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Bailliere's Best Practice and Research in Clinical Gastroenterology, 2010
Progressive familial intrahepatic cholestasis (PFIC) type 1, 2 and 3 are due to mutations in ATP8B1, ABCB11 and ABCB4, respectively. Each of these genes encodes a hepatocanalicular transporter, which is essential for the proper formation of bile. Mutations in ABCB4 can result in progressive cholestatic disease, while mutations in ATP8B1 and ABCB11 can ...
Saskia W C Van Mil
exaly +4 more sources
Progressive familial intrahepatic cholestasis (PFIC) type 1, 2 and 3 are due to mutations in ATP8B1, ABCB11 and ABCB4, respectively. Each of these genes encodes a hepatocanalicular transporter, which is essential for the proper formation of bile. Mutations in ABCB4 can result in progressive cholestatic disease, while mutations in ATP8B1 and ABCB11 can ...
Saskia W C Van Mil
exaly +4 more sources
Intrahepatic cholestasis of pregnancy
Česká gynekologieObjective: The aim of this work is to summarize current scientific information focusing on the diagnosis, management, and treatment of intrahepatic cholestasis in pregnancy according to available literature. Methodology: Literature sources were searched using the Web of Science, Scopus, and PubMed/Medline databases.
Luděk, Kostka +2 more
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Intrahepatic Cholestasis of Pregnancy
Clinical Obstetrics & Gynecology, 2020Intrahepatic cholestasis of pregnancy is a common disorder of pregnancy manifested by pruritus and elevated bile acids. The etiology of cholestasis is poorly understood and management is difficult due to the paucity of data regarding its diagnosis, treatment, and related adverse outcomes.
Devin D, Smith, Kara M, Rood
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Intrahepatic Cholestasis in Childhood
New England Journal of Medicine, 1976The apparent well-being of some children who as neonates were believed to have obstructive jaundice prompted us to study the clinical course, histologic features and possible etiologic factors in 17 children with cholestasis in the neonatal period. During a follow-up period of five months to 22 years, all had signs of chronic cholestasis, but only four
J, Heathcote +3 more
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Intrahepatic Cholestasis of Pregnancy
Nursing for Women's Health, 2015Itching is commonly reported by pregnant women and may be due to physiologic changes of pregnancy or could indicate a more serious health concern. Intrahepatic cholestasis of pregnancy, while classified as a pregnancy dermatosis, is actually a liver disease of pregnancy associated with significant fetal mortality and morbidity, as well as lifelong ...
Cathi, Phillips, Margaret, Boyd
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Intrahepatic cholestasis of pregnancy
Current Treatment Options in Gastroenterology, 2003Intrahepatic cholestasis of pregnancy (or obstetric cholestasis) is a liver disorder that occurs in late pregnancy. Despite the potential adverse maternal and fetal/neonatal outcomes, cholestasis of pregnancy is often neglected and treated expectantly.
Frank, Lammert +2 more
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Intrahepatic cholestasis of pregnancy
Clinics in Liver Disease, 2004Patients with ICP should be considered to have a high-risk pregnancy. Once the diagnosis of ICP is suspected, usually because of generalized pruritus, it should be confirmed by liver function tests, and other causes of cholestasis should be ruled out.
Caroline A, Riely, Yannik, Bacq
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