Results 71 to 80 of about 16,871 (260)

Applying sterols and bile acids as biomarkers for identifying human versus wild animals' faecal traces in cave sediments at archaeological sites

Archaeometry, Volume 67, Issue 4, Page 1022-1039, August 2025.
Abstract Faecal biomarkers are used to trace and identify the source of faecal matter at various types of archaeological sites. Until now, the focus has been centred on humans and domesticated animals. However, in caves, it's wild animals that play a role in the deposition of organic matter.
Natalia Gryczewska, Marcin Sulwiński, Piotr Chibowski, Maciej T. Krajcarz, Marcin Zegarek, Małgorzata Kot, Andrea Pereswiet‐Soltan, Karol Szymczak, Małgorzata Suska‐Malawska   +8 more
wiley   +1 more source

Farnesoid X Receptor and its ligands inhibit the function of platelets [PDF]

, 2016
Objective - While initially seemingly paradoxical due to the lack of nucleus, platelets possess a number of transcription factors that regulate their function through DNA-independent mechanisms.
Ali, Marfoua S., Bishop-Bailey, David, Bye, Alex P., Dombrowicz, David, Dorchies, Emilie, Flora, Gagan D., Gibbins, Jonathan M., Kriek, Neline, Molendi-Coste, Olivier, Moraes, Leonardo A., Sage, Tanya, Sasikumar, Parvathy, Staels, Bart, Unsworth, Amanda J., Vaiyapuri, Sakthivel   +14 more
core   +2 more sources

pH-Solubility relations of chenodeoxycholic and ursodeoxycholic acids: physical-chemical basis for dissimilar solution and membrane phenomena.

Journal of Lipid Research, 1980
We examined by titration the electrochemical properties, apparent pK (pK'a), precipitation pH, and undissociated bile acid solubilities of chenodeoxycholic acid and its 7 beta epimer, ursodeoxycholic acid and their glycine conjugates as functions of a ...
H Igimi, M C Carey
doaj  

Fermented bile improved growth performance and intestine health by altering metabolic profiles and intestinal microbes in Chinese perch, Siniperca chuatsi

Journal of the World Aquaculture Society, Volume 56, Issue 4, August 2025.
Abstract A type of fermented bile acid (BA) named 170HDa was produced using a biological method, and its impacts on growth performance, metabolism, and intestinal microbes in Chinese perch (Siniperca chuatsi) were investigated. Seven experimental diets were established, including treatment groups supplemented with 0.02%–0.06% 170HDa (GN1‐GN5), a ...
Qing Guo, Yutao Liu, Lu Zhao, Wenwen Liu, Zhihang Zhu, Houfa Zhao, Cuimin Mu, Xuepeng Wang   +7 more
wiley   +1 more source

The bile acid TGR5 membrane receptor: From basic research to clinical application [PDF]

, 2014
The TGR5 receptor (or GP-BAR1, or M-BAR) was characterized ten years ago as the first identified G-coupled protein receptor specific for bile acids.
Duboc, Henri, Hofmann, Alan F., Taché, Yvette   +2 more
core   +1 more source

Bile acid formation in man: metabolism of 7α-hydroxy-4-cholesten-3-one in bile fistula patients

Journal of Lipid Research, 1973
7α-Hydroxy-4-cholesten-3-one is thought to be an intermediate in human bile acid synthesis. This conclusion is based on in vivo experiments in animals and on in vitro studies in which homogenates of animal and human livers were used. To further establish
Russell F. Hanson, Peter D. Klein, Gale C. Williams   +2 more
doaj  

Pathogenesis, Non‐Invasive Assessments and Treatment of Hepatic Fibrosis in Autoimmune Liver Diseases

Liver International, Volume 45, Issue 8, August 2025.
ABSTRACT Background and Aims Autoimmune liver diseases (AILD), including autoimmune hepatitis (AIH), primary biliary cholangitis (PBC) and primary sclerosing cholangitis (PSC), can lead to progressive liver fibrosis, development of cirrhosis, decompensation, hepatocellular carcinoma (HCC), and need for liver transplantation (LT).
Ellina Lytvyak, Gideon Hirschfield, Devika Shreekumar, Yu Jun Wong, Aldo J. Montano‐Loza   +4 more
wiley   +1 more source

The economy of the enterohepatic circulation of bile acids in the baboon. 2. Regulation of bile acid synthesis by enterohepatic circulation of bile acids.

Journal of Lipid Research, 1984
Isotope dilution within bile acid pools and radiochemical assessment of cholesterol oxidation to bile acids were methods used to measure short-term feedback regulation of bile acid synthesis in baboons with controlled enterohepatic circulations ...
R N Redinger
doaj  

Effectiveness and Safety of Personalized Cholic Acid Treatment in Patients With Bile Acid Synthesis Defects

Journal of Inherited Metabolic Disease, Volume 48, Issue 4, July 2025.
ABSTRACT Bile acid synthesis defects (BASDs) comprise a group of rare, often severe, metabolic disorders. Bile acid replacement therapy decreases toxic bile acid intermediates production and improves biochemical profiles, potentially delaying or stabilizing disease progression.
Yasmin Polak, Elles Marleen Kemper, Marc Engelen, Femke C. C. Klouwer, Kevin Berendse, Frédéric M. Vaz, Bart G. P. Koot, Eleonora (Noortje) L. Swart, Carla E. M. Hollak   +8 more
wiley   +1 more source

Bile acid synthesis in HepG2 cells: effect of cyclosporin

Journal of Lipid Research, 1994
The hypothesis that cyclosporin specifically affects the pathway of bile acid synthesis that begins with 27-hydroxylation of cholesterol was evaluated in HepG2 cells, which synthesize chenodeoxycholic acid and cholic acid from endogenous 7 alpha ...
J Levy, K Budai, N B Javitt
doaj