Results 1 to 10 of about 960,807 (326)

Increased Platelet-derived Microparticles Counts is Correlated with Elevated Blood LDL Cholesterol in Acute Myocardial Infarction

Indonesian Biomedical Journal, 2022
BACKGROUND: Platelet-derived microparticles (PDMPs) and low-density lipoprotein (LDL) cholesterol are contributing factors to acute myocardial infarction (AMI).
Kelvin Supriami, Ira Puspitawati, Dyah Samti Mayasari, Anggoro Budi Hartopo   +3 more
doaj   +1 more source

Dyslipidemia and 10-year diabetes incidence in Japanese people: Population-based Panasonic cohort study 9

Frontiers in Endocrinology, 2022
Low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and LDL/HDL ratio have been associated with new-onset diabetes; however, their cut-off levels have not been determined.
Genki Kobayashi, Hiroshi Okada, Hiroshi Okada, Masahide Hamaguchi, Kazushiro Kurogi, Hiroaki Murata, Masato Ito, Michiaki Fukui   +7 more
doaj   +1 more source

Cardiovascular mortality after intensive LDL-Cholesterol lowering: Does baseline LDL-Cholesterol really matter?

American Journal of Preventive Cardiology, 2020
It remains controversial whether reductions in cardiovascular mortality after intensive lowering of low density lipoprotein cholesterol (LDL-C) depend on baseline LDL-C levels.
Safi U. Khan, Erin D. Michos
doaj   +1 more source

Remnant cholesterol predicts cardiovascular disease beyond LDL and ApoB: a primary prevention study.

European Heart Journal, 2021
AIMS Emerging evidence suggests that remnant cholesterol (RC) promotes atherosclerotic cardiovascular disease (ASCVD). We aimed to estimate RC-related risk beyond low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB) in patients without
Renato Quispe, S. Martin, E. Michos, Isha Lamba, R. Blumenthal, Anum Saeed, J. Lima, R. Puri, Sarah O. Nomura, M. Tsai, J. Wilkins, C. Ballantyne, S. Nicholls, S. Jones, M. Elshazly   +14 more
semanticscholar   +1 more source

Mathematical modelling of the most effective goal of cholesterol-lowering treatment in primary prevention

BMJ Open, 2022
Objective To compare quantitatively different recommended goals for cholesterol-lowering treatment in the primary prevention of atherosclerotic cardiovascular disease (ASCVD).Design Outcomes at pretreatment low-density lipoprotein (LDL) cholesterol ...
Handrean Soran, Safwaan Adam, Paul Durrington, Zohaib Iqbal   +3 more
doaj   +1 more source

In vivo adenine base editing of PCSK9 in macaques reduces LDL cholesterol levels

Nature Biotechnology, 2021
Most known pathogenic point mutations in humans are C•G to T•A substitutions, which can be directly repaired by adenine base editors (ABEs). In this study, we investigated the efficacy and safety of ABEs in the livers of mice and cynomolgus macaques for ...
Tanja Rothgangl, Melissa K Dennis, Paulo J. C. Lin, Rurika Oka, D. Witzigmann, L. Villiger, W. Qi, M. Hrůzová, Lucas Kissling, Daniela Lenggenhager, Costanza Borrelli, S. Egli, Nina Frey, Noëlle Bakker, John A. Walker, A. Kadina, D. Victorov, Martin Pacesa, Susanne Kreutzer, Zacharias Kontarakis, A. Moor, M. Jinek, D. Weissman, M. Stoffel, R. van Boxtel, K. Holden, N. Pardi, B. Thöny, J. Häberle, Ying K. Tam, S. Semple, Gerald Schwank   +31 more
semanticscholar   +1 more source

Small Dense Low‐Density Lipoprotein Cholesterol Is the Most Atherogenic Lipoprotein Parameter in the Prospective Framingham Offspring Study

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2021
Background Elevated plasma levels of direct low‐density lipoprotein cholesterol (LDL‐C), small dense LDL‐C (sdLDL‐C), low‐density lipoprotein (LDL) triglycerides, triglycerides, triglyceride‐rich lipoprotein cholesterol, remnant lipoprotein particle ...
Hiroaki Ikezaki, Elise Lim, L. Adrienne Cupples, Ching‐Ti Liu, Bela F. Asztalos, Ernst J. Schaefer   +5 more
doaj   +1 more source

Liver Transplantation to Provide Low-Density-Lipoprotein Receptors and Lower Plasma Cholesterol in a Child with Homozygous Familial Hypercholesterolemia [PDF]

, 1984
A six-year-old girl with severe hypercholesterolemia and atherosclerosis had two defective genes at the low-density-lipoprotein (LDL) receptor locus, as determined by biochemical studies of cultured fibroblasts.
Cummings, David W. Bilheimer, Goldstein, Joseph L. Goldstein, Michael S. Brown, Pittman, Schneider, Schneider, Scott M. Grundy, Thomas E. Starzl   +9 more
core   +1 more source

Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170 000 participants in 26 randomised trials [PDF]

, 2010
Background: Lowering of LDL cholesterol with standard statin regimens reduces the risk of occlusive vascular events in a wide range of individuals. We aimed to assess the safety and efficacy of more intensive lowering of LDL cholesterol with statin ...
Alsheikh-Ali, Ara, Armitage, Athyros, Ben-Yehuda, Cannon, Cannon, Chen, Colhoun, Davidson, Davidson, de Lemos, Downs, Fellstrom, Goldstein, Grundy, Holdaas, Iso, Kjekshus, Knopp, Koren, LaRosa, Nakamura, Pedersen, Pedersen, Ridker, Ridker, Sacks, Serruys, Sever, Shepherd, Shepherd, Stamler, Wanner   +33 more
core   +2 more sources

Besnoitia besnoiti infection alters both endogenous cholesterol de novo synthesis and exogenous LDL uptake in host endothelial cells [PDF]

, 2008
Besnoitia besnoiti, an apicomplexan parasite of cattle being considered as emergent in Europe, replicates fast in host endothelial cells during acute infection and is in considerable need for energy, lipids and other building blocks for offspring ...
Silva, Liliana M. R., Lütjohann, Dieter, Hamid, Penny, Velasquez, Zahady D., Kerner, Katharina, Larrazabal, Camilo, Failing, Klaus, Hermosilla, Carlos, Taubert, Anja   +8 more
core   +2 more sources