Frontiers in Immunology, 2021 Structural changes in the spleen have been reported in several infectious diseases. In visceral leishmaniasis (VL), a severe parasitic disease caused by Leishmania spp., the loss of white pulp accompanies a severe clinical presentation.
Caroline Vilas Boas de Melo +11 more
doaj +1 more source
Predicting Axonal Response to Molecular Gradients with a Computational Model of Filopodial Dynamics [PDF]
, 2004 Axons are often guided to their targets in the developing nervous system by attractive or repulsive molecular concentration gradients. We propose a computational model for gradient sensing and directed movement of the growth cone mediated by filopodia ...
Caton A. +3 more
core +3 more sources
How Have Leukocyte In Vitro Chemotaxis Assays Shaped Our Ideas about Macrophage Migration?
Biology, 2020 Macrophage chemotaxis is crucial during both onset and resolution of inflammation and unique among all leukocytes. Macrophages are able to switch between amoeboid and mesenchymal migration to optimise their migration through 3D environments.
Agata N. Rumianek, David R. Greaves
doaj +1 more source
Genome-wide gene expression profiling of stress response in a spinal cord clip compression injury model. [PDF]
, 2013 BackgroundThe aneurysm clip impact-compression model of spinal cord injury (SCI) is a standard injury model in animals that closely mimics the primary mechanism of most human injuries: acute impact and persisting compression.
Boutros, Paul C +5 more
core +3 more sources
Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5
Mediators of Inflammation, 1993 Human recombinant lipocortins (LCT) 1 and 5 have been expressed in a yeast secretion vector and purified by ion exchange chromatography. The action of the proteins has been investigated in two models of experimental acute inflammation in the rat ...
C. Becherucci +4 more
doaj +1 more source
A PKC-MARCKS-PI3K regulatory module links Ca2+ and PIP3 signals at the leading edge of polarized macrophages. [PDF]
PLoS ONE, 2018 The leukocyte chemosensory pathway detects attractant gradients and directs cell migration to sites of inflammation, infection, tissue damage, and carcinogenesis.
Brian P Ziemba, Joseph J Falke
doaj +1 more source
Reciprocal Inhibition of Adiponectin and Innate Lung Immune Responses to Chitin and Aspergillus fumigatus [PDF]
, 2019 Chitin is a structural biopolymer found in numerous organisms, including pathogenic fungi, and recognized as an immune-stimulating pathogen associated molecular pattern by pattern recognition molecules of the host immune system.
Amarsaikhan, Nansalmaa +6 more
core +4 more sources
BMC Genomics, 2022 Background Disease emergence and production loss caused by cattle tick infestations have focused attention on genetic selection strategies to breed beef cattle with increased tick resistance.
Emily F. Mantilla Valdivieso +8 more
doaj +1 more source
Concepts of GPCR-controlled navigation in the immune system
, 2019 G-protein-coupled receptor (GPCR) signaling is essential for the spatiotemporal control of leukocyte dynamics during immune responses. For efficient navigation through mammalian tissues, most leukocyte types express more than one GPCR on their surface ...
Boneschansker L +26 more
core +1 more source
Identification of an alternative G{alpha}q-dependent chemokine receptor signal transduction pathway in dendritic cells and granulocytes [PDF]
, 2007 CD38 controls the chemotaxis of leukocytes to some, but not all, chemokines, suggesting that chemokine receptor signaling in leukocytes is more diverse than previously appreciated.
Borchers, Michael T. +7 more
core +2 more sources