Results 1 to 10 of about 6,596 (185)

Structural characterization of human cholesterol 7α-hydroxylase [PDF]

Journal of Lipid Research, 2014
Hepatic conversion to bile acids is a major elimination route for cholesterol in mammals. CYP7A1 catalyzes the first and rate-limiting step in classic bile acid biosynthesis, converting cholesterol to 7α-hydroxycholesterol.
Wolfram Tempel, Irina Grabovec, Farrell MacKenzie, Yaroslav V. Dichenko, Sergey A. Usanov, Andrei A. Gilep, Hee-Won Park, Natallia Strushkevich   +7 more
doaj   +2 more sources

Comparison of Cholesterol Lowering Diets: Apple, Casein Cytochrom P450 protein and Cholesterol 7α Hydroxylase Activities in Hamsters [PDF]

, 2010
Lithogenic diet, casein and apple fiber diets were fed to hamsters for 3-5 weeks. For control group, animals were fed on normal Purina chow without any supplement.
Rakesh Sharma, Rakesh K. Tandon
core   +4 more sources

[Cholesterol 7α-Hydroxylase Gene-204A/C Polymorphism in Normal and Gestational Diabetic Pregnancies]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Liu SX, Bai H, Guan LB, Liu XH, Fan P, Zhou M, Wu YJ, Tang FM, Wang YF, Li DH.   +9 more
europepmc   +3 more sources

Expression of cholesterol 7α-hydroxylase and Δ4-3-ketosteroid 5β-reductase genes in rat pancreatic hepatocyte-like cells

Journal of Lipid Research, 1999
Hepatocyte-like cells have been observed in the pancreas of the rat. We examined the bile acid biosynthetic function of these cells to determine whether they were real hepatocytes.
Yoshihisa Ando, Hideyuki Ide, Shuji Kosai, Ryo Kamimura, Yorio Maeda, Shushi Higashi, Toshiaki Setoguchi   +6 more
doaj   +2 more sources

Regulatory effects of sterols and bile acids on hepatic 3-hydroxy-3-methylglutaryl CoA reductase and cholesterol 7α-hydroxylase in the rat

Journal of Lipid Research, 1973
Specific activities of the hepatic microsomal enzymes 3-hydroxy-3-methylglutaryl CoA (HMG CoA) reductase and cholesterol 7α-hydroxylase were studied in rats fed sterols and bile acids.
S. Shefer, S. Hauser, V. Lapar, E.H. Mosbach   +3 more
doaj   +2 more sources

Deficiency of cholesterol 7α-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice. [PDF]

Hepatol Commun, 2018
Donepudi AC, Ferrell JM, Boehme S, Choi HS, Chiang JYL.   +4 more
europepmc   +2 more sources

Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL

Journal of Lipid Research, 2002
Unlike macrophages, the hepatic parenchymal cells express cholesterol-7α-hydroxylase (CYP7A1) which regulates the conversion of cholesterol into bile acids, the major quantitative pathway maintaining cholesterol homeostasis.
Gina L. Moore, Roger A. Davis
doaj   +2 more sources

Short- and long-term effects of ethanol administration in vivo on rat liver HMG-CoA reductase and cholesterol 7α-hydroxylase activities

Journal of Lipid Research, 1977
Short- and long-term effects of ethanol on HMG-CoA reductase (EC 1.1.1.34) and cholesterol 7α-hydroxylase activities in rat liver have been investigated.
M R Lakshmanan, R L Veech
doaj   +2 more sources

Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. [PDF]

J Lipid Res, 2016
Liu H, Pathak P, Boehme S, Chiang JL.
europepmc   +3 more sources

Removal of the bile acid pool upregulates cholesterol 7α-hydroxylase by deactivating FXR in rabbits

Journal of Lipid Research, 2002
We investigated the role of the orphan nuclear receptor farnesoid X receptor (FXR) in the regulation of cholesterol 7α-hydroxylase (CYP7A1), using an in vivo rabbit model, in which the bile acid pool, which includes high affinity ligands for FXR, was ...
Guorong Xu, Lu-xing Pan, Sandra K. Erickson, Barry M. Forman, Benjamin L. Shneider, M. Ananthanarayanan, Xiaogui Li, Sarah Shefer, N. Balasubramanian, Lin Ma, Hitoshi Asaoka, Steven R. Lear, Lien B. Nguyen, Isabelle Dussault, Frederick J. Suchy, G. Stephen Tint, Gerald Salen   +16 more
doaj   +2 more sources