EXPRESSION OF A FUNCTIONAL CHIMERIC lg-MHC CLASS II PROTEIN [PDF]
, 1992 composed of the a- and ß-chains of the MHC class I1 I-E molecule fused to antibody V regions derived from anti-human CD4 mAb MT310. Expression vectors were constructed containing the functional, rearranged gene segments coding for the V region domains of
Becker, Andrea +8 more
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Vaccines, 2020 Leishmaniases are complex vector-borne diseases caused by intracellular parasites of the genus Leishmania. The visceral form of the disease affects both humans and canids in tropical, subtropical, and Mediterranean regions.
Maria Agallou +3 more
doaj +1 more source
Immunogenic evaluation of recombinant chimeric protein containing EspA- Stx2b- Intimin against E.coli O157 H7 [PDF]
مجله علمی دانشگاه علوم پزشکی کردستان, 2018 Background and Aim: Enterohemorrhagic Escherichia coli (EHEC) cause a wide spectrum of infections, such as diarrhea, hemorrhagic colitis and hemolytic–uremic syndrome.
Taheri M +4 more
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Characterization of structural and immunological properties of a fusion protein between flagellin from Salmonella and lumazine synthase from Brucella [PDF]
, 2017 Aiming to combine the flexibility of Brucella lumazine synthase (BLS) to adapt different protein domains in a decameric structure and the capacity of BLS and flagellin to enhance the immunogenicity of peptides that are linked to their structure, we ...
Berguer, Paula Mercedes +11 more
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Computational design of fusion proteins against ErbB2-amplified tumors inspired by ricin toxin
Frontiers in Molecular Biosciences, 2023 Although the anti-cancer activity of ricin is well-known, its non-specific targeting challenges the development of ricin-derived medicines. In the present study, novel potential ribosome-inactivating fusion proteins (RIPs) were computationally engineered
Yasser Ahmadi Moghaddam +3 more
doaj +1 more source
Different 3' end regions strongly influence the level of gene expression in plant cells [PDF]
, 1989 We have investigated the functional role of a 3' end region on the expression of a reporter gene in plant cells. In stably transformed plants, expression of the reporter gene without a plant gene 3' end is variable and depends on the fortuitous presence ...
Ingelbrecht, Ivan +4 more
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Rescue of a genotype 4 human hepatitis E virus from cloned cDNA and characterization of intergenotypic chimeric viruses in cultured human liver cells and in pigs [PDF]
, 2012 Hepatitis E virus (HEV) is an important but extremely understudied human pathogen. Genotypes 1 and 2 are restricted to humans, whereas genotypes 3 and 4 are zoonotic, infecting both humans and pigs.
Alicia R. Feagins +15 more
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In silico analysis of chimeric recombinant immunogen against three diarrhea causing bacteria [PDF]
Journal of Cell and Molecular Research, 2013 Shigella and Escherichia belong to the Enterobacteriaceae family which are the cause for most of the diarrheal cases in the world. Shigella can cause bacterial dysenteries and shigellosis.
Farzaneh Khaloiee +5 more
doaj +1 more source
Chimeric glutamate receptor subunits reveal the transmembrane domain is sufficient for NMDA receptor pore properties but some positive allosteric modulators require additional domains [PDF]
, 2016 NMDA receptors are ligand-gated ion channels that underlie transmission at excitatory synapses and play an important role in regulating synaptic strength and stability.
Huettner, Jmaes E +2 more
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FHL2 regulates hematopoietic stem cell functions under stress conditions. [PDF]
, 2015 FHL2, a member of the four and one half LIM domain protein family, is a critical transcriptional modulator. Here, we identify FHL2 as a critical regulator of hematopoietic stem cells (HSCs) that is essential for maintaining HSC self-renewal under ...
Chen, J +12 more
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