Results 21 to 30 of about 2,722 (150)
Nature Communications, 2021 Although the hetero-Diels–Alder reaction is a staple of organic chemistry, catalytic asymmetric versions of the inverse-electron demand variant often require specially engineered substrates for the reaction to work. Here the authors cyclize non-activated
Min Jin +10 more
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Nature Communications, 2020 Strategies for enantioselective α-aminomethylation of carbonyl compounds rely on the chiral activation of stable ketones substrate. Here, the authors report a rhodium/chiral phosphoric acid cooperative catalysis for the three-component reaction of α ...
Jiuwei Che +4 more
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Nature Communications, 2023 As the complexity of organic molecules utilized by mankind increases, the phenomenon of atropisomerism is more frequently encountered. While a variety of well-established methods enable the control of a stereogenic center, a catalytic method for ...
Ahreum Kim +4 more
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Redox-enabled direct stereoconvergent heteroarylation of simple alcohols
Nature Communications, 2021 Synthesizing complex structures of high enantiomeric excess from racemic feedstock is an enduring challenge. Here, the authors couple racemic secondary alcohols with pyrroles to form enantioenriched 2-substituted heteroarenes, via a borrowing hydrogen ...
Yongbing Liu +4 more
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Nature Communications, 2021 Acyclic quaternary stereocenters are widely present in a series of biologically active natural products and pharmaceuticals. Here the authors show an efficient chiral phosphoric acid catalyzed direct asymmetric addition of α-alkynyl acyclic ketones with ...
Jiawen Wang, Faqian He, Xiaoyu Yang
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Organocatalytic Asymmetric [2 + 4] Cycloadditions of 3-Vinylindoles with ortho-Quinone Methides
Molecules, 2021 Catalytic asymmetric [2 + 4] cycloadditions of 3-vinylindoles with ortho-quinone methides and their precursors were carried out in the presence of chiral phosphoric acid to afford a series of indole-containing chroman derivatives with structural ...
Si-Jia Liu +6 more
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Phosphoric Acids as Amplifiers of Molecular Chirality in Liquid Crystalline Media [PDF]
Organic Letters, 2006 [structure: see text] A new system for the double amplification of the molecular chirality of simple chiral amines in achiral liquid crystalline media is described. It involves a conformationally flexible phosphoric acid based receptor that by binding to chiral amines induces chirality in the liquid crystalline matrix.
Eelkema, R, Feringa, BL
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Organocatalytic atroposelective construction of axially chiral arylquinones
Nature Communications, 2019 Axially chiral compounds have widespread use in asymmetric catalysis. Here, the authors disclose a highly enantioselective synthesis of axially chiral o-naphthoquinones by chiral phosphoric acid catalysis and central-to-axial chirality conversion.
Shuai Zhu +8 more
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Brønsted acid-catalysed enantioselective construction of axially chiral arylquinazolinones
Nature Communications, 2017 Axially chiral arylquinazolinones are structural motifs in several natural products and can also act as chiral ligands. Here, the authors show a chiral phosphoric acid-catalysed strategy to access enantiomerically pure arylquinazolinones by efficient ...
Yong-Bin Wang +3 more
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Chiral Phosphoric Acid Catalysis: The Terada Model Revisited
The Journal of Organic Chemistry, 2021 Since Akiyama and Terada independently reported the introduction of chiral phosphoric acids (CPAs) as effective catalysts for Mannich-type reactions in 2004, the field of CPA catalysis has grown immensely. Terada reported in 2008 the first example of the activation of aldehydes by a CPA.
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