Results 81 to 90 of about 5,931 (188)
Emerging roles for integrated stress response signaling in homeostasis
The FEBS Journal, Volume 292, Issue 17, Page 4418-4445, September 2025.Integrated stress response (ISR), an evolutionarily conserved eukaryotic stress‐adaptive program in eukaryotes, has also been implicated in homeostatic functions. This review covers a broad body of literature and presents several homeostatic functions of ISR in the absence of stress: (a) developmental processes (morphogenesis, differentiation, aging), (
Shyama Nandakumar +2 more
wiley +1 more source
STAR ProtocolsSummary: Simultaneous high-throughput ATAC and RNA expression with sequencing (SHARE-seq) profiles transcriptomics and chromatin accessibility in the same cells at high throughput.
Haikuo Li, Benjamin D. Humphreys
doaj +1 more source
Dial M(RF) for myogenesis [PDF]
, 2013 The transcriptional regulatory network that controls the determination and differentiation of skeletal muscle cells in the embryo has at its core the four myogenic regulatory factors (MRFs) Myf5, MyoD, Mrf4 and MyoG.
Carvajal, Jaime J. +2 more
core +1 more source
The FASEB Journal, Volume 39, Issue 15, 15 August 2025.Simultaneous deletion of TBL1 and TBLR1 in brown adipocytes leads to reduced expression of PRDM16 target genes, associated with impaired adaptive thermogenesis and defective BAT remodeling during prolonged cold exposure. While TBLR1 loss alone has minimal effects, the double knockout disrupts cold‐induced energy expenditure and promotes BAT whitening ...
Sahika Cingir Köker +25 more
wiley +1 more source
Complex coordination of cell plasticity by a PGC-1α-controlled transcriptional network in skeletal muscle [PDF]
, 2015 Skeletal muscle cells exhibit an enormous plastic capacity in order to adapt to external stimuli. Even though our overall understanding of the molecular mechanisms that underlie phenotypic changes in skeletal muscle cells remains poor, several factors ...
Agrawal +52 more
core +4 more sources
A Multi-Layered Study on Harmonic Oscillations in Mammalian Genomics and Proteomics [PDF]
, 2019 Cellular, organ, and whole animal physiology show temporal variation predominantly featuring 24-h (circadian) periodicity. Time-course mRNA gene expression profiling in mouse liver showed two subsets of genes oscillating at the second (12-h) and third (8-
Biagini, Tommaso +11 more
core +1 more source
Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]
, 2020 Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert +58 more
core +3 more sources
Heat*seq: compare your NGS experiment with RNAseq/ ChIPseq/ CAGE public datasets
, 2016 With the establishment of better protocols and decreasing costs, high-throughput sequencing experiments such as RNA-seq or ChIP-seq are now accessible even to small experimental laboratories. However, comparing one or few experiments generated by an individual lab to the vast amount of relevant data available in public domain might be hindered due to ...
Devailly, Guillaume +2 more
openaire +1 more source
Alzheimer's &Dementia, Volume 21, Issue 8, August 2025.Abstract The heterogeneity of Alzheimer's disease (AD) is multi‐dimensional, encompassing clinical features such as neuropsychiatric symptoms (NPS), rate of progression, age of onset, comorbidities, and neuropathological features such as co‐pathologies, and represents the diverse outcomes of manifold genetic and environmental risk determinants.
E. Keats Shwab +21 more
wiley +1 more source
Molecular MetabolismObjective: All forms of diabetes result from insufficient functional β-cell mass. Thus, achieving the therapeutic goal of expanding β-cell mass requires a better mechanistic understanding of how β-cells proliferate.
Liora S. Katz +10 more
doaj +1 more source