A mechanically active OsteoChondral Unit (OCU)‐on‐Chip platform mimicking the OCU's functional anatomy and the strain gradient across the osteochondral interface is presented. Upon compartment‐specific hyperphysiological compression, the model replicates mechanisms observed in osteoarthritis (OA) progression, such as calcium crystal accumulation ...
Andrea Mainardi+10 more
wiley +1 more source
Granular hydrogels are emerging microporous platforms for cell culture and delivery, showing great potential for replicating the complex, heterogeneous environments found in natural tissues. This review outlines the design principles of granular hydrogels, highlighting critical factors that determine the final physicochemical properties of the entire ...
Shuhan Feng, Kaiyang Chen, Shiqi Wang
wiley +1 more source
CTACK, a skin-associated chemokine that preferentially attracts skin-homing memory T cells
Janine Morales+10 more
openalex +1 more source
Regulation of cytokine expression and leukotriene formation in human basophils by growth factors, chemokines and chemotactic agonists [PDF]
B Ochensberger+4 more
openalex +1 more source
This work presents a “tooth‐on‐chip” device that mimics dental pulp tissue. By co‐culturing key cell types, it recreates vascular networks, stem cell niches, the odontoblast/dentine interface, and trigeminal innervation. This innovative platform provides a unique model of dental pulp structure and physiology, with significant potential for accelerating
Alessandro Cordiale+6 more
wiley +1 more source
Chemokines: humble yet mighty players in the tumour microenvironment. [PDF]
Xavier H+8 more
europepmc +1 more source
Kinetics of Transcription Factors Regulating the RANTES Chemokine Gene Reveal a Developmental Switch in Nuclear Events During T-Lymphocyte Maturation [PDF]
Benjamin Ortiz+2 more
openalex +1 more source
Advanced Nanoparticle Therapeutics for Targeting Neutrophils in Inflammatory Diseases
This review highlights recent advances in nanoparticle‐based strategies to modulate neutrophil activity in inflammatory diseases. By targeting inflammatory neutrophils, NET formation, and neutrophil apoptosis or recruitment, these approaches aim to improve therapeutic precision.
Min Ji Byun+9 more
wiley +1 more source
A Comprehensive Assessment of Plasma CXCL9 and CXCL10 in Improving Clinical Prediction Models for Kidney Allograft Rejection. [PDF]
Souza AA+7 more
europepmc +1 more source
The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation [PDF]
Dolores M. Conroy+7 more
openalex +1 more source