Dendritic Cell Migration: An Essential Step in Initiating Adaptive Immunity Across Tissues
ABSTRACT Immune surveillance of tissues is primarily carried out by dendritic cells (DCs), which act as sentinels for the adaptive immune system. To accomplish this task, DCs migrate from tissues to regional lymph nodes, or from blood‐exposed regions of the spleen to the white pulp, to prime T cell responses. DC migration is a tightly regulated process
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Assays of Leukocyte Chemotaxis
Annual Review of Medicine, 1986A number of disorders of leukocyte motility and chemotaxis have been reported clinically. In this paper we present a rational approach for testing cell populations for a defect in leukocyte migration and for defining the cellular basis of any abnormality observed. The principles and difficulties of individual and population-type assays are discussed.
S H, Zigmond, D A, Lauffenburger
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Disorders of Leukocyte Chemotaxis
Pediatric Clinics of North America, 1977The rapid accumulation of inflammatory cells at sites of microbial invasion or neoplastic transformation is a central event in immunologically-mediated host defense. The availability of methodology to accurately quantify leukocyte migration in vitro has allowed the disclosure of previously unrecognized clinical disorders, namely leukocyte dysmotility ...
R, Snyderman, M C, Pike
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