Results 51 to 60 of about 5,931 (188)

RNA Binding to CBP Stimulates Histone Acetylation and Transcription [PDF]

, 2017
CBP/p300 are transcription co-activators whose binding is a signature of enhancers, cis-regulatory elements that control patterns of gene expression in multicellular organisms. Active enhancers produce bi-directional enhancer RNAs (eRNAs) and display CBP/
Bailey, Barlev, Bedford, Beltran, Berndsen, Bezzi, Bonasio, Bowers, Castello, Cifuentes-Rojas, Corcoran, Creyghton, Daniel A. Bose, Danny Reinberg, Davidovich, De Santa, Delvecchio, Di Ruscio, Friedersdorf, Greg Donahue, Gupta, Hafner, Hah, He, Heinz, Hendrickson, Henry, Hilton, Hsieh, Huang, Huppertz, Jin, Kagey, Kaikkonen, Kaneko, Kaneko, Kaneko, Kasper, Kim, Kim, Lai, Lam, Lam, Langmead, Li, Li, Lienert, Liu, Lowary, Luger, Martin, Matys, May, Melo, Meng, Mousavi, Peterson, Pnueli, Postepska-Igielska, Quinlan, Rada-Iglesias, Ramin Shiekhattar, Roberto Bonasio, Schaukowitch, Schröder, Shelley L. Berger, Shen, Stasevich, Sun, Tanaka, Thompson, Thompson, Tie, Wang, Wang, Wang, Wang, Wang, Wongtrakoongate, Yang, Yue, Zhang, Ørom   +82 more
core   +1 more source

Proteotoxic stress reprograms the chromatin landscape of SUMO modification [PDF]

, 2015
The small ubiquitin-like modifier 2 (SUMO-2) is required for survival when cells are exposed to treatments that induce proteotoxic stress by causing the accumulation of misfolded proteins.
Anne Seifert, Geoffrey J. Barton, Pietà Schofield, Ronald T. Hay, Tanaka   +4 more
core   +3 more sources

Genome-Wide Mapping of in Vivo Protein-DNA Interactions [PDF]

, 2007
In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To map these protein-DNA interactions comprehensively across entire mammalian genomes, we developed a large-scale chromatin ...
Johnson, David S., Mortazavi, Ali, Myers, Richard M., Wold, Barbara   +3 more
core   +1 more source

Impact of diet and exercise in growth restricted female rats on nephron endowment in male fetuses

Experimental Physiology, Volume 111, Issue 3, Page 1365-1386, 1 March 2026.
Abstract Uteroplacental insufficiency impairs kidney development and programs male‐onset cardiorenal disease, which can be transmitted to subsequent generations. Maternal lifestyle factors can independently influence fetal kidney development, highlighting that the lifestyle of growth‐restricted females can have further influence on F2 kidney ...
Jessica F. Briffa, Sogand Gravina, Viktoria F. Richter, Dayana Mahizir, Kristina Anevska, Yeukai T. M. Mangwiro, James S. M. Cuffe, Fadi Charchar, Glenn D. Wadley, Deanne H. Hryciw, Karen M. Moritz, Mary E. Wlodek   +11 more
wiley   +1 more source

GenoMetric Query Language: A novel approach to large-scale genomic data management [PDF]

, 2015
Motivation: Improvement of sequencing technologies and data processing pipelines is rapidly providing sequencing data, with associated high-level features, of many individual genomes in multiple biological and clinical conditions.
Ceri S, Jalili V, Kaitoua A, Masseroli M, Muller H, Palluzzi F, Pinoli P, Venco F   +7 more
core   +1 more source

Chromatin Profiling Reveals Distinct Male and Female Trajectories for Developmental Learning Potential

Developmental Neurobiology, Volume 86, Issue 1, January 2026.
ABSTRACT Adult patterns of behavior can often be explained by developmental experiences. In some cases, developmental experience can have permanent influence on brain and behavior only during specific ages; these phases are called critical or sensitive periods. Epigenetic mechanisms can regulate both maturational and experiential processes in the brain
Grant W. Kunzelman, Alice Batistuzzo, Sarah E. London   +2 more
wiley   +1 more source

Novel and unscrutinized immune entities of the zebrafish gut

FEBS Letters, Volume 599, Issue 23, Page 3444-3455, December 2025.
Understudied cells of the zebrafish immune system include bona fide immune cells and epithelial (‐derived) cells with immune functions. Research focusing on zebrafish cells which demonstrate similarities to mammalian immune cell counterparts may help us understand the pathologies in which they are implicated. Currently available and advanced tools make
Audrey Inge Schytz Andersen‐Civil, Marine Mantel, Julia Soh, Serge Mostowy, Sylvia Brugman, Gilles Claude Vanwalleghem   +5 more
wiley   +1 more source

A combinatorial strategy of alternative promoter use during differentiation of a heterocystous cyanobacterium [PDF]

, 2017
Heterocystous cyanobacteria such as Nostoc sp. are filamentous photosynthetic organisms that, in response to nitrogen deficiency, undergo a differentiation process transforming certain, semi-regularly spaced cells into heterocysts, devoted to nitrogen ...
Brenes Álvarez, Manuel, Muro Pastor, Alicia María, Vioque Peña, Agustín   +2 more
core   +1 more source

Epigenetic Regulation of G6PD Drives Metabolic Reprogramming in Intrahepatic Cholangiocarcinoma

Cancer Science, Volume 116, Issue 12, Page 3352-3366, December 2025.
This study reveals that tumor‐specific enhancers drive G6PD overexpression in intrahepatic cholangiocarcinoma (ICC), thereby enhancing pentose phosphate pathway activity, maintaining redox homeostasis, and promoting cell proliferation and chemoresistance.
Yusuke Nakano, Miwa Tanaka, Takeharu Sakamoto, Masahiro Hashimoto, Taro Tobo, Hideyuki Saito, Tadashi Abe, Tomohiko Ikehara, Takashi Ofuchi, Koto Kawata, Takaaki Masuda, Takayuki Ogino, Mamoru Uemura, Hidetoshi Eguchi, Yuichiro Doki, Koshi Mimori   +15 more
wiley   +1 more source

Purification of immune-active macrophage super enhancers by chemical cross-linked chromatin immune precipitation

STAR Protocols, 2023
Summary: Isolation of extraordinarily long-length super-enhancers (SEs) using typical chromatin immune precipitation (ChIP) techniques can lead to DNA breakage due to uncontrolled cross-linking.
Sonali Das, Sohitri Mukherjee, Nahid Ali
doaj   +1 more source