Results 61 to 70 of about 5,931 (188)
A direct fate exclusion mechanism by Sonic Hedgehog-regulated transcriptional repressors [PDF]
, 2015 Sonic hedgehog (Shh) signaling patterns the vertebrate spinal cord by activating a group of transcriptional repressors in distinct neural progenitors of somatic motor neuron and interneuron subtypes. To identify the action of this network, we performed a
Bulyk, M.L. +7 more
core +2 more sources
Functional Ecology, Volume 39, Issue 11, Page 3050-3060, November 2025.Read the free Plain Language Summary for this article on the Journal blog. Abstract Interactions between developing embryos and a multitude of environmental factors (e.g. climate, nutrition, social cues, stress and anthropogenic contaminants) underlie adaptive and non‐adaptive developmental plasticity and carry broad implications across ecological ...
Benjamin B. Parrott, Samantha L. Bock
wiley +1 more source
Normalization of ChIP-seq data with control
BMC Bioinformatics, 2012 Background ChIP-seq has become an important tool for identifying genome-wide protein-DNA interactions, including transcription factor binding and histone modifications. In ChIP-seq experiments, ChIP samples are usually coupled with their matching control
Liang Kun, Keleş Sündüz
doaj +1 more source
Theoretical characterisation of strand cross-correlation in ChIP-seq
BMC Bioinformatics, 2020 Background Strand cross-correlation profiles are used for both peak calling pre-analysis and quality control (QC) in chromatin immunoprecipitation followed by sequencing (ChIP-seq) analysis.
Hayato Anzawa +2 more
doaj +1 more source
Meis2 Is Required for Inner Ear Formation and Proper Morphogenesis of the Cochlea
Frontiers in Cell and Developmental Biology, 2021 Meis genes have been shown to control essential processes during development of the central and peripheral nervous system. Here we have explored the roles of the Meis2 gene during vertebrate inner ear induction and the formation of the cochlea.
María Beatriz Durán Alonso +10 more
doaj +1 more source
Loci specific epigenetic drug sensitivity. [PDF]
, 2020 Therapeutic targeting of epigenetic modulators offers a novel approach to the treatment of multiple diseases. The cellular consequences of chemical compounds that target epigenetic regulators (epi-drugs) are complex.
Pilko, Anna +2 more
core +1 more source
Common variants at theCHEK2gene locus and risk of epithelial ovarian cancer [PDF]
, 2015 Genome-wide association studies have identified 20 genomic regions associated with risk of epithelial ovarian cancer (EOC), but many additional risk variants may exist.
Agnieszka Budzilowska +157 more
core +2 more sources
Advanced Science, Volume 12, Issue 39, October 20, 2025.Targeting eRNAs from TNFα‐associated super‐enhancers with ASOs effectively reduces TNFα expression and inflammatory responses in both mouse models and patient‐derived immune cells. The conserved nature of these regulatory regions between species highlights the potential of eRNA‐targeted approaches as a therapeutic strategy for chronic inflammatory ...
Minjeong Cho +12 more
wiley +1 more source
Evaluation of algorithm performance in ChIP-seq peak detection. [PDF]
PLoS ONE, 2010 Next-generation DNA sequencing coupled with chromatin immunoprecipitation (ChIP-seq) is revolutionizing our ability to interrogate whole genome protein-DNA interactions.
Elizabeth G Wilbanks, Marc T Facciotti
doaj +1 more source
Circr, a Computational Tool to Identify miRNA:circRNA Associations
Frontiers in Bioinformatics, 2022 Circular RNAs (circRNAs) are known to act as important regulators of the microRNA (miRNA) activity. Yet, computational resources to identify miRNA:circRNA interactions are mostly limited to already annotated circRNAs or affected by high rates of false ...
Martina Dori +3 more
doaj +1 more source