Results 41 to 50 of about 7,881 (303)
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
REGIONAL MANAGEMENT SYSTEM MODEL IN EDUCATING GIFTED CHILDREN
Sovremennye Issledovaniâ Socialʹnyh Problem, 2018 Subject: modeling and managing extended support and development of gifted children in their education. Aim: the rationale and creation of a regional management system model of activities for educating gifted children, which will enable their real and ...
Galina Leonidovna Parfenova +1 more
doaj +1 more source
The Gift of Feedback: Child HCAHPS [PDF]
Pediatrics, 2017 * Abbreviations: CMS — : Centers for Medicare and Medicaid Services HCAHPS — : Hospital Consumer Assessment of Healthcare Providers and Systems Instruments to measure and assess patient experience are widely used in US hospitals.
Kerry L, Rosen, Steven, Allen
openaire +2 more sources
FEBS Open Bio, EarlyView.IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo +6 more
wiley +1 more source
A Depolarizing Leak in Sodium Bicarbonate Cotransporter NBCe1 Causes Brain Edema
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objectives SLC4A4 encodes electrogenic sodium bicarbonate cotransporter NBCe1, prominently expressed in kidney and brain. Recessive loss‐of‐function variants in SLC4A4 cause proximal renal tubular acidosis, no brain edema. In the brain, NBCe1 is expressed by astrocytes, where it regulates pH and mediates astrocyte volume changes.
Quinty Bisseling +16 more
wiley +1 more source
A 35-year comparison of children labelled as gifted, unlabelled as gifted and average-ability
Revista Educação Especial, 2014 http://dx.doi.org/10.5902/1984686X14273Why are some children seen as gifted while others of identical ability are not? To find out why and what the consequences might be, in 1974 I began in England with 70 children labelled as gifted.
Joan Freeman
doaj +1 more source
Determining the best possible programming options for gifted and talented students in small rural school districts [PDF]
, 2002 Plan BThe education of gifted and talented students is an area that has long been neglected in public education systems. Due to extreme demands on the educational system, special programs often do not receive the attention they need and deserve. This has
Schneider, Ann Keller
core
Role of primary healthcare providers in supporting a gifted child
, 2023 Background Giftedness in children relates to high potential, whereas talent relates to high achievement. The concept of giftedness can be perplexing for those involved in caring for and supporting a gifted child.
Steven Ronksley-Pavia +3 more
core +1 more source
Elevated Connectivity During Language Processing Is Associated With Cognitive Performance in SeLECTS
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Self‐Limited Epilepsy with Centrotemporal Spikes (SeLECTS) is associated with language impairments despite seizures originating in the motor cortex, suggesting aberrant cross‐network interactions. Here we tested whether functional connectivity in SeLECTS during language tasks predicts language performance.
Wendy Qi +8 more
wiley +1 more source