Results 41 to 50 of about 3,719 (149)

Aging‐Related Muscle Bmal1 Decline Contributes to Bone Loss in Mice via Enhancing IL‐1α–Mediated Osteoclastogenesis

Aging Cell, Volume 25, Issue 6, June 2026.
Aging‐related decline of muscle Bmal1 drives bone loss in mice by disrupting Hmox1 and increasing IL‐1α, which promotes osteoclast activity. Time‐restricted feeding reestablishes diurnal Hmox1 expression, reduces IL‐1α, and alleviates osteoporosis, offering a potential therapeutic strategy. ABSTRACT Osteoporosis, a common metabolic bone disorder linked
Kai Huang, Jun Qian, Yike Wang, Feng Zhang, Youjia Xu, Qiaocheng Zhai   +5 more
wiley   +1 more source

Normalization of ChIP-seq data with control

BMC Bioinformatics, 2012
Background ChIP-seq has become an important tool for identifying genome-wide protein-DNA interactions, including transcription factor binding and histone modifications. In ChIP-seq experiments, ChIP samples are usually coupled with their matching control
Liang Kun, Keleş Sündüz
doaj   +1 more source

Heat*seq: compare your NGS experiment with RNAseq/ ChIPseq/ CAGE public datasets

, 2016
With the establishment of better protocols and decreasing costs, high-throughput sequencing experiments such as RNA-seq or ChIP-seq are now accessible even to small experimental laboratories. However, comparing one or few experiments generated by an individual lab to the vast amount of relevant data available in public domain might be hindered due to ...
Devailly, Guillaume, Mantsoki, Anna, Anagha Joshi   +2 more
openaire   +1 more source

BCR::ABL1‐Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B‐ALL Cells to Enhancer‐Targeting Drugs

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Ng et al. show that the BCR::ABL1 kinase that drives the lymphoid leukemia Ph+B‐ALL modulates enhancer function by coopting signaling‐inducible transcription factors such as MYC, STAT5, and ETV5. BCR::ABL1 thereby promotes the transcriptional program driving and defining this leukemia and renders Ph+B‐ALL cells hypersensitive to enhancer‐inhibiting ...
Han Leng Ng, Trudy Lee Glaser, Jintao Zhu, Mark E. Robinson, Kadriye N. Cosgun, Valeriya Malysheva, Ozgen Deniz, Nicholas T. Crump, Kaiyue Helian, Andrew J. Innes, Richard Burt, Li Sun, George John, Haibin Zhou, Atsunori Kaneshige, Longchuan Bai, Shaomeng Wang, Mikhail Spivakov, Markus Müschen, Niklas Feldhahn   +19 more
wiley   +1 more source

ChIPulate: A comprehensive ChIP-seq simulation pipeline.

PLoS Computational Biology, 2019
ChIP-seq (Chromatin Immunoprecipitation followed by sequencing) is a high-throughput technique to identify genomic regions that are bound in vivo by a particular protein, e.g., a transcription factor (TF).
Vishaka Datta, Sridhar Hannenhalli, Rahul Siddharthan   +2 more
doaj   +1 more source

Evaluation of algorithm performance in ChIP-seq peak detection. [PDF]

PLoS ONE, 2010
Next-generation DNA sequencing coupled with chromatin immunoprecipitation (ChIP-seq) is revolutionizing our ability to interrogate whole genome protein-DNA interactions.
Elizabeth G Wilbanks, Marc T Facciotti
doaj   +1 more source

Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses

Experimental Physiology, Volume 111, Issue 3, Page 1365-1386, 1 March 2026.
Abstract Uteroplacental insufficiency impairs kidney development and programs male‐onset cardiorenal disease, which can be transmitted to subsequent generations. Maternal lifestyle factors can independently influence fetal kidney development, highlighting that the lifestyle of growth‐restricted females can have further influence on F2 kidney ...
Jessica F. Briffa, Sogand Gravina, Viktoria F. Richter, Dayana Mahizir, Kristina Anevska, Yeukai T. M. Mangwiro, James S. M. Cuffe, Fadi Charchar, Glenn D. Wadley, Deanne H. Hryciw, Karen M. Moritz, Mary E. Wlodek   +11 more
wiley   +1 more source

Machine learning reveals STAT motifs as predictors for GR-mediated gene repression

Computational and Structural Biotechnology Journal, 2023
Glucocorticoids are potent immunosuppressive drugs, but long-term treatment leads to severe side-effects. While there is a commonly accepted model for GR-mediated gene activation, the mechanism behind repression remains elusive.
Barbara Höllbacher, Benjamin Strickland, Franziska Greulich, N. Henriette Uhlenhaut, Matthias Heinig   +4 more
doaj   +1 more source

Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential

Developmental Neurobiology, Volume 86, Issue 1, January 2026.
ABSTRACT Adult patterns of behavior can often be explained by developmental experiences. In some cases, developmental experience can have permanent influence on brain and behavior only during specific ages; these phases are called critical or sensitive periods. Epigenetic mechanisms can regulate both maturational and experiential processes in the brain
Grant W. Kunzelman, Alice Batistuzzo, Sarah E. London   +2 more
wiley   +1 more source

BayesPeak: Bayesian analysis of ChIP-seq data

BMC Bioinformatics, 2009
Background High-throughput sequencing technology has become popular and widely used to study protein and DNA interactions. Chromatin immunoprecipitation, followed by sequencing of the resulting samples, produces large amounts of data that can be used to ...
Stark Rory, Spyrou Christiana, Lynch Andy G, Tavaré Simon   +3 more
doaj   +1 more source