Results 181 to 190 of about 139,121 (234)

Tectorigenin alleviates intrahepatic cholestasis by inhibiting hepatic inflammation and bile accumulation via activation of PPARγ

British Journal of Pharmacology, 2021
Increasing evidence suggests that human cholestasis is closely associated with the accumulation and activation of hepatic macrophages. Research indicates that activation of PPARγ exerts liver protective effects in cholestatic liver disease (CLD ...
Jiaqing Xiang, Guangyan Yang, Chuan-Rui Ma, Lingling Wei, Han Wu, Wei Zhang, X. Tao, Ling-yun Jiang, Zhen Liang, Lin Kang, Shu Yang   +10 more
semanticscholar   +1 more source

Intrahepatic Cholestasis of Pregnancy

Clinical Obstetrics & Gynecology, 2020
Intrahepatic cholestasis of pregnancy is a common disorder of pregnancy manifested by pruritus and elevated bile acids. The etiology of cholestasis is poorly understood and management is difficult due to the paucity of data regarding its diagnosis, treatment, and related adverse outcomes.
Devin D, Smith, Kara M, Rood
openaire   +2 more sources

Intrahepatic Cholestasis in Childhood

New England Journal of Medicine, 1976
The apparent well-being of some children who as neonates were believed to have obstructive jaundice prompted us to study the clinical course, histologic features and possible etiologic factors in 17 children with cholestasis in the neonatal period. During a follow-up period of five months to 22 years, all had signs of chronic cholestasis, but only four
J, Heathcote, K P, Deodhar, P J, Scheuer, S, Sherlock   +3 more
openaire   +2 more sources

Intrahepatic cholestasis induced by α-naphthylisothiocyanate can cause gut-liver axis disorders.

Environmental Toxicology and Pharmacology, 2021
Clinical studies have shown that Intrahepatic cholestasis is closely related to intestinal injury. The gut-liver axis theory suggests that the intestine and liver are closely related, and that bile acids are important mediators linking the intestine and ...
Zhengyuan Chen, Yuhuan Wu, Bixia Wang, Jiamin Fang, Changlian Gan, Chuan-Lan Sang, Dun Zhu, Tajie Luosang, Qing Wang, Dawa Zeren, Tian-Qin Xiong   +10 more
semanticscholar   +1 more source

Guideline No. 452: Diagnosis and Management of Intrahepatic Cholestasis of Pregnancy.

Journal of Obstetrics and Gynaecology Canada
OBJECTIVE To summarize the current evidence and to make recommendations for the diagnosis and management of intrahepatic cholestasis of pregnancy. TARGET POPULATION Pregnant people with intrahepatic cholestasis of pregnancy.
Sebastian R Hobson, Elissa R Cohen, Shital Gandhi, Venu Jain, Kirsten M. Niles, M. Roy-Lacroix, B. Wo   +6 more
semanticscholar   +1 more source

Intrahepatic Cholestasis of Pregnancy

Nursing for Women's Health, 2015
Itching is commonly reported by pregnant women and may be due to physiologic changes of pregnancy or could indicate a more serious health concern. Intrahepatic cholestasis of pregnancy, while classified as a pregnancy dermatosis, is actually a liver disease of pregnancy associated with significant fetal mortality and morbidity, as well as lifelong ...
Cathi, Phillips, Margaret, Boyd
openaire   +2 more sources

Intrahepatic cholestasis of pregnancy

Clinics in Liver Disease, 2004
Patients with ICP should be considered to have a high-risk pregnancy. Once the diagnosis of ICP is suspected, usually because of generalized pruritus, it should be confirmed by liver function tests, and other causes of cholestasis should be ruled out.
Caroline A, Riely, Yannik, Bacq
openaire   +2 more sources

Intrahepatic cholestasis of pregnancy

Current Treatment Options in Gastroenterology, 2003
Intrahepatic cholestasis of pregnancy (or obstetric cholestasis) is a liver disorder that occurs in late pregnancy. Despite the potential adverse maternal and fetal/neonatal outcomes, cholestasis of pregnancy is often neglected and treated expectantly.
Frank, Lammert, Hanns-Ulrich, Marschall, Siegfried, Matern   +2 more
openaire   +2 more sources

Intrahepatic cholestasis of pregnancy

Seminars in Perinatology, 1998
Intrahepatic cholestasis of pregnancy (ICP) is a disease of the third trimester of pregnancy involving pruritus and elevated bile acid levels. Its pathogenesis likely involves a genetic hypersensitivity to estrogen. Once thought to be benign for both mother and fetus, ICP has been associated with increased rates of fetal morbidity and mortality and an ...
openaire   +2 more sources

BENIGN RECURRENT INTRAHEPATIC CHOLESTASIS

Clinics in Liver Disease, 1999
Benign recurrent intrahepatic cholestasis is a rare autosomal recessive disorder characterized by repeated episodes of intense pruritus and jaundice. Each attack lasts from several weeks to months before resolving spontaneously. Patients are completely asymptomatic for months to years between symptomatic periods.
Velimir A, Luketic, Mitchell L, Shiffman
openaire   +3 more sources