Results 101 to 110 of about 19,115 (229)

Targeting the Membrane‐Embedded Rhomboid Protease GlpG: A Multimodal Strategy for Inhibitor Discovery and Mechanistic Insight

Angewandte Chemie, Volume 138, Issue 10, 2 March 2026.
Created in BioRender. Bohg, C. (2026) https://BioRender.Com/ vi9hi4f. Rhomboid proteases are a mechanistically unique and evolutionarily conserved protein family. Despite their pharmacological relevance, the development of selective inhibitors has lagged behind that of soluble proteases.
Claudia Bohg, Yurii Dubanych, Spyridon Kosteletos, Taoran Xiao, Martin Neuenschwander, Tillmann Utesch, Michael Lisurek, Carl Öster, Andreas Oder, Carola Seyffarth, Kathrin Bach, Denise‐Liù Gracias Leone, František Filandr, Marc Wegert, Sascha Lange, Henry Sawczyc, Jens Peter von Kries, Christian P. R. Hackenberger, Edgar Specker, Han Sun, Kvido Stříšovský, Adam Lange   +21 more
wiley   +2 more sources

DNA barcoding and LC-MS metabolite profiling of the lichen-forming genus Melanelia: Specimen identification and discrimination focusing on Icelandic taxa [PDF]

, 2017
Taxa in the genus Melanelia (Parmeliaceae, Ascomycota) belong to a group of saxicolous lichens with brown to black foliose thalli, which have recently undergone extensive changes in circumscription.
Eiríksson, Finnur Freyr, Heiðmarsson, Starri, Olafsdottir, Elin Soffia, Omarsdottir, Sesselja, Thorsteinsdóttir, Margrét, Xu, Maonian   +5 more
core   +3 more sources

Comprehensive transduceromic profiling of NOP receptor ligands at different Gα subunits

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose The nociceptin/orphanin FQ (N/OFQ) peptide receptor (NOP) is an opioid receptor family member with distinct pharmacology and broad therapeutic potential. NOP receptors regulate functions such as nociception, stress reactivity, reward, mood, autonomic tone, immunity and sleep/wake cycle.
Davide Malfacini, Riccardo Camilotto, Michele Maritan, Erika Morrone, Stephen Afriyie Boateng, Anna Vacilotto, Salvatore Pacifico, Remo Guerrini, Nurulain T. Zaveri, Girolamo Calo'   +9 more
wiley   +1 more source

Phenotypic plasticity of nest-mate recognition cues in formica exsecta ants [PDF]

, 2019
It is well established that many ant species have evolved qualitatively distinct species-specific chemical profile that are stable overlarge geographical distances.
A Bonavita-Cougourdan, A Dosmann, Adam G. Hart, C Errard, C Errard, C Wicker-Thomas, D Morgan, E Provost, F Esponda, F Menzel, Falko P. Drijfhout, FJ Guerrieri, H Helanterä, HE Vuong, JD Slone, K Matsuura, KR Sharma, M Spivak, ML Muscedere, N Chaline, NF Carlin, P Newey, PS Newey, R Boulay, R Yamaoka, RH Crozier, RW Howard, SJ Martin, SJ Martin, SJ Martin, SJ Martin, SJ Martin, SJ Martin, SJ Sturgis, Stephen J. Martin, T Akino, T Otte, TD Wyatt, VJ Emery, W Kostowski   +39 more
core   +5 more sources

Deciphering the biosynthetic pathways of lichen acids

New Phytologist, EarlyView.
Summary Depsides and depsidones are polyketide‐derived lichen acids widely distributed in lichen thalli, yet the biosynthetic gene clusters (BGCs) responsible for their production remain poorly understood. To address this gap, we investigated the diversity and evolutionary relationships of polyketide BGCs in lichens.
Wonyong Kim, Tânia Keiko Shishido, Huong T. Pham, Kyo Bin Kang, Rundong Liu, Matti Wahlsten, Jérôme Collemare, Hyun Park, Soon‐Ok Oh, Hyung‐Ho Ha, Hangun Kim, Jae‐Seoun Hur   +11 more
wiley   +1 more source

Análise e discriminação de quimiotipos de Lippia graveolens H.B.K. da Guatemala por microextração em fase sólida, CG-EM e análise multivariada

Química Nova, 2012
SPME-GC-MS, PCA and HCA multivariate techniques were used in order to evaluate their applicability to discriminate the three chemotypes (thymol, carvacrol and mixed) described for L. graveolens of Guatemala. The leaves of L.
Juan Francisco Pérez Sabino, Max Mérida Reyes, Christian Daniel Farfán Barrera, Antonio Jorge Ribeiro da Silva   +3 more
doaj   +1 more source

An unusual flavin-dependent halogenase from the metagenome of the marine sponge Theonella swinhoei WA [PDF]

, 2017
The authors thank EU BlueGenics (Seventh Framework Programme, Collaborative project “BlueGenics”, Grant no. 311848 RJMG and JP), the SNF (Grant no.205321_165695 to JP), the Helmut Horten Foundation (JP), and ERAIB (Grant no.
Agustinus R. Uria, Daniela Milbredt, Duncan R. M. Smith, Eric J. N. Helfrich, Gribble G. W., Grüschow S., Herrera-Rodriguez L. N., Jörn Piel, Karl-Heinz van Pée, Rebecca J. M. Goss   +9 more
core   +4 more sources

Resurrected Ancestral Cannabis Enzymes Unveil the Origin and Functional Evolution of Cannabinoid Synthases

Plant Biotechnology Journal, EarlyView.
ABSTRACT Cannabinoids, such as tetrahydrocannabinolic acid (THCA), cannabidiolic acid (CBDA) and cannabichromenic acid (CBCA), are bioactive and medicinally relevant compounds found in the cannabis plant (Cannabis sativa L.). These three compounds are synthesised from a single precursor, cannabigerolic acid (CBGA), through regioselective reactions ...
Cloé Villard, Idil Baser, Arjen C. van de Peppel, Katarina Cankar, M. Eric Schranz, Robin van Velzen   +5 more
wiley   +1 more source

Pharmacognosy and Chemotypes of Passionflower (Passiflora incarnata L.)

Biological and Pharmaceutical Bulletin, 2010
Passionflower (Passiflora incarnata L.) is used in phytotherapy as a mild sedative and anxiolytic agent. In the literature it is clear this plant shows considerable qualitative and quantitative variability with respect to its content of C-glycosyl flavones, some of which are used as marker compounds for extracts.
Wohlmuth, Hans, Penman, Kerry G, Pearson, Tanya, Lehmann, Reginald P   +3 more
openaire   +3 more sources

Phylogenetic analysis indicates transitions from vegetative to sexual reproduction in the Lobaria retigera group (Lecanoromycetidae, Ascomycota) [PDF]

, 2017
Phylogenetic relationships among the hypothetical species pairs Lobaria kurokawae / L. retigera and L. pseudopulmonaria / L. isidiosa were investigated based on TLC techniques and the phylogenetic analysis of the internal transcribed spacers (ITS) nrDNA.
CHABANENKO, Svetlana, CORNEJO, Carolina, SCHEIDEGGER, Christoph   +2 more
core