Results 1 to 10 of about 386,482 (254)

C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis

Frontiers in Immunology, 2022
Phagocytosis, macropinocytosis, and G protein coupled receptor-mediated chemotaxis are Ras-regulated and actin-driven processes. The common regulator for Ras activity in these three processes remains unknown.
Xuehua Xu, Henderikus Pots, Bernd K. Gilsbach, Dustin Parsons, Douwe M. Veltman, Sharmila G. Ramachandra, Haoran Li, Arjan Kortholt, Tian Jin   +8 more
doaj   +1 more source

Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range

Frontiers in Cell and Developmental Biology, 2021
Chemotaxis, which is G protein-coupled receptor (GPCR)-mediated directional cell migration, plays pivotal roles in diverse human diseases, including recruitment of leukocytes to inflammation sites and metastasis of cancer.
Xuehua Xu, Smit Bhimani, Henderikus Pots, Xi Wen, Taeck J. Jeon, Arjan Kortholt, Tian Jin   +6 more
doaj   +1 more source

Optimal decision making for sperm chemotaxis in the presence of noise [PDF]

, 2017
For navigation, microscopic agents such as biological cells rely on noisy sensory input. In cells performing chemotaxis, such noise arises from the stochastic binding of signaling molecules at low concentrations.
Baier, Christel, Friedrich, Benjamin M., Kromer, Justus A., Lange, Steffen, Märcker, Steffen   +4 more
core   +9 more sources

Evolution of Reproductive Division of Labor – Lessons Learned From the Social Amoeba Dictyostelium discoideum During Its Multicellular Development

Frontiers in Cell and Developmental Biology, 2021
The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that
Ranjani Dhakshinamoorthy, Shashi P. Singh   +1 more
doaj   +1 more source

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
A Boucharaba, AD Mackenzie Ross, AJ Houben, AJ Muinonen-Martin, AJ Snider, AL Parrill, AM Algra, Andre Levchenko, Andrew J. Muinonen-Martin, C Carmona-Fontaine, C Scherber, C Zhao, CK Griffith, CM Balch, Colin Lindsay, D Dankort, D Zicha, D Zicha, David A. Knecht, Dorothy C. Bennett, Douwe M. Veltman, E Dona, E Lee, E Sierko, E Theveneau, Elizabeth Smethurst, ET Roussos, F Wach, G Tigyi, G Valentin, G Venkiteswaran, Gabriela Kalna, GL Garcia, J Condeelis, J Condeelis, J Murata, J Sleeman, J Wyckoff, JD Pedelacq, JM Haugh, JP Sleeman, JT Price, K Bandoh, K Jalink, Laura M. Machesky, M Abercrombie, M Gotoh, M Herlyn, M Jongsma, M Zaki, Michael J. O. Wakelam, MJ Payette, N Aaltonen, Olivia Susanto, Owen J. Sansom, P Berens, P Timpson, PN Devreotes, Qifeng Zhang, RA Sturm, Robert H. Insall, Robert Herd, Robert Jones, RR Langley, S Kuriyama, S Toetsch, S Toyozawa, SA Jordan, SH Zigmond, SH Zigmond, SK Hughes-Alford, W Wang, William J. Faller   +72 more
core   +12 more sources

Multiple CheY Proteins Control Surface-Associated Lifestyles of Azospirillum brasilense

Frontiers in Microbiology, 2021
Bacterial chemotaxis is the directed movement of motile bacteria in gradients of chemoeffectors. This behavior is mediated by dedicated signal transduction pathways that couple environment sensing with changes in the direction of rotation of flagellar ...
Elena E. Ganusova, Lam T. Vo, Tanmoy Mukherjee, Gladys Alexandre   +3 more
doaj   +1 more source

Derivatives of Differentiation-Inducing Factor 1 Differentially Control Chemotaxis and Stalk Cell Differentiation in Dictyostelium discoideum

Biology, 2023
Differentiation-inducing factors 1 and 2 (DIF-1 and DIF-2) are small lipophilic signal molecules that induce stalk cell differentiation but differentially modulate chemotaxis toward cAMP in the cellular slime mold Dictyostelium discoideum; DIF-1 ...
Hidekazu Kuwayama, Haruhisa Kikuchi, Yuzuru Kubohara   +2 more
doaj   +1 more source

Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors

Journal of Neuroinflammation, 2022
Background Listeria monocytogenes (Lm) is a bacterial pathogen of major concern for humans and ruminants due to its neuroinvasive potential and its ability to cause deadly encephalitis (neurolisteriosis).
Stefano Bagatella, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt, Anna Oevermann   +9 more
doaj   +1 more source

Cells collectively migrate during ammonium chemotaxis in Chlamydomonas reinhardtii

Scientific Reports, 2023
The mechanisms governing chemotaxis in Chlamydomonas reinhardtii are largely unknown compared to those regulating phototaxis despite equal importance on the migratory response in the ciliated microalga.
Gabela Nelson, Alexis Strain, Atsuko Isu, Alireza Rahnama, Ken-ichi Wakabayashi, Adam T. Melvin, Naohiro Kato   +6 more
doaj   +1 more source

Subversion of Phytomyxae Cell Communication With Surrounding Environment to Control Soilborne Diseases; A Case Study of Cytosolic Ca2+ Signal Disruption in Zoospores of Spongospora subterranea

Frontiers in Microbiology, 2022
Ca2+ signaling regulates physiological processes including chemotaxis in eukaryotes and prokaryotes. Its inhibition has formed the basis for control of human disease but remains largely unexplored for plant disease.
Jonathan Amponsah, Jonathan Amponsah, Robert S. Tegg, Tamilarasan Thangavel, Calum R. Wilson   +4 more
doaj   +1 more source