Results 11 to 20 of about 19,115 (229)

Antitumor Cannabinoid Chemotypes: Structural Insights [PDF]

Frontiers in Pharmacology, 2019
Cannabis has long been known to limit or prevent nausea and vomiting, lack of appetite, and pain. For this reason, cannabinoids have been successfully used in the treatment of some of the unwanted side effects caused by cancer chemotherapy. Besides their palliative effects, research from the past two decades has demonstrated their promising potential ...
Morales, Paula, Jagerovic, Nadine
openaire   +4 more sources

Novel Toxoplasma gondii inhibitor chemotypes [PDF]

Parasitology International, 2018
We profiled three novel T. gondii inhibitors identified from an antimalarial phenotypic high throughput screen (HTS) campaign: styryl 4-oxo-1,3-benzoxazin-4-one KG3, tetrahydrobenzo[b]pyran KG7, and benzoquinone hydrazone KG8. These compounds inhibit T.
A G, Sanford, T T, Schulze, L P, Potluri, R M, Hemsley, J J, Larson, A K, Judge, S J, Zach, X, Wang, S A, Charman, J L, Vennerstrom, P H, Davis   +10 more
openaire   +2 more sources

Heterogeneity of iridoid biosynthesis in catmints: Molecular background in a phylogenetic context. [PDF]

J Integr Plant Biol
Evolutionary gains and losses of key biosynthetic genes likely resulting from multiple independent evolutionary events explain why certain Nepeta (catnip) species produce both the active, cat‐attracting nepetalactones and sugar‐bound iridoids, while others make only the sugar‐bound forms, and some have lost iridoid production entirely.
Banjanac T, Milutinović M, Matekalo D, Popović N, Petrović L, Gašić U, Skorić M, Šiler B, Lukić T, Stupar A, Dmitrović S, Nestorović Živković J, Filipović B, Božunović J, Todorović M, Mišić D.   +15 more
europepmc   +2 more sources

Cell‐Based Identification of New IDO1 Modulator Chemotypes [PDF]

Angewandte Chemie, 2021
AbstractThe immunoregulatory enzyme indoleamine‐2,3‐dioxygenase (IDO1) strengthens cancer immune escape, and inhibition of IDO1 by means of new chemotypes and mechanisms of action is considered a promising opportunity for IDO1 inhibitor discovery. IDO1 is a cofactor‐binding, redox‐sensitive protein, which calls for monitoring of IDO1 activity in its ...
Elisabeth Hennes, Philipp Lampe, Lara Dötsch, Nora Bruning, Lisa‐Marie Pulvermacher, Sonja Sievers, Slava Ziegler, Herbert Waldmann   +7 more
openaire   +5 more sources

Foeniculum vulgare Miller, a New Chemotype from Montenegro [PDF]

Plants, 2021
Previous studies relating to prolonged and fractionated distillation procedures highlighted essential oils’ (EOs) chemical composition to be significantly dependent on the extraction duration and harvesting time. As a continuation, a hydrodistillation procedure was applied to ripe fruit material of fennel, Foeniculum vulgare Miller (Apiaceae ...
Mijat Božović, Stefania Garzoli, Svetlana Vujović, Filippo Sapienza, Rino Ragno   +4 more
openaire   +4 more sources

Molecular, morphological, and phytochemical evidence for a broad species concept of Plagiochila bifaria (Hepaticae) [PDF]

, 2004
Debate over the synonymy of the European Plagiochila killarniensis and the Neotropical P bifaria of R sect. Arrectae has focused on differences in secondary metabolite composition.
Feldberg, K., Groth, H., Heinrichs, J., Lindner, M., Rycroft, D.S.   +4 more
core   +1 more source

Commercial biocontrol agents reveal contrasting comportments against two mycotoxigenic fungi in cereals: Fusarium Graminearum and Fusarium Verticillioides [PDF]

, 2020
The aim of this study was to investigate the impact of commercialized biological control agents (BCAs) against two major mycotoxigenic fungi in cereals, Fusarium graminearum and Fusarium verticillioides, which are trichothecene and fumonisin producers ...
Durand, Noel, Foutana, Angélique, Martinez, Véronique, Pellan, Lucile, Schorr-Galindo, Sabine, Strub, Caroline   +5 more
core   +1 more source

A COMPARISON OF DIFFERENT LIPOPOLYSACCHARIDE CHEMOTYPES FROM ESCHERICHIA COLI AND SALMONELLA UPON SYNTHESIS OF TNFα AND IL-6 BY MACROPHAGE-LIKE THP-1 CELLS

Медицинская иммунология, 2014
. Present study was performed to investigate the influence of polysaccharide fragment or lipid A upon induction of TNFα and IL-6 cytokines. The study was performed with human THP-1 monocytic leukemia cells that were induced to differentiate into ...
E. V. Voloshina, S. V. Zubova, S. V. Prokhorenko, N. I. Kosjakova, I. R. Prokhorenko   +4 more
doaj   +1 more source

Essential Oil Composition and Stable Isotope Profile of Cultivated Ocimum campechianum Mill. (Lamiaceae) from Peru

Molecules, 2022
Ocimum campechianum Mill. (Peruvian basil) is an essential oil-bearing plant of the Lamiaceae family. Volatile oil produced through steam distillation of Peruvian basil was examined to establish the aromatic and stable isotope profiles of samples (n = 9)
Tyler M. Wilson, Brett J. Murphy, Adrian Abad, Chris Packer, Ariel Poulson, Richard E. Carlson   +5 more
doaj   +1 more source

Machine learning approaches to study the structure-activity relationships of LpxC inhibitors

EXCLI Journal : Experimental and Clinical Sciences, 2023
Antimicrobial resistance (AMR) has emerged as one of the global threats to human health in the 21st century. Drug discovery of inhibitors against novel targets rather than conventional bacterial targets has been considered an inevitable strategy for the ...
Tianshi Yu, Li Chuin Chong, Chanin Nantasenamat, Nuttapat Anuwongcharoen, Theeraphon Piacham   +4 more
doaj   +1 more source