Results 21 to 30 of about 10,800 (238)
Enantioselective Synthesis of Piperidines through the Formation of Chiral Mixed Phosphoric Acid Acetals: Experimental and Theoretical Studies [PDF]
, 2014 An enantioselective intramolecular chiral phosphoric acid‐catalyzed cyclization of unsaturated acetals has been utilized for the synthesis of functionalized chiral piperidines.
Nagorny, Pavel +3 more
core +3 more sources
Recent applications of chiral phosphoric acids in palladium catalysis [PDF]
Organic & Biomolecular Chemistry, 2020 A variety of catalytic asymmetric reactions have been realized during the past decade through the combined action of palladium and chiral phosphoric acids (CPAs). This review surveys key examples and examines the underlying mechanisms of stereoinduction.
Van T. Tran +3 more
openaire +2 more sources
Nature Communications, 2020 Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α ...
Jiuwei Che +4 more
doaj +1 more source
Nature Communications, 2023 As the complexity of organic molecules utilized by mankind increases, the phenomenon of atropisomerism is more frequently encountered. While a variety of well-established methods enable the control of a stereogenic center, a catalytic method for ...
Ahreum Kim +4 more
doaj +1 more source
Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
Nature Communications, 2021 Synthesizing complex structures of high enantiomeric excess from racemic feedstock is an enduring challenge. Here, the authors couple racemic secondary alcohols with pyrroles to form enantioenriched 2-substituted heteroarenes, via a borrowing hydrogen ...
Yongbing Liu +4 more
doaj +1 more source
Organocatalytic Asymmetric [2 + 4] Cycloadditions of 3-Vinylindoles with ortho-Quinone Methides
Molecules, 2021 Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural ...
Si-Jia Liu +6 more
doaj +1 more source
Organocatalytic synthesis of axially chiral atropisomers [PDF]
, 2017 This review summarises the recent progress made in the organocatalytic synthesis of atropisomeric compounds. Methodologies based on dynamic kinetic resolution and direct access to BINOL-like biaryls are described.
Renzi, P.
core +1 more source
Nature Communications, 2021 Acyclic quaternary stereocenters are widely present in a series of biologically active natural products and pharmaceuticals. Here the authors show an efficient chiral phosphoric acid catalyzed direct asymmetric addition of α-alkynyl acyclic ketones with ...
Jiawen Wang, Faqian He, Xiaoyu Yang
doaj +1 more source
N-Triflylphosphorimidoyl Trichloride: A Versatile Reagent for the Synthesis of Strong Chiral Brønsted Acids [PDF]
, 2017 A series of strong Brønsted acids has been synthesized in high yields using N-triflylphosphorimidoyl trichloride as reagent.
Kaib, P., Lee, S., List, B.
core +2 more sources
Rational design of a (S)-selective-transaminase for asymmetric synthesis of (1S)-1-(1,1′-biphenyl-2-yl)ethanamine [PDF]
, 2016 Amine transaminases offer an environmentally sustainable synthesis route for the production of pure chiral amines. However, their catalytic efficiency toward bulky ketone substrates is greatly limited by steric hindrance and therefore presents a great ...
Allen, Christopher C.R. +12 more
core +3 more sources