Results 81 to 90 of about 64,721 (205)

CYP19A1 regulates chemoresistance in colorectal cancer through modulation of estrogen biosynthesis and mitochondrial function

Cancer & Metabolism
Chemoresistance remains a major challenge in the effective treatment of colorectal cancer (CRC), contributing to poor patient outcomes. While the molecular mechanisms underlying chemoresistance are complex and multifaceted, emerging evidence suggests ...
Yang Wang, Qiang Ji, Ning Cao, Guijie Ge, Xiaomin Li, Xiangdong Liu, Yanqi Mi   +6 more
doaj   +1 more source

Evolutionary dynamics in vascularised tumours under chemotherapy [PDF]

arXiv, 2019
We consider a mathematical model for the evolutionary dynamics of tumour cells in vascularised tumours under chemotherapy. The model comprises a system of coupled partial integro-differential equations for the phenotypic distribution of tumour cells, the concentration of oxygen and the concentration of a chemotherapeutic agent.
arxiv  

Targeted Penetrating Motif Engineering of BH3 Mimetic: Harnessing Non‐Canonical Amino Acids for Coinhibition of MCL‐1 and BCL‐xL in Acute Myeloid Leukemia

Advanced Science, EarlyView.
A structure‐guided peptide derived from a non‐canonical amino acid library simultaneously targets MCL‐1 and BCL‐xL to overcome apoptotic resistance in acute myeloid leukemia. Fused with a CXCR4‐binding motif, the engineered peptide exhibits selective intracellular delivery and potent in vivo efficacy, offering a promising therapeutic strategy against ...
Zhe Wang, Ruizhi Lai, Xinpei Wang, Xu Chen, Youjian Zhou, Shengbin Li, Xiaohui Qiu, Zekai Zeng, Jianye Yuan, Jinghuan Mao, Zhidong Chen, Junqing Wang   +11 more
wiley   +1 more source

DNA methylation characteristics associated with chemotherapy resistance in epithelial ovarian cancer

Heliyon
Objective: The high mortality rate of epithelial ovarian cancer (EOC) is often attributed to the frequent development of chemoresistance. DNA methylation is a predictive biomarker for chemoresistance. Methods: This study utilized DNA methylation profiles
Changling Duan, Zhongxin Yan, Cailiang Wu, Xuexin Zhou, Wei Bao   +4 more
doaj  

Comprehensive genetic analysis of poorly differentiated gastric cancer in young females

Annals of Gastroenterological Surgery, EarlyView.
Although the involvement of female sex hormones in the development of poorly differentiated gastric cancer in young females is controversial, our detailed analysis using RNA‐seq suggested that the female sex hormone, β‐estradiol plays a role in the development of poorly differentiated gastric cancer in young females. Abstract Aim The reasons behind the
Nobuhiro Nakazawa, Takehiko Yokobori, Yohei Morishita, Akinobu Echigo, Reika Kawabata‐Iwakawa, Akiharu Kimura, Akihiko Sano, Makoto Sakai, Ken Shirabe, Hiroshi Saeki   +9 more
wiley   +1 more source

TP53‐Mutated Myeloid Neoplasms: 2024 Update on Diagnosis, Risk‐Stratification, and Management

American Journal of Hematology, EarlyView.
ABSTRACT Alterations in the tumor suppressor gene TP53 are common in human cancers and are associated with an aggressive nature. Approximately 8%–12% of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) harbor TP53 mutations (TP53mut) and present immense challenges due to inherent chemoresistance and poor outcomes.
Mithun Vinod Shah, Daniel A. Arber, Devendra K. Hiwase   +2 more
wiley   +1 more source

Mitophagy: A novel perspective for insighting into cancer and cancer treatment

Cell Proliferation, Volume 55, Issue 12, December 2022., 2022
Mitophagy is a physiological process regulated by complex and diverse mechanisms. Here we summarize the 15 main molecular mechanisms involved in the mammalian mitophagy processes and some potential anticancer drugs targeting mitophagy. Abstract Background Mitophagy refers to the selective self‐elimination of mitochondria under damaged or certain ...
Congkuan Song, Shize Pan, Jinjin Zhang, Ning Li, Qing Geng   +4 more
wiley   +1 more source

miR-374a-5p: A New Target for Diagnosis and Drug Resistance Therapy in Gastric Cancer

Molecular Therapy: Nucleic Acids, 2019
Chemoresistance is one of the causes associated with poor prognosis in gastric cancer. MicroRNAs (miRNAs) are important regulators of chemoresistance. Exosome-mediated delivery of anti-cancer molecules and drugs have emerged as a new approach for cancer ...
Runbi Ji, Xu Zhang, Hongbing Gu, Jichun Ma, Xiangmei Wen, Jingdong Zhou, Hui Qian, Wenrong Xu, Jun Qian, Jiang Lin   +9 more
doaj  

Mechanisms Underlying Chemoresistance of Choriocarcinoma Investigated with NMR-Based Metabonomics

Chinese Journal of Magnetic Resonance, 2019
Choriocarcinoma (CC) is a malignant trophoblastic tumor that occurs in women of childbearing age. Its cure rate could be over 90% following single drug or multidrug chemotherapy with methotrexate, 5-fluorouracil and etc. Chemoresistance is the main cause
DING Lai-feng, ZHANG Cong-cong, HU Qing-yu, Olivier E. PARDO, Michael J. SECKL, WANG Yu-lan, WU Jun-fang   +6 more
doaj   +1 more source

Bioactives From Brown Algae: Antioxidant, Anti‐Inflammatory, Anticancer, and Antimicrobial Potential

ChemBioEng Reviews, EarlyView.
This review explores key bioactives in brown algae and their antioxidant, anti‐inflammatory, anticancer, and antimicrobial properties. Covering studies from 2014 to 2024, it highlights their relevance in pharmaceuticals, nutraceuticals, cosmetics, and foods, while addressing challenges and future directions to unlock their full potential.
Irvin Fonseca‐Barahona, Kaveh Shahbaz, Saeid Baroutian   +2 more
wiley   +1 more source