammatory sites, such as the synovial tissue in rheumatoid arthritis (RA). There is a structural and a functional classification of chemokines. The former includes four groups: CXC, CC, C and CX3C chemokines.
Zoltan, Szekanecz, Aniko, Vegvari, Zoltan, Szabo, Alisa E, Koch   +3 more
openaire   +2 more sources

Spatio-temporal regulation of concurrent developmental processes by generic signaling downstream of chemokine receptors

eLife, 2018
Chemokines are secreted proteins that regulate a range of processes in eukaryotic organisms. Interestingly, different chemokine receptors control distinct biological processes, and the same receptor can direct different cellular responses, but the basis ...
Divyanshu Malhotra, Jimann Shin, Lilianna Solnica-Krezel, Erez Raz   +3 more
doaj   +1 more source

Chemokines, chemokine receptors, and cancer metastasis [PDF]

Journal of Leukocyte Biology, 2006
Abstract It is clear from large clinical studies that selected chemokine receptors are often up-regulated in a large number of common human cancers, including those of the breast, lung, prostate, colon, and melanoma. Chemokine receptors and their corresponding chemokine ligands have been demonstrated to play a number of nonredundant ...
Takashi, Kakinuma, Sam T, Hwang
openaire   +2 more sources

Mechanisms of chemokine recognition and receptor activation of chemokine receptor CCR7

Cell Reports
Summary: The chemokine receptor C-C chemokine receptor (CCR7) is essential for immune cell trafficking, cancer metastasis, and autoimmune diseases, making it a significant therapeutic target.
Yinglong Cao, Chao Zhang, Qingning Yuan, Fenghui Zhao, Qiufeng Liu, Kai Wu, Wen Hu, Jin He, Hongchun Li, H. Eric Xu, Dehua Yang, Jia Duan   +11 more
doaj   +1 more source

Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses [PDF]

Biotechnologie, Agronomie, Société et Environnement, 2007
The chemokines and their receptors: the main functions of chemokines are cell activation and stimulation of leukocyte migration. By interacting with G protein-coupled receptors, these proteins regulate many biological processes like apoptosis ...
Catherine Burteau, Richard Kettmann, Luc Willems   +2 more
doaj  

Chemokines, Chemokine Receptors, and Allograft Rejection [PDF]

Immunity, 2001
Chemokines are pivotal mediators in allograft rejection by virtue of their activity as regulators of leukocyte movement, adhesion, and effector function. Because the regulation of effector cell infiltration is complex, it is difficult to dissect the relative role of each chemokine in the inflammatory processes leading to allograft rejection, especially
Nelson, Peter J., Krensky, Alan M.
openaire   +2 more sources