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A Deep Learning-Based Model Approach for Quantitative Analysis of Cell Chemotaxis in a Microfluidic Chip [PDF]

Sensors
The rapid and accurate quantitative analysis of cell chemotaxis, which is essential in biology, medicine, and drug development, enables the evaluation of the directional migration capability of cells and the simulation of in vivo cell chemotaxis. However,
Hongxuan Wu, Fei Zhang, Mingji Wei
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Pseudomonas aeruginosa Performs Chemotaxis to the Neurotransmitters Serotonin, Dopamine, Epinephrine and Norepinephrine [PDF]

Microbial Biotechnology
Bacteria use chemotaxis to move to favourable ecological niches. For many pathogenic bacteria, chemotaxis is required for full virulence, particularly for the initiation of host colonisation. There do not appear to be limits to the type of compounds that
Elizabet Monteagudo‐Cascales, Andrea Lozano‐Montoya, Tino Krell   +2 more
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Experimental evolution partially restores functionality of bacterial chemotaxis network with reduced number of components. [PDF]

PLoS Genetics
The chemotaxis signaling pathway, which enables bacteria to follow chemical gradients in their environment, is highly conserved among motile bacteria. It is assumed that Escherichia coli contains the minimal and non-redundant set of protein activities ...
Manika Kargeti, Irina Kalita, Sarah Hoch, Maryia Ratnikava, Wenhao Xu, Bin Ni, Ron L Dy, Remy Colin, Victor Sourjik   +8 more
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C2GAP2 is a common regulator of Ras signaling for chemotaxis, phagocytosis, and macropinocytosis

Frontiers in Immunology, 2022
Phagocytosis, macropinocytosis, and G protein coupled receptor-mediated chemotaxis are Ras-regulated and actin-driven processes. The common regulator for Ras activity in these three processes remains unknown.
Xuehua Xu, Henderikus Pots, Bernd K. Gilsbach, Dustin Parsons, Douwe M. Veltman, Sharmila G. Ramachandra, Haoran Li, Arjan Kortholt, Tian Jin   +8 more
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Membrane Targeting of C2GAP1 Enables Dictyostelium discoideum to Sense Chemoattractant Gradient at a Higher Concentration Range

Frontiers in Cell and Developmental Biology, 2021
Chemotaxis, which is G protein-coupled receptor (GPCR)-mediated directional cell migration, plays pivotal roles in diverse human diseases, including recruitment of leukocytes to inflammation sites and metastasis of cancer.
Xuehua Xu, Smit Bhimani, Henderikus Pots, Xi Wen, Taeck J. Jeon, Arjan Kortholt, Tian Jin   +6 more
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Evolution of Reproductive Division of Labor – Lessons Learned From the Social Amoeba Dictyostelium discoideum During Its Multicellular Development

Frontiers in Cell and Developmental Biology, 2021
The origin of multicellular life from unicellular beings is an epochal step in the evolution of eukaryotes. There are several factors influencing cell fate choices during differentiation and morphogenesis of an organism. Genetic make-up of two cells that
Ranjani Dhakshinamoorthy, Shashi P. Singh   +1 more
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Multiple CheY Proteins Control Surface-Associated Lifestyles of Azospirillum brasilense

Frontiers in Microbiology, 2021
Bacterial chemotaxis is the directed movement of motile bacteria in gradients of chemoeffectors. This behavior is mediated by dedicated signal transduction pathways that couple environment sensing with changes in the direction of rotation of flagellar ...
Elena E. Ganusova, Lam T. Vo, Tanmoy Mukherjee, Gladys Alexandre   +3 more
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Bovine neutrophil chemotaxis to Listeria monocytogenes in neurolisteriosis depends on microglia-released rather than bacterial factors

Journal of Neuroinflammation, 2022
Background Listeria monocytogenes (Lm) is a bacterial pathogen of major concern for humans and ruminants due to its neuroinvasive potential and its ability to cause deadly encephalitis (neurolisteriosis).
Stefano Bagatella, Neda Haghayegh Jahromi, Camille Monney, Margherita Polidori, Flavio Max Gall, Emma Marchionatti, Fabienne Serra, Rainer Riedl, Britta Engelhardt, Anna Oevermann   +9 more
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The Azospirillum brasilense Core Chemotaxis Proteins CheA1 and CheA4 Link Chemotaxis Signaling with Nitrogen Metabolism

mSystems, 2021
Bacterial chemotaxis affords motile bacteria the ability to navigate the environment to locate niches for growth and survival. At the molecular level, chemotaxis depends on chemoreceptor signaling arrays that interact with cytoplasmic proteins to control
Elena E. Ganusova, Lam T. Vo, Paul E. Abraham, Lindsey O’Neal Yoder, Robert L. Hettich, Gladys Alexandre   +5 more
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Cells collectively migrate during ammonium chemotaxis in Chlamydomonas reinhardtii

Scientific Reports, 2023
The mechanisms governing chemotaxis in Chlamydomonas reinhardtii are largely unknown compared to those regulating phototaxis despite equal importance on the migratory response in the ciliated microalga.
Gabela Nelson, Alexis Strain, Atsuko Isu, Alireza Rahnama, Ken-ichi Wakabayashi, Adam T. Melvin, Naohiro Kato   +6 more
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