Results 211 to 220 of about 99,840 (283)

Multi-omics exploration demonstrated the antidepressant effects of chrysophanol on diabetes-depression comorbidity rats via inflammatory, and neurodegenerative axes. [PDF]

Sci Rep
Hu XJ, Ge D, Ma XL, Yang Y.
europepmc   +1 more source

The Role of Sphingolipid Metabolism and Neuron Death in Ischemic Stroke: A New Perspective from Bioinformatics

Brain and Behavior, Volume 16, Issue 1, January 2026.
First, we evaluated of differences in sphingolipid metabolism using peripheral blood samples from IS patients and healthy controls. Then, we identify the hub genes linking sphingolipid metabolism and neuronal death via modular analysis of protein‐protein interaction networks.
Zhong‐can Chen, Fang‐biao Xu, Sen Hu, Qiang Cui, Hugo Andrade Barazarte, Jing Zhang, Li‐na Suo, Jian‐jun Gu, Jiang‐yu Xue   +8 more
wiley   +1 more source

NETosis and Neutrophil Activity Quantification in Pediatric Patients with Essential Thrombocythemia. [PDF]

Int J Mol Sci
Adamanskaya EA, Korobkin JD, Pshonkin AV, Bogdanov AV, Galkina SV, Podoplelova NA, Yushkova EV, Panteleev MA, Novichkova GA, Smetanina NS, Sveshnikova AN.   +10 more
europepmc   +1 more source

Network and Gene Set Enrichment Analysis of Adipokine Drivers of Prostate Cancer; Unravelling the Mechanistic Link Between Excess Adiposity and Prostate Cancer Risk

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Adiposity‐Based Chronic Disease (ABCD), a novel model housing obesity, insulin resistance, and adipokine‐related inflammation, increases the risk of aggressive prostate cancer (PCa), posttreatment PCa recurrence, and PCa mortality. This paper provides a new network analysis of relevant metabolic drivers to provide insight into the ...
Zachary Dovey, Elena Tomas Bort, Jeffrey I. Mechanick   +2 more
wiley   +1 more source

Targeting neutrophil‐driven immunosuppression: A strategy to overcome immune checkpoint inhibitor resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
TANs drive ICI resistance via antitumour immune remodelling, angiogenesis promotion, and elevation of tumour mutation burden Neutrophil biomarkers (e.g., NLR, TAN abundance) show strong predictive value for ICI response and prognosis. Targeting TAN recruitment, polarization, function and NETosis represents a promising strategy to overcome ICI ...
Ying Ning, Ke Lei, Xinyan Gao, Yan Kong, Yuping Shan, Tian Tian, Zhumei Cui, He Ren   +7 more
wiley   +1 more source

Harnessing biomaterials for tuning inflammation: A neutrophil-centric perspective. [PDF]

Mater Today Bio
Wang QH, Song WZ, Han CY, Yang S, Gao SR, Ai YC, Wang D, Liu YT, Yin WZ.   +8 more
europepmc   +1 more source

Chinese Yam (Dioscorea) Improves Psychiatric Comorbidities of Colitis Mice Through Regulating 5‐HT Metabolism

Food Frontiers, Volume 7, Issue 1, January 2026.
CY alleviates colitis and associated neuropsychiatric symptoms by reducing serum LPS, restoring intestinal barrier integrity, and modulating serotonin metabolism. It inhibits neuroinflammation, improves synaptic function, and normalizes HPA axis hyperactivity via downregulation of HTR2C, offering a multi‐targeted strategy for gut–brain axis dysfunction
Yifan Cui, Yingzhuo Zhou, Xiaoying Zhang, Yinghua Luo, Chen Ma, Li Dong, Xiaosong Hu, Daotong Li, Lin Wang, Fang Chen   +9 more
wiley   +1 more source

<i>ITGA4</i> genetic variants as a predictor of therapeutic responsivity to autoimmune diseases. [PDF]

Front Pharmacol
De Matos MD, Guimenes BD, Pavani GK, Fernandes GG, Montes GC, Fontes-Dantas FL.   +5 more
europepmc   +1 more source

hiPSC‐Derived Astrocytes From Individuals With Schizophrenia Induce a Dystrophic Phenotype in Microglial‐Like Cells

Glia, Volume 74, Issue 1, January 2026.
SCZ astrocytes display an increased pro‐inflammatory profile upon TNF‐α stimulation. Reactive SCZ astrocytes induce microglial‐like cells to assume a dystrophic phenotype. Reactive SCZ astrocytes limit iMGs' synaptoneurosome uptake and migration. ABSTRACT Neuroinflammation, particularly astrocyte reactivity, is increasingly linked to schizophrenia (SCZ)
Pablo L. Cardozo, Chia‐Yi Lee, Juliana P. S. Lacerda, Júlia S. Fahel, Pablo Trindade, Gabriela Vitória, Leonardo Chicaybam, Rafaela C. Cordeiro, Isaque J. S. de Faria, Nathália C. Silva, Yaovi M. H. Todjro, Joana C. do P. Maciel, Martin H. Bonamino, Luciene B. Vieira, Breno F. Cruz, Rodrigo Nicolato, Kristen J. Brennand, Stevens K. Rehen, Fabíola M. Ribeiro   +18 more
wiley   +1 more source

P2Y14 receptor activation and neutrophil signaling: linking inflammation to systemic pathophysiology. [PDF]

Purinergic Signal
da Silva Ebone R, Doleski PH, Jantsch MH, da Silveira RP, Leal DBR.   +4 more
europepmc   +1 more source