Results 11 to 20 of about 31,865 (216)
Chemoprevention of cancer [PDF]
Carcinogenesis, 2000 In this short article, we review the conceptual basis for chemoprevention of cancer, the proven clinical efficacy of this concept, and current trends to develop new chemopreventive agents based on understanding of their mechanisms of action. Four classes of new agents, namely selective inhibitors of cyclooxygenase-2, selective estrogen receptor ...
Michael B. Sporn, Nanjoo Suh
openalex +4 more sources
Cancer, 1993 Encouraging results from several recent trials have increased interest in the potential of chemoprevention in reducing the incidence of cancer. Treatment with 13-cis-retinoic acid has reversed oral leukoplakia, a premalignant lesion, and prevented the development of second primary carcinomas of the head and neck.
Loretta M. Itri
openalex +3 more sources
Chemoprevention research in Europe [PDF]
International Journal of Cancer, 1997 The basis for primary prevention of cancer is well-established, because significant causes of cancer are known. However, apart from reducing cigarette smoking, few easily applicable measures to decrease cancer incidence are available. Recently, there has been much interest in chemoprevention in cancer control, with several international bodies ...
Matti Hakama
openalex +4 more sources
CA: A Cancer Journal for Clinicians, 1995 Chemoprevention has been shown to be an extremely promising approach to the prevention of invasive cancer. Through the identification of chemopreventive agents that inhibit or reverse the process of carcinogenesis, new strategies of early intervention can be developed for patients at high risk that potentially prevent the onset of invasive and ...
Mph Barnett S. Kramer Md +3 more
openaire +3 more sources
Journal of Biomedicine and Biotechnology, 2012 Cancers are characterized by the dysregulation of cell signaling pathways at multiple steps. Most current anticancer therapies however involve the modulation of a single target. The lack of safety and high cost of monotargeted therapies have encouraged alternative approaches.
Amin, Amr +3 more
openaire +2 more sources
Chemoprevention of Cancer [PDF]
CA: A Cancer Journal for Clinicians, 2004 Cancer chemoprevention is defined as the use of natural, synthetic, or biologic chemical agents to reverse, suppress, or prevent carcinogenic progression to invasive cancer. The success of several recent clinical trials in preventing cancer in high-risk populations suggests that chemoprevention is a rational and appealing strategy.
Waun Ki Hong +2 more
openaire +3 more sources
NSAIDs and Chemoprevention [PDF]
Current Cancer Drug Targets, 2004 Several epidemiological, clinical and experimental studies established nonsteroidal anti-inflammatory drugs (NSAIDs) as promising cancer chemopreventive agents. Long-term use of aspirin and other NSAIDs has been shown to reduce the risk of cancer of the colon and other gastrointestinal organs as well as of cancer of the breast, prostate, lung, and skin.
Bandaru S. Reddy, Chinthalapally V. Rao
openaire +3 more sources
Oncotarget, 2014 Cancer chemoprevention employs natural, synthetic, or biologic substances to reverse, suppress, or prevent the development of cancer. Initially these agents were developed to reduce cancer risk or retard its development, but were not intended to treat cancer. Celecoxib, a selective cyclooxygenase-2 (COX-2) inhibitor, is used clinically to prevent polyp
Brad St. Croix +2 more
openaire +3 more sources
Chemoprevention: Will it work? [PDF]
International Journal of Cancer, 1997 Cancer chemoprevention has been a major area of inquiry in the United States for over a decade. The field originated from the confluence of developments in laboratory carcinogenesis and nutritional epidemiology. Although still owing much to other research disciplines, chemoprevention researchers have developed models and methodologies specific to the ...
openaire +3 more sources
ISCC (Indonesian Journal of Cancer Chemoprevention), 2011 The chemopreventive effect of Ficus septica Burm. f. leaves ethanolic extract (FLEE) was studied in 7,12-dimethylbenz[a]nthracene(DMBA)-induced rat liver cancer. Rats were divided into 5 group, 5 rats (5 wk of age Sprague Dawley rat) in each group. Group
Dita Brenna Septhea +5 more
doaj +1 more source