Results 81 to 90 of about 133,761 (337)

Estimation of Reserves for Improving the Results of Patients with Multipresistant Pulmonary Tuberculosis in the Application of Surgical Methods Based on Analysis of the Efficiency of Conservative Treatment of a Specified Cohort [PDF]

, 2018
In order to improve the results of treatment of patients with multi-resistant pulmonary tuberculosis with the use of surgical methods, the effectiveness estimation of conservative treatment of 176 patients with this form of tuberculosis according to ...
Ivashchenko, V. (Vladimir), Kalabukha, I. (Igor), Khmel, O. (Oleg)   +2 more
core   +2 more sources

Cancer chemoresistance and BAK

Oncoscience, 2015
Blocking or evading apoptosis is one of the hallmarks of cancer [1]. Recent advances in genomic sequencing have identified many mutations in cancer cells, prompting an increased effort to identify driver mutations in critical pathways that impact upon cell survival. Interestingly though, many cancers have intact apoptotic machinery where mutation rates
openaire   +2 more sources

Unraveling the Molecular Mechanisms of Glioma Recurrence: A Study Integrating Single‐Cell and Spatial Transcriptomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Glioma recurrence severely impacts patient prognosis, with current treatments showing limited efficacy. Traditional methods struggle to analyze recurrence mechanisms due to challenges in assessing tumor heterogeneity, spatial dynamics, and gene networks.
Lei Qiu, Yinjiao Fei, Jiaxuan Ding, Kexin Shi, Jinyan Luo, Yuchen Zhu, Xingjian Sun, Gefei Jiang, Yuandong Cao, Weilin Xu, Shu Zhou   +10 more
wiley   +1 more source

Exosome-transmitted LUCAT1 promotes stemness transformation and chemoresistance in bladder cancer by binding to IGF2BP2

Journal of Experimental & Clinical Cancer Research
The chemotherapy resistance is an awkward challenge in management of bladder cancer (BC). Cancer organoid model is an effective preclinical tumor model that could faithfully represent clinical manifestations and simulate the biological processes of ...
Yonghao Zhan, Zhenzhen Zhou, Zhaowei Zhu, Lianghao Zhang, Shuanbao Yu, Yuchen Liu, Xuepei Zhang   +6 more
doaj   +1 more source

MiR-193a regulates chemoresistance of human osteosarcoma cells via repression of IRS2

Journal of Bone Oncology, 2019
Chemoresistance prevents curative potential of chemotherapy in most cases. MicroRNAs (miRNAs) are key players in regulating chemoresistance in osteosarcoma, which is the most common primary bone cancer. Bisulfite sequencing and quantitative real time PCR
Haiyan Wang, Fangfang Zhao, Shanbao Cai, Youguang Pu   +3 more
doaj   +1 more source

The role of peroxiredoxins in cancer [PDF]

, 2017
Peroxiredoxins (PRDXs) are a ubiquitously expressed family of small (22-27 kDa) non-seleno peroxidases that catalyze the peroxide reduction of H2O2, organic hydroperoxides and peroxynitrite.
CAPALBO, CARLO, COPPA, Anna, D'INZEO, SONIA, GIANNINI, Giuseppe, NICOLUSSI, Arianna   +4 more
core   +1 more source

Decellularized Extracellular Matrix Scaffolds to Engineer the Dormant Landscape of Microscopic Colorectal Cancer Liver Metastasis

Advanced Healthcare Materials, EarlyView.
Decellularized liver extracellular matrix scaffolds provide a platform to study dormant liver‐metastatic colorectal cancer. They induce reversible dormancy, in combination with nutrient depletion and low dose chemotherapy, through cell cycle arrest and chemotherapy resistance.
Sabrina N. VandenHeuvel, Lucia L. Nash, Abigail J. Clevenger, Claudia A. Collier, Oscar R. Benavides, Sanjana Roy, Brinlee Goggans, Aelita Salikhova, Anvitha Tharakesh, Svasti Haricharan, Amber N. Stratman, Scott Kopetz, Alex J. Walsh, Shreya A. Raghavan   +13 more
wiley   +1 more source

Long noncoding RNA MALAT1 regulates autophagy associated chemoresistance via miR-23b-3p sequestration in gastric cancer

Molecular Cancer, 2017
Background Chemoresistance has long been recognized as a major obstacle in cancer therapy. Clarifying the underlying mechanism of chemoresistance would result in novel strategies to improve patient’s response to chemotherapeutics.
Hu YiRen, Yu YingCong, You Sunwu, Li Keqin, Tong Xiaochun, Chen Senrui, Chen Ende, Lin XiZhou, Chen Yanfan   +8 more
doaj   +1 more source

Doxorubicin‐Loaded Metal–Organic Framework for Ferroptosis‐Enhanced Chemotherapy Through Sustained Zn Release and Glutathione Peroxidase Downregulation

Advanced Healthcare Materials, EarlyView.
A robust zinc‐based metal–organic framework (ZnMOF) enables dual functions of doxorubicin delivery and sustained Zn2+ release to trigger ferroptosis‐enhnaced chemotherapy. DOX@ZnMOF effectively depletes intracellular glutathione, suppresses GPX4, and elevates reactive oxygen species, leading to efficient oxidative DNA damage and apoptosis.
Xin Ma, Chenghua Deng, Chaoyu Wang, Langston Tilman, Jinhong Li, Wenbin Lin   +5 more
wiley   +1 more source

DNA-methylation eraser TET2 activates WTIP expression to suppress an AKT-dependent chemoresistance of gastric cancer

Neoplasia: An International Journal for Oncology Research
Chemoresistance is one of the major causes of the failure in gastric cancer (GC) treatment and leads to poor clinical outcomes. Ten-eleven translocation (TET) 2 expression and activity are frequently reduced in solid tumors.
Yan Guo, Hongyang Yu, Jinyang Li, Kewei Liu, Mengyi Han, Yuxin Tang, Li Su, Xianfeng Li, Haixia Wu, Dongfeng Chen   +9 more
doaj   +1 more source