Results 81 to 90 of about 19,115 (229)

The Emerging Fusarium graminearum NA3 Population Produces High Levels of Mycotoxins in Wheat and Barley

Toxins
Fusarium graminearum (Fg) is the primary causal agent of Fusarium head blight (FHB) in wheat, barley, and other small grains in North America and worldwide.
Nicholas A. Rhoades, Susan P. McCormick, Martha M. Vaughan, Guixia Hao   +3 more
doaj   +1 more source

Diterpenoid Diversity across Land Plants

Helvetica Chimica Acta, EarlyView.
Here we bridge the knowledge of diterpene chemical diversity, biosynthesis, and evolution from nonvascular mosses and liverworts to that known from vascular plants. ABSTRACT The diverse array of diterpenoid natural products stems from the ease of manipulating the promiscuity of diterpene cyclases.
Anita Berg, Chad K. Papenfuhs, Amy E. Fraley   +2 more
wiley   +1 more source

Ultra-large library docking for discovering new chemotypes [PDF]

Nature, 2019
Despite intense interest in expanding chemical space, libraries containing hundreds-of-millions to billions of diverse molecules have remained inaccessible. Here we investigate structure-based docking of 170 million make-on-demand compounds from 130 well-characterized reactions. The resulting library is diverse, representing over 10.7 million scaffolds
Lyu, Jiankun, Wang, Sheng, Balius, Trent E, Singh, Isha, Levit, Anat, Moroz, Yurii S, O’Meara, Matthew J, Che, Tao, Algaa, Enkhjargal, Tolmachova, Kateryna, Tolmachev, Andrey A, Shoichet, Brian K, Roth, Bryan L, Irwin, John J   +13 more
openaire   +4 more sources

Effect of Habitat Height on Artemisinin Production and the Existence of Chemotype in Artemisia Species

World Journal of Traditional Chinese Medicine
Objective: The study aimed to explore novel artemisinin plant sources as an alternative to Artemisia annua, to study the effect of habitat height on artemisinin concentration, and to find out the existence of chemotypes in Artemisia species.
Abdul Mannan, Usman Ali Shah Sherani, Muhammad Ihtisham Umar, Shujaat Ali Khan, Ghulam Murtaza   +4 more
doaj   +1 more source

Toll-Like Receptor 4 Signaling in the Ileum and Colon of Gnotobiotic Piglets Infected with Salmonella Typhimurium or Its Isogenic ∆rfa Mutants

Toxins, 2020
Salmonella Typhimurium is a Gram-negative bacterium that causes enterocolitis in humans and pigs. Lipopolysaccharide (LPS) is a component of the outer leaflet of Gram-negative bacteria that provokes endotoxin shock.
Igor Splichal, Ivan Rychlik, Iva Splichalova, Daniela Karasova, Alla Splichalova   +4 more
doaj   +1 more source

Quali-quantitative analysis of eight Rosmarinus officinalis essential oils of different origin. First report. [PDF]

, 2012
Aim. It is well known that the pharmacological activity of essential oils depends on their major components, which may vary enormously. The aim of the present study was to determine the chemical composition of samples of essential oil of rosemary of ...
Daniela, Giachetti, Elisabetta, Miraldi, Gaia, Mazzoni, Marco, Biagi   +3 more
core   +2 more sources

Integrated characterization of Greek fennel genotypes through morpho‐agronomical characteristics, yield components and phytochemical compounds

JSFA reports, Volume 5, Issue 3, Page 91-103, March 2025.
Abstract Background Fennel (Foeniculum vulgare Mill.) is a widely cultivated vegetable and aromatic‐medicinal plant. In this research, field studies assessed 12 fennel genotypes of diverse origin, comprising 10 Greek accessions and two European commercial varieties, focusing on their morpho‐agronomical traits, phenolic compounds and antioxidant ...
Kalliopi I. Kadoglidou, Christos Maliachovas, Parthenopi Ralli, Maria Irakli, Nektaria Tsivelika, Athanasios G. Mavromatis, Paschalina Chatzopoulou   +6 more
wiley   +1 more source

Historical Planktothrix diversity across seven Norwegian lakes implies environmentally driven niche differentiation

Frontiers in Ecology and Evolution, 2015
Non-ribosomal synthetase-produced cyanopeptoline oligopeptides enables differentiation of subpopulations of the cyanobacterial genus Planktothrix into chemotypes. It is unknown what influences the population structuring of these chemotypes.
Marcia eKyle, Tom eAndersen, Sigrid eHaande, Thomas eRohrlack   +3 more
doaj   +1 more source

Foeniculum sanguineum Triano y A. Pujadas (Apiaceae) nueva especie del suroeste de la Región Mediterránea [PDF]

, 2015
Foeniculum sanguineum Triano & A. Pujadas, sp. nov., from the south western Mediterranean Region (Spain & Morocco) is described. Its characterization and a comparative study with the related species Foeniculum vulgare Mill., has been carried out through ...
Anaya, Josefa, Grande, Manuel, Hernández, Pilar, Pujadas Salvà, Antonio J., Raposo, César, Torres, Pascual, Triano Muñoz, Enrique   +6 more
core   +3 more sources

Disarming the Hsp70–Bim Alliance: Small‐Molecule and Peptidic Disruptors of a Chaperone‐Apoptotic Switch in Cancer

ChemistryOpen, EarlyView.
Targeting a nucleotide‐sensitive groove on Hsp70 that binds the Bim BH3 helix, we integrate structures, biophysics, and SAR from peptides, fragments, and phenalene‐dicarbonitrile “wedges.” These disrupt the Hsp70–Bim complex with sub‐µM cellular engagement and in vivo activity while sparing Hsp90/mortalin.
Emadeldin M. Kamel, Mohammed Al‐zharani, Lina M. Alneghery, Noha A. Ahmed, Faris F. Aba Alkhayl, Al Mokhtar Lamsabhi   +5 more
wiley   +1 more source