Results 81 to 90 of about 149,400 (379)
Hypoxia, endoplasmic reticulum stress and chemoresistance: dangerous liaisons
Journal of experimental & clinical cancer research : CR, 2021 Solid tumors often grow in a micro-environment characterized by
M. Akman +6 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane +16 more
wiley +1 more source
Tumor chemosensitivity and chemoresistance assays [PDF]
Cancer, 1996 Chemosensitivity and chemoresistance assays have been used to select potentially more effective chemotherapy regimens and to avoid the toxicity of potentially ineffective drugs.Literature review was conducted.The relevant outcome measure for chemosensitivity assays is improved patient survival.
Maurie Markman, Elizabeth Brown
openaire +3 more sources
Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers. [PDF]
, 2020 Tumor-associated p53 mutations endow cells with malignant phenotypes, including chemoresistance. Amyloid-like oligomers of mutant p53 transform this tumor suppressor into an oncogene.
de Oliveira, Guilherme AP +8 more
core +1 more source
Emerging role of nuclear factor erythroid 2-related factor 2 in the mechanism of action and resistance to anticancer therapies [PDF]
, 2019 Nuclear factor E2-related factor 2 (NRF2), a transcription factor, is a master regulator of an array of genes related to oxidative and electrophilic stress that promote and maintain redox homeostasis. NRF2 function is well studied in in vitro, animal and
Deeni, Yusuf Y. +3 more
core +2 more sources
MiRNAs as novel adipokines : obesity-related circulating MiRNAs influence chemosensitivity in cancer patients [PDF]
, 2020 Adipose tissue is an endocrine organ, capable of regulating distant physiological processes in other tissues via the release of adipokines into the bloodstream.
Dewhurst, T +3 more
core +2 more sources
Molecular Oncology, EarlyView.Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley +1 more source
OverAKT3: tumor progression and chemoresistance [PDF]
Cell Cycle, 2015 Akt3 is one of 3 closely related serine/threonine-protein kinases in the Akt family (Akt1, Akt2, and Akt3). Akt is among the most hyperactivated oncogenes in human cancer, regulating key cellular functions such as growth, proliferation, migration, invasion, angiogenesis, metabolism, and survival.1,2 Studies evaluating the effect of Akt isoform gene ...
Wei Zhang, Ping Ji, Kristen M. Turner
openaire +3 more sources
Antioxidant and Anticancer Activity of Vitis vinifera Extracts in Breast Cell Lines
LifeVitis vinifera extracts have been shown to possess antioxidant activity because of their polyphenol content. In addition, their therapeutic potential against several diseases, including cancer, has been reported.
Evgenia Maria Tsantila +4 more
doaj +1 more source
Notch3 targeting. A novel weapon against ovarian cancer stem cells [PDF]
, 2019 Notch signaling is frequently activated in ovarian cancer (OC) and contributes to the proliferation and survival of cultured OC cells as well as to tumor formation and angiogenesis in xenograft models.
Bellavia, Diana +5 more
core +1 more source