Results 201 to 210 of about 71,798 (273)

Multitargeted biological actions of polydatin in preventing pseudogout acute attack. [PDF]

Front Mol Biosci
Baggio C, Galozzi P, Damasco A, Lazzarin V, Ravagnan G, Sfriso P, Ramonda R, Punzi L, Pennelli G, Doria A, Luisetto R, Oliviero F.   +11 more
europepmc   +1 more source

Activity and Heterogeneity of Astrocytes in Neurological Diseases: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 6, Issue 9, September 2025.
Astrocytes display heterogeneity in various neurological disorders and behavioral neuropsychiatric disorders. Astrocytes influence the progression of neurological diseases through neuroinflammation, oxidative stress, metabolic abnormalities, intercellular interactions, and a spectrum of other pathophysiological processes.
Shijie Mao, Rui Qiao, Qi Wang, Ling Shen, Daxing Li, Xinchen Huo, Jindou Wang, Kunxuan Liu, Wenjing Chen, Tianhao Zhu, Beicheng Zhang, Shuo Leng, Ying Bai   +12 more
wiley   +1 more source

Activated Interferon‐γ‐Positive T Lymphocytes and Cytokine Signatures in Patients With Postinfectious Cough

MedComm, Volume 6, Issue 9, September 2025.
Postinfectious cough patients have elevated levels of activated IFN‐γ+ T lymphocytes in blood. Postinfectious cough patients exhibit airway inflammatory signatures characterized by activated IFN‐γ+ T‐lymphocytes and elevated levels of IFN‐γ, TNF‐α, IFN‐α, IFN‐β, and IL‐10.
Zheng Deng, Tongtong Song, Wenbin Ding, Wei Luo, Jiaxing Xie, Haodong Wu, Nanshan Zhong, Kefang Lai   +7 more
wiley   +1 more source

Transcriptomic Suppression of Immune and Regenerative Signalling in Skeletal Muscle of Patients with Chronic Kidney Disease

Baker LA, Eastley N, Ashford RU, Denniff M, Graham-Brown M, Watson EL.   +5 more
europepmc   +1 more source

Uncovering common disease mechanisms and critical biomarkers in Crohn's disease with concurrent psoriasis and exploring potential therapeutic agents. [PDF]

PLoS One
Liu T, Zhang X, Chen R, Sun Y, Zhang R, Zhang L, Luo Z, Wang J.   +7 more
europepmc   +1 more source

Antitumor Activity of Tumor‐Infiltrating Neutrophils Revealed by a Syngeneic Mouse Model of Cholangiocarcinoma

Cancer Science, Volume 116, Issue 9, Page 2457-2470, September 2025.
This study developed a genetically engineered and transplantable cholangiocarcinoma (CCA) organoid model in immunocompetent mice to investigate the role of tumor‐infiltrating immune cells in CCA progression. The findings revealed that tumor‐infiltrating neutrophils (TINs) exhibit antitumor activity by directly killing cancer cells through reactive ...
Osamu Sugahara, Daisuke Koga, Takeru Oka, Shigeaki Sugiyama, Reona Wada, Tsunaki Higa, Keiichi I. Nakayama   +6 more
wiley   +1 more source

Chemokines simultaneously bind SARS-CoV-2 nucleocapsid protein RNA-binding and dimerization domains. [PDF]

Virol J
López-Muñoz AD, Yewdell JW.
europepmc   +1 more source

Bosutinib mitigates inflammation in experimental sepsis

European Journal of Clinical Investigation, Volume 55, Issue 9, September 2025.
Abstract Background Sepsis, a leading cause of death globally, lacks targeted and effective treatment. Its pathophysiology involves unbalanced inflammation, marked by a high release of inflammatory mediators, leukocyte recruitment, vascular changes and dysfunction of the nervous and respiratory systems. Src family tyrosine kinases (SFK) play a critical
C. M. C. Cunha, V. H. P. Abreu, V. Estato, G. M. V. Soares, B. P. T. Moraes, G. P. Oliveira, J. D. Silva, P. L. Silva, R. Immler, P. R. Rocco, M. Sperandio, A. R. Silva, P. T. Bozza, H. C. Castro‐Faria‐Neto, C. F. Gonçalves‐de‐Albuquerque   +14 more
wiley   +1 more source

Failure to resolve inflammation contributes to juvenile onset cardiac damage in a mouse model of Duchenne muscular dystrophy. [PDF]

Cell Death Dis
Novak JS, Lischin A, Uapinyoying P, Hindupur R, Moon YJ, Bhattacharya S, Tiufekchiev-Grieco S, Barone V, Mázala DAG, Gamu IH, Walters G, Jaiswal JK.   +11 more
europepmc   +1 more source

Role of Fibroblast‐Immune Crosstalk in Kidney, Lung, and Skin Tertiary Lymphoid Structures

Immunological Reviews, Volume 334, Issue 1, September 2025.
ABSTRACT Tertiary lymphoid structures (TLSs) are organized aggregates of lymphocytes, myeloid cells, and stromal cells that form at sites of inflammation, providing adaptive immune responses outside of secondary lymphoid organs (SLOs). Found in various pathological conditions—including chronic infections, cancer, organ transplantation, autoimmune ...
Amy Cross, Jennifer Shelley, Rebecca Newman, Jessica Strid, Alice E. Denton   +4 more
wiley   +1 more source