Results 111 to 120 of about 64,721 (205)

Body mass index as a predictive factor for efficacy of adjuvant taxane‐based chemotherapy in early‐stage breast cancer patients: A pooled analysis from adjuvant GEICAM Spanish Breast Cancer Group and TRIO Translational Research in Oncology Group studies

International Journal of Cancer, EarlyView.
What's New? Body mass index (BMI) potentially influences outcomes among women with early‐stage breast cancer (EBC). Little is known, however, about relationships between BMI and disease prognosis for different adjuvant taxane‐based chemotherapies. Here, the prognostic effect of BMI on disease recurrence was evaluated among EBC patients treated with ...
José A. García‐Saenz, Gonzalo Spera, Marina Pollán, Begoña Bermejo, Manuel Ruiz‐Borrego, Arlene Chan, Miguel Martín, Ángel Guerrero‐Zotano, Lourdes Calvo, Álvaro Rodríguez‐Lescure, María Marín, Linnea Chap, John Crown, Tadeusz Pienkowski, Valerie Bee, Maribel Casas, Óscar Polonio, Susana Bezares, Dennis Slamon   +18 more
wiley   +1 more source

Patient‐derived tumor organoids highlight the potential of precision medicine in managing pancreatic ductal adenocarcinoma

International Journal of Cancer, EarlyView.
What's New? Only about one‐fifth of patients with pancreatic ductal adenocarcinoma (PDAC) qualify for curative treatment approaches employing adjuvant chemotherapy. Tools to predict PDAC response to chemotherapeutic regimens, however, are lacking.
Christine Nitschke, Charline Phan, Yara Souto, Philipp Walter, Mara Goetz, Gediminas Simkus, Jacob Thastrup, Ronald Simon, Jürgen Kupper, Jakob Izbicki, Steven A. Johnsen, Thilo Hackert, Marianne Sinn, Harriet Wikman, Faik G. Uzunoglu, Tabea M. Sturmheit   +15 more
wiley   +1 more source

Artificial intelligence in the diagnosis and management of gynecologic cancer

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Gynecologic cancers affect over 1.2 million women globally each year. Early diagnosis and effective treatment are essential for improving patient outcomes, yet traditional diagnostic methods often encounter limitations, particularly in low‐resource settings.
Chaiyawut Paiboonborirak, Nadeem R. Abu‐Rustum, Sarikapan Wilailak   +2 more
wiley   +1 more source

HOXC11-mediated regulation of mitochondrial function modulates chemoresistance in colorectal cancer

BMC Cancer
Background Chemoresistance remains a significant challenge in colorectal cancer (CRC) treatment, necessitating a deeper understanding of its underlying mechanisms.
Shicheng Chu, Xiang Ren, Lianmeng Cao, Chong Ma, Kai Wang   +4 more
doaj   +1 more source

Environment, lifestyle, and cancer in women

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Environmental and lifestyle factors significantly contribute to gynecological cancers. The risk of ovarian cancer, one the most lethal gynecological cancer, is associated with obesity, poor dietary habits, and environmental pollutants, exacerbating hormonal imbalances, inflammation, and oxidative stress.
Sara Farina, Alessandra Sabatelli, Stefania Boccia, Giovanni Scambia   +3 more
wiley   +1 more source

HTRA1 interacts with SLC7A11 to modulate colorectal cancer chemosensitivity by inhibiting ferroptosis

Cell Death Discovery
Chemotherapy is an important therapuetic strategy for colorectal cancer (CRC), but chemoresistance severely affects its efficacy, and the underlying mechanism has not been fully elucidated.
Weiwei Liu, Chaoqun Liu, Jun Xiao, Cheng Qian, Zhilin Chen, Wandie Lin, Yujie Zhang, Jianghua Wu, Rui Zhou, Liang Zhao   +9 more
doaj   +1 more source

Chitosan‐Based Nanoparticles for Twist1 Knockdown in 4T1 Cells

Macromolecular Bioscience, EarlyView.
Modified chitosan nanoparticles have the potential for passive and active siRNA delivery to different tumors. This study evaluates twist1‐siRNA‐loaded pegylated chitosan and alendronate‐conjugated pegylated chitosan nanoparticles for twist1 gene silencing in 4T1 cells.
Asim Mushtaq, Li Li, Anitha A, Lisbeth Grøndahl   +3 more
wiley   +1 more source

SOAT1 Activates NLRP3 Inflammasome to Promote Cancer‐Related Lymphangiogenesis and Metastasis via IL‐1β/IL‐1R‐1 Axis in Oral Squamous Cell Carcinoma

Molecular Carcinogenesis, EarlyView.
ABSTRACT Oral squamous cell carcinoma (OSCC) is a prevalent type of cancer in the head and neck region, significantly impacting patient survival rates and quality of life. Lymph node (LN) metastasis is a lead contributor to the poor prognosis associated with OSCC.
Chengzhi Zhao, Yuhao Wang, Zhishen Jiang, Shengzhao Guo, Liru Hu, Jian Pan, Fan Dan   +6 more
wiley   +1 more source

Effect of Natural Polyphenols on Breast Cancer Chemoprevention and Treatment

Molecular Nutrition &Food Research, EarlyView.
Effect of Natural Polyphenols on Breast Cancer proliferation and progression. ABSTRACT Breast cancer is the most common type of malignancy among women worldwide. Significant achievements have been made in diagnostic tools and cancer treatments in the past decade; however, the complexity and heterogeneity of certain breast cancer subtypes often lead to ...
Marzia Sichetti, Martina Giuseffi, Eugenia Giglio, Graziella Marino, Marisabel Mecca   +4 more
wiley   +1 more source

A breast cancer PDX collection enriched in luminal (ER+) tumors and young premenopausal patients to identify new therapeutic strategies for high‐risk patients†

The Journal of Pathology, EarlyView.
Abstract Breast cancer includes a group of neoplasms originating from mammary gland epithelial cells caused by a variety of genetic alterations, with different responses to treatments and outcomes. In clinical practice, estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) expression guides the ...
Paola Defilippi, Francesca Nigrelli, Pietro Arina, Daniela Taverna, Vincenzo Salemme   +4 more
wiley   +1 more source