Results 21 to 30 of about 404,279 (303)

TRPM2 ion channels steer neutrophils towards a source of hydrogen peroxide

Scientific Reports, 2021
Neutrophils must navigate accurately towards pathogens in order to destroy invaders and thus defend our bodies against infection. Here we show that hydrogen peroxide, a potent neutrophil chemoattractant, guides chemotaxis by activating calcium-permeable ...
Hassan Morad, Suaib Luqman, Chun-Hsiang Tan, Victoria Swann, Peter A. McNaughton   +4 more
doaj   +1 more source

A new class of protein sensor links spirochete pleomorphism, persistence, and chemotaxis

mBio, 2023
Pathogenic spirochetes can alter their morphologies and behaviors to infect and survive within their hosts. Previous reports demonstrate that the formation of the so-called “round bodies” and biofilms, and chemotaxis are involved in spirochete ...
A. R. Muok, K. Kurniyati, C. K. Cassidy, F. A. Olsthoorn, D. R. Ortega, A. Sidi Mabrouk, C. Li, A. Briegel   +7 more
doaj   +1 more source

Modelling cell movement and chemotaxis pseudopod based feedback [PDF]

, 2011
A computational framework is presented for the simulation of eukaryotic cell migration and chemotaxis. An empirical pattern formation model, based on a system of non-linear reaction-diffusion equations, is approximated on an evolving cell boundary using ...
Insall, Robert H., Mackenzie, John, Neilson, Matthew Paterson, Webb, Steven   +3 more
core   +1 more source

Drug targeting to decrease cardiotoxicity – determination of the cytotoxic effect of GnRH-based conjugates containing doxorubicin, daunorubicin and methotrexate on human cardiomyocytes and endothelial cells

Beilstein Journal of Organic Chemistry, 2018
Background: Cardiomyopathy induced by the chemotherapeutic agents doxorubicin and daunorubicin is a major limiting factor for their application in cancer therapy.
Livia Polgár, Eszter Lajkó, Pál Soós, Orsolya Láng, Marilena Manea, Béla Merkely, Gábor Mező, László Kőhidai   +7 more
doaj   +1 more source

Metabolic products of soluble epoxide hydrolase are essential for monocyte chemotaxis to MCP-1 in vitro and in vivo

Journal of Lipid Research, 2013
Monocyte chemoattractant protein-1 (MCP-1)-induced monocyte chemotaxis is a major event in inflammatory disease. Our prior studies have demonstrated that MCP-1-dependent chemotaxis requires release of arachidonic acid (AA) by activated cytosolic ...
Suman Kundu, Talat Roome, Ashish Bhattacharjee, Kevin A. Carnevale, Valentin P. Yakubenko, Renliang Zhang, Sung Hee Hwang, Bruce D. Hammock, Martha K. Cathcart   +8 more
doaj   +1 more source

Chemotactic network responses to live bacteria show independence of phagocytosis from chemoreceptor sensing

eLife, 2017
Aspects of innate immunity derive from characteristics inherent to phagocytes, including chemotaxis toward and engulfment of unicellular organisms or cell debris.
Netra Pal Meena, Alan R Kimmel
doaj   +1 more source

The Novel Protein Cj0371 Inhibits Chemotaxis of Campylobacter jejuni

Frontiers in Microbiology, 2018
cj0371 is a novel gene that is associated with Campylobacter jejuni virulence, and an isogenic mutant of cj0371 showed hyper chemotaxis and motility. Chemotactic motility is an important virulence factor and is involved in C.
Xueqing Du, Ke Kong, Hong Tang, Haiyan Tang, Xinan Jiao, Jinlin Huang   +5 more
doaj   +1 more source

Chytridiomycosis of marine diatoms : the role of stress physiology and resistance in parasite-host recognition and accumulation of defense molecules [PDF]

, 2017
Little is known about the role of chemotaxis in the location and attachment of chytrid zoospores to potential diatom hosts. Hypothesizing that environmental stress parameters affect parasite-host recognition, four chytrid-diatom tandem cultures ...
Karsten, Ulf, Küpper, Frithjof C, Scholz, Bettina, Vyverman, Wim, Ólafsson, Halldór   +4 more
core   +3 more sources

Control of human endometrial stromal cell motility by PDGF-BB, HB-EGF and trophoblast-secreted factors [PDF]

, 2013
Human implantation involves extensive tissue remodeling at the fetal-maternal interface. It is becoming increasingly evident that not only trophoblast, but also decidualizing endometrial stromal cells are inherently motile and invasive, and likely ...
A Brar, A Samalecos, A Stavreus-Evers, AA Brahmbhatt, Ana-Maria Bamberger, Anja Wolf, Annemarie Samalecos, AT Fazleabas, B Cloke, B Gellersen, B Gellersen, BA Lessey, Birgit Gellersen, C Ferretti, C Fischer, C Gaggioli, Charlotte H. E. Weimar, CHE Weimar, CM Boomsma, CP Thomas, D Gentilini, D Gentilini, D Haouzi, DE Clark, EE Sander, ER Norwitz, F Chang, F Llorens, F Lyall, G Gaus, G Teklenburg, G Teklenburg, GE Lash, GE Lash, GJ Burton, H Funayama, H Matsumoto, H Xie, HJ Lim, HJ Yoo, I Ihnatovych, IY Yotova, J Anacker, J Baulida, J Fiedler, JJ Brosens, JJ Brosens, JW Tullai, JX Zhu, K Chobotova, K Kawada, K Red-Horse, K Roepstorff, LA Salamonsen, M Bilban, M Bilban, M Cohen, M Gonzalez, M Knöfler, M Knöfler, M Salker, Maren Schwenke, Martin Knöfler, Meijing Wang, Michelle Kruse, MW Maijenburg, Nick S. Macklon, NJ Hannan, NJ Hannan, P Burke, P Jessmon, P Jessmon, P Kaufmann, Philipp Velicky, R Apps, RE Leach, RE Leach, RE Leach, RJ Petrie, RL Kendall, RN Popovici, S Grewal, S Grewal, SK Mitra, Y Jiang, Y Yamazaki   +85 more
core   +3 more sources

On the fractional Fisher information with applications to a hyperbolic-parabolic system of chemotaxis [PDF]

, 2016
We introduce new lower bounds for the fractional Fisher information. Equipped with these bounds we study a hyperbolic-parabolic model of chemotaxis and prove the global existence of solutions in certain dissipation ...
Granero-Belinchón, Rafael
core   +5 more sources