Results 91 to 100 of about 6,635 (224)

Correlation between serum content of the main COPs (cholesterol oxidation products) from autoxidation and cardiovascular risk factors [PDF]

, 2011
BACKGROUND/AIMS: Risk factors for cardiovascular disease (CVD) have been proven to be associated with an increased oxidative stress. Several studies have considered cholesterol oxidation products (COPs) as specific in vivo markers of oxidative stress.
Ansorena-Artieda, D. (Diana), Astiasarán, I. (Iciar), Menendez-Carreño, M. (María), Mugueta, C. (Carmen), Restituto, P. (Patricia), Varo-Cenarruzabeitia, M.N. (Miren Nerea)   +5 more
core  

Bioconversion Property of Tea Leaves Waste by Aspergillus Niger as Functional Fiber to Decrease Blood Lipid [PDF]

, 2010
This research was aimed to find out the change of tea leaves waste fiber on lipid absorption afterbeing fermented by Aspergillus Niger and also to be expected as a model to gain healthy livestockproduct.
Hernaman, I. (I), Kamil, K. A. (K), Lestari, E. S. (E), Tanuwiria, U. H. (U), Toharmat, T. (T)   +4 more
core   +1 more source

Mapping Satellite Glial Cell Heterogeneity Reveals Distinct Spatial Organization and Implies Functional Diversity in the Dorsal Root Ganglion

Advanced Science, Volume 13, Issue 1, 5 January 2026.
Four distinct satellite glial cell subtypes are identified in mouse dorsal root ganglia using single‐cell RNA sequencing and spatial validation. These subtypes show unique marker profiles and anatomical distributions. Human dorsal root ganglia display layered perisomatic organization with differential marker expression.
Ole Andreas Ahlgreen, Mads Würgler Hansen, Jonas Baake, Thomas Engelbrecht Hybel, Rachele Rossi, Xin Lai, Ishwarya Sankaranarayanan, Johanne Amalie Pold, Lin Lin, Line Reinert, Søren Riis Paludan, Theodore John Price, Lone Tjener Pallesen, Christian Bjerggaard Vægter   +13 more
wiley   +1 more source

On the substrate specificity of human CYP27A1

Journal of Lipid Research, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin, Sara von Bahr, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Bile Acids as Key Mediators of the Gut Microbiota–Immune Axis: Potential Biomarker and Therapeutic Perspectives

BioFactors, Volume 52, Issue 1, January/February 2026.
Primary bile acids synthesized in the liver are transformed by gut microbes into secondary bile acids that engage receptors such as FXR and TGR5, thereby modulating immune function and metabolic homeostasis. Dysregulation of these signaling pathways contributes to MASH, NAFLD, IBD, and neurodegenerative disorders, underscoring their relevance as ...
Simone Baldi, Margherita Turrini, Francesco Cei, Marta Menicatti, Gianluca Bartolucci, Amedeo Amedei   +5 more
wiley   +1 more source

Three patients with homozygous familial hypercholesterolemia: Genomic sequencing and kindred analysis. [PDF]

, 2019
BackgroundHomozygous Familial Hypercholesterolemia (HoFH) is an inherited recessive condition associated with extremely high levels of low-density lipoprotein (LDL) cholesterol in affected individuals.
Balamir, Melek, Chu, Catherine, Gonzaludo, Nina, Grenville, Zoe, Kane, John P, Kwok, Pui-Yan, Lao, Richard, Levy-Sakin, Michal, Ma, Walfred, Mak, Angel CY, Malloy, Mary J, Poon, Annie, Pullinger, Clive R, Vaka, Dedeepya, Wong, Karen HY, Wong, Nicolas   +15 more
core   +1 more source

Assay method for mitochondrial sterol 27-hydroxylase with 7α-hydroxy-4-cholesten-3-one as a substrate in the rat liver

Journal of Lipid Research, 2003
Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues ...
Yoshikazu Ota, Tada-Aki Eto, Shun-Ichi Tanaka, Hideto Sueta, Hironori Shiotsuki, Yorio Maeda, Mizuho Une, Kazuo Chijiiwa   +7 more
doaj   +1 more source

Molecular mechanisms for fetal cardiac arrhythmia in intrahepatic cholestasis of pregnancy

, 2010
Intrahepatic cholestasis in pregnancy (ICP) is characterized by raised serum bile acids which can cause fetal complications, including preterm labour and intrauterine death. The fetal death in ICP is not well understood. In this thesis, the mechanisms of
Sheikh Abdul Kadir, Siti Hamimah, Sheikh Abdul Kadir, Siti Hamimah   +1 more
core   +1 more source

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

Cytochrome P450 20A1 in zebrafish: Cloning, regulation and potential involvement in hyperactivity disorders [PDF]

, 2016
Cytochrome P450 (CYP) enzymes for which there is no functional information are considered "orphan" CYPs. Previous studies showed that CYP20A1, an orphan, is expressed in human hippocampus and substantia nigra, and in zebrafish (Danio rerio) CYP20A1 ...
Akira Kubota, Avadhani, Bairoch, Balasubramanian, Barnes, Benjamin Lemaire, Birnie, Boucher, Bryson, Cartharius, Chan, Cheng, Choudhary, Conor M. O'Meara, Coward, Dahlman-Wright, David C. Lamb, Flicek, Giguere, Goldstone, Gorelick, Grandjean, Gupta, Hassan, Honkakoski, Houck, Hulce, James-Zorn, Jared V. Goldstone, Jetten, John J. Stegeman, Jonsson, Jonsson, Kalaany, Kalueff, Krasowski, Krogh, Kubota, Kumar, Lamb, Livak, Maaswinkel, Maximino, Meling, Mitro, Morrison, Nakai, Nelson, Nelson, Otyepka, Petersen, Petersen, Ramos-Santana, Reschly, Robert L. Tanguay, Rost, Sezutsu, Stark, Stark, Strunnikova, Takiguchi, Thisse, Tomaszewska, Truong, Werck-Reichhart, Wirdefeldt, Xu, Yeh, Zhou   +68 more
core   +1 more source