Results 81 to 90 of about 1,737,866 (345)

Timing Mechanotransduction: Mechanically Dynamic Biomaterials Reveal the Temporal Hierarchy of YAP/TAZ Control Nodes

Advanced Science, EarlyView.
This work develops dynamically softening polyacrylamide hydrogels for time‐resolved imaging during continuous mechanical transitions. The study revealed that mechanotransduction is biphasic; YAP/TAZ inactivation is driven by early loss of the nucleocytoskeletal continuum connecting subnuclear adhesions, F‐actin, and the nuclear envelope, coupled with ...
Alessandro Gandin, Giada Vanni, Veronica Torresan, Margherita Pelosin, Rebecca Busetto, Anna Citron, Ambela Suli, Paolo Contessotto, Carlo Albanese, Francesca Zanconato, Tito Panciera, Stefano Piccolo, Giovanna Brusatin   +12 more
wiley   +1 more source

The Identification and Education of the Gifted Child in the Regular Classroom [PDF]

, 1953
It is the purpose of this study to prepare the way for a better understanding of the mentally gifted child and how his needs can best be met in the regular ...
Chapman, Charles M.
core   +1 more source

DMAP1 Deficiency Suppresses Lung Cancer Progression by Destabilizing Replication Fork and Activating IFN Signaling‐Mediated Anti‐tumor Immunity

Advanced Science, EarlyView.
Lung cancer remains the leading cause of cancer‐related death. We investigated the role of the epigenetic regulator DMAP1 in NSCLC and found that its loss induces replication stress and DNA damage. This in turn activates type I IFN signaling via the cGAS–STING pathway and transcriptional ISG de‐repression, enhancing anti‐tumor immune responses ...
Kan Huang, Xi Dai, Shuaihu Li, Yingxue Chen, Yaxin Yu, Lin Wang, Kun Liu, Shuhan Lyu, Chongyang Li, Yihua Sun, Fei Li   +10 more
wiley   +1 more source

Parenting ‘gifted and talented’ children in urban areas: Parents' voices [PDF]

, 2016
This is the author's accepted manuscript. The final published article is available from the link below. Copyright © 2014 by SAGE Publications.International evidence demonstrates the importance of engaging parents in the education of their ‘high-potential’
Allen G, Blunkett D, Callahan C, Casey R, DCSF (Department for Children, Schools and Families), DCSF (Department for Children, Schools and Families), Desforges C, DfEE (Department for Education and Employment), DfEE (Department for Education and Employment), Goodall J, Her Majesty’s Inspectorate, Her Majesty’s Inspectorate, Lampl P, Robinson A, Vygotsky L, Westmoreland H   +15 more
core   +1 more source

Nanoscale Spatial Organization of ARC High‐ and Low‐Order Assemblies at Excitatory Synapses

Advanced Science, EarlyView.
ARC (Activity‐Regulated Cytoskeleton‐Associated protein) mediates synaptic plasticity by forming nanoscale assemblies in neurons. Using super‐resolution microscopy and time‐resolved anisotropy with targeted tagging, the study reveals low‐order ARC assemblies at synapses colocalizing with AMPARs, semi‐circular structures at endocytic zones, and 60–80 nm
Martina Damenti, Giovanna Coceano, Mariline Mendes Silva, Jonatan Alvelid, Chiara Sgattoni, Andrea Volpato, Lea Rems, Luciano A. Masullo, Eduard M. Unterauer, Rafal Kowalewski, Lucie Delemotte, Erdinc Sezgin, Ralf Jungmann, Ilaria Testa   +13 more
wiley   +1 more source

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

Giftedness as a Factor in Constituting a Creative Person

Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen'
Purpose. The basis of the presented study is a philosophical and anthropological analysis of the problem of creativity in the modern educational space, which is complemented by information and digital reality underlying the changes in the values and ...
L. I. Tkachenko, A. A. Ilina
doaj   +1 more source

MENGENALI GIFTED PADA ANAK MELALUI PERKEMBANGAN BAHASA

Jurnal Edukasi Khatulistiwa: Pembelajaran Bahasa dan Sastra Indonesia, 2020
One language development of children who appear to be less than perfect is gifted or giftedness. This imperfect development received the attention of experts in the fields of language, health, and education, as well as other experts.
David Syasli
doaj   +1 more source

Abstracts of Theses on the Gifted Child Done between 1923 and 1957 at Boston University and Columbia University [PDF]

, 1958
Thesis (M.Ed.)--Boston ...
Gaffney, Theresa W., Ramsdell, Marian C., Silverman, David J.   +2 more
core   +1 more source

DNA Replication Errors Drive Genome‐Wide Small Inverted Triplication Dynamics

Advanced Science, EarlyView.
This study provides insight into the dynamic equilibrium mechanism of a novel structural variant, small inverted triplication (SIT), which is generated by misalignment of the 3’ flap generated under DNA replication stress with palindromic sequence. Alternatively, the end sequence may fold back on itself to form an inverted fragment.
Yi Lei, Yu Zhou, Haitao Sun, Hang Yuan, Xinyu Pei, Jessica D. Hess, Yao Yan, Zunsong Hu, Mian Zhou, Zhaohui Gu, Li Zheng, Xiwei Wu, Binghui Shen   +12 more
wiley   +1 more source