Results 291 to 300 of about 133,761 (337)

ARID3A Dysregulation Drives Colon Cancer Progression and Enhances Responsiveness to Aspirin

Journal of Cellular and Molecular Medicine, Volume 30, Issue 3, February 2026.
ABSTRACT The AT‐Rich Interaction Domain (ARID) family plays critical roles in malignancies. Although numerous members have been shown to influence cancer processes, there is a lack of a general understanding of the ARID family in colon cancer. To address this gap, we used bioinformatic technologies to investigate the role of the ARID family as a whole ...
Jiade Li, Muhan Li, Quanfu Li, Yungaowa Wu, Yifan Shen, Yanping Li, Mingshuo Zhang, Guangyou Wang, Yuanyuan Zhu   +8 more
wiley   +1 more source

Osimertinib inhibits the MYLK4-mediated phosphorylation of CDKAL1 to suppress stemness and chemoresistance in rhabdomyosarcoma. [PDF]

Signal Transduct Target Ther
Itano T, Huang R, Ozaki T, Nakata E, Fujimura A.   +4 more
europepmc   +1 more source

Unlocking the Therapeutic Potential of Integrin‐Linked Kinase Inhibitors in Bioengineered 3D Breast Tumor Stroma Models

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
3D cancer models provide a more reliable representation of drug responses compared to 2D cell culture owing to their 3D architecture and facilitation of cell‐extracellular matrix interactions. In this study, we engineered dense compartmentalized 3D tumoroids composed of breast tumor mass and a surrounding stromal compartment replicating either breast ...
Salma T. Rafik, Anuja Upadhyay, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

The immunotherapy era in ovarian clear cell carcinoma: current evidence and future perspective. [PDF]

Front Immunol
Passarelli A, Cecere SC, Ventriglia J, Pisano C, De Cecio R, Rossetti S, Tambaro R, Di Napoli M, Lobianco L, Calvanese G, Lamia MR, Perri E, Peluso MS, Scarpa E, Stilo S, Fiore F, Setola SV, Califano D, Pignata S.   +18 more
europepmc   +1 more source

The role of fibroblast growth factors in cell and cancer metabolism

FEBS Letters, Volume 600, Issue 2, Page 140-163, January 2026.
Fibroblast growth factor (FGF) signaling regulates crucial signaling cascades that promote cell proliferation, survival, and metabolism. Therefore, FGFs and their receptors are often dysregulated in human diseases, including cancer, to sustain proliferation and rewire metabolism.
Jessica Price, Chiara Francavilla
wiley   +1 more source

<i>Fusobacterium nucleatum</i> and Its Impact on Colorectal Cancer Chemoresistance: A Meta-Analysis of In Vitro Co-Culture Infections. [PDF]

Cancers (Basel)
Risoen KR, Shaw CA, Chien J, Weimer BC.
europepmc   +1 more source

Systemic and local decorin levels mirror the clinical course of pancreatic cancer

The Journal of Pathology: Clinical Research, Volume 12, Issue 1, January 2026.
Abstract Despite significant progress in oncology research, pancreatic cancer remains inherently difficult to treat, and the mechanisms underlying therapeutic resistance remain unresolved. Decorin (DCN), a member of the family of small leucine‐rich proteoglycans, has emerged as a versatile actor in various malignant diseases.
Maja Svensson, Sophie Lehn, Hedda Jacobsen, Sofie Olsson Hau, Göran Jönsson, Kristian Pietras, Karin Jirström   +6 more
wiley   +1 more source

Inhibition of CRM1 reverses hypoxia-driven chemoresistance in acute myeloid leukemia via overcoming HIF-1α-mediated lysosomal sequestration. [PDF]

Front Immunol
Feng X, Ding Y, Huang Y, Qin H, Wang X, Zeng Y.   +5 more
europepmc   +1 more source

Supplementary Table S5 from Single-Cell Evolutionary Analysis Reveals Drivers of Plasticity and Mediators of Chemoresistance in Small Cell Lung Cancer

Hannah Wollenzien, Yohannes Afeworki Tecleab, Robert Szczepaniak‐Sloane, Anthony Restaino, Michael S. Kareta   +4 more
openalex   +1 more source

Chemoresistance in gonorrhea.

Acta dermato-venereologica, 2010
openaire   +1 more source