Results 81 to 90 of about 316,404 (122)

Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: evidence that lithocholic acid does not down regulate the hepatic cholesterol 7α-hydroxylase activity in gallstone patients [PDF]

, 1996
It has been proposed that lithocholic acid may have a physiological role for the regulation of bile acid synthesis in humans. In this study, the portal venous concentration and hepatic uptake of unsulfated lithocholic acid was determined in 21 gallstone ...
Björkhem, Ingemar, Hillebrant, Carl-Gustav, Reihnér, Eva, Einarsson, Kurt, Alvelius, Gunvor   +4 more
core   +1 more source

Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL

Journal of Lipid Research, 2002
Unlike macrophages, the hepatic parenchymal cells express cholesterol-7α-hydroxylase (CYP7A1) which regulates the conversion of cholesterol into bile acids, the major quantitative pathway maintaining cholesterol homeostasis.
Gina L. Moore, Roger A. Davis
doaj   +1 more source

CYP7A1 promoter polymorphism −203A>C affects bile salt synthesis rate in patients after ileal resection

Journal of Lipid Research, 2008
Cholesterol 7α-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance.
Martin Leníček, Viktor Komárek, Miluše Zimolová, Jan Kovář, Milan Jirsa, Milan Lukáš, Libor Vítek   +6 more
doaj   +1 more source

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development

iScience
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with ...
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos   +20 more
doaj   +1 more source

Monitoring hepatic cholesterol 7α-hydroxylase activity by assay of the stable bile acid intermediate 7α-hydroxy-4-cholesten-3-one in peripheral blood

Journal of Lipid Research, 2003
We describe an accurate method for monitoring the enzymatic activity of hepatic cholesterol 7α-hydroxylase (C7αOH; CYP7A1), the rate-limiting and major regulatory enzyme in the synthesis of bile acids.
Cecilia Gälman, Ingela Arvidsson, Bo Angelin, Mats Rudling   +3 more
doaj   +1 more source

Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis

Journal of Lipid Research, 2005
Cerebrotendinous xanthomatosis (CTX), sterol 27-hydroxylase (CYP27A1) deficiency, is associated with markedly reduced chenodeoxycholic acid (CDCA), the most powerful activating ligand for farnesoid X receptor (FXR). We investigated the effects of reduced
Akira Honda, Gerald Salen, Yasushi Matsuzaki, Ashok K. Batta, Guorong Xu, Takeshi Hirayama, G. Stephen Tint, Mikio Doy, Sarah Shefer   +8 more
doaj   +1 more source

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

Journal of Lipid Research, 1974
The formation of 5α,6α- and 5β,6β-epoxides of cholesterol and β-sitosterol in rat liver subcellular fractions has been studied. The results show that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols ...
Leif Aringer, Peter Eneroth
doaj   +1 more source

Exploring the Effects of Metabolites from Lactobacillus rhamnosus GM020 and Cyanidin-3-O-Glucoside on Differential Metabolites in the High-fat Diet Mice Liver Based on Metabolomics

Shipin gongye ke-ji
Objective: Investigating the regulatory effects of cyanidin-3-O-glucoside (C3G) and Lactobacillus rhamnosus GM020 metabolite (C3G-GM020) on cholesterol metabolism in high-fat diet-fed mice using untargeted metabolomics.
Sihang WANG, Bin LI, Hui TAN, Xianjun MENG, Yongping XU, Shuying LI, Xiaoru LIU, Yuehua WANG, Yan MA   +8 more
doaj   +1 more source

Circadian transcription of the cholesterol 7α hydroxylase gene may involve the liver-enriched bZIP protein DBP

, 1993
The liver-enriched transcription factor DBP is expressed with a stringent circadian rhythm. We present evidence that DBP is a regulator of the circadian expression of the rat gene encoding cholesterol 7α hydroxylase (C7αH), the rate-limiting enzyme in ...
Schibler, Ulrich, Lavery, Daniel
core   +1 more source

Effects of Ursodesoxycholic Acid on 3-hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol 7α-hydroxylase Activity in Mice Liver Microsomes [PDF]

, 1982
P(論文)The activity of hepatic 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase and 7α-hydroxylase, which are the enzymes controlling the rate of hepatic synthesis respe-ctively, in the cholesterol and bile acids were studied in mice receiving ...
34503, 34502, 中村, 治雄, 倉橋, 昌司, 猪股, 孝四郎, 20391, 吉田, 昌江, 34504   +7 more
core   +1 more source