Results 81 to 90 of about 5,987 (179)

Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes

Journal of Lipid Research, 2001
The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes ...
H. Merzouk, S. Madani, A. Boualga, J. Prost, M. Bouchenak, J. Belleville   +5 more
doaj   +1 more source

The proteomic differences and expression of fatty acid‐binding protein 6 (FABP6) associated with gastrointestinal injury in horses with oral administration of a clinical dose of phenylbutazone

Equine Veterinary Journal, Volume 58, Issue 3, Page 845-856, May 2026.
Abstract Background Phenylbutazone (PBZ) can potentially induce gastrointestinal ulceration, and early detection of PBZ‐induced gastroenteropathy will be useful for the diagnosis, treatment, and prevention of PBZ toxicity. Objectives To identify putative proteins associated with equine gastric ulcer syndrome after clinical dose (4.4 mg/kg ...
Ruethaiwan Vinijkumthorn, Nawarus Prapaiwan, Thanapon Chotikaprakal, Phirom Prompiram, Narumon Phaonakrop, Sittiruk Roytrakul, Parichart Tesena   +6 more
wiley   +1 more source

High cholesterol absorption efficiency interferes with bile acid metabolism and cholesterol elimination from the body

Journal of Internal Medicine, Volume 299, Issue 5, Page 628-638, May 2026.
Abstract Background Elevated low‐density lipoprotein (LDL) cholesterol causes atherosclerotic cardiovascular diseases. Variables of whole‐body cholesterol metabolism, for example, high cholesterol absorption efficiency, might also be atherogenic, whereas the role of bile acids is controversial.
Piia Simonen, Ingmar Wester, Jyri Lommi, Juha Sinisalo, Helena Gylling   +4 more
wiley   +1 more source

Circadian transcription of the cholesterol 7α hydroxylase gene may involve the liver-enriched bZIP protein DBP

, 1993
The liver-enriched transcription factor DBP is expressed with a stringent circadian rhythm. We present evidence that DBP is a regulator of the circadian expression of the rat gene encoding cholesterol 7α hydroxylase (C7αH), the rate-limiting enzyme in ...
Schibler, Ulrich, Lavery, Daniel
core   +1 more source

The Regulatory Role of Iron Transporter SLC39A13 in Liver Fibrosis

Advanced Science, Volume 13, Issue 20, 9 April 2026.
SLC39A13/ZIP13, a newly discovered intracellular iron transporter, delivers iron to the ER/Golgi to catalyze procollagen hydroxylation during collagen maturation. Here, we systematically characterize the cell type‐specific functions of ZIP13 across distinct hepatic cell populations, and identify hepatic stellate cell‐specific ZIP13 as a promising and ...
Shanshan Guo, Yalin Wang, Binyu Lu, Yu Zhang, David M. Frazer, Bing Zhou   +5 more
wiley   +1 more source

On the substrate specificity of human CYP27A1

Journal of Lipid Research, 2003
The mitochondrial sterol 27-hydroxylase (CYP27A1) is required for degradation of the C27-sterol side chain in bile acid biosynthesis. CYP27A1 seems, however, to have roles beyond this, as illustrated by patients with a deficient sterol 27-hydroxylase due
Maria Norlin, Sara von Bahr, Ingemar Björkhem, Kjell Wikvall   +3 more
doaj   +1 more source

Genomic Insights Into Carnivorous Fish in the Characiformes

Ecology and Evolution, Volume 16, Issue 4, April 2026.
This study employed comparative genomic approaches using 12 high‐quality Characiformes genomes (covering nine subfamilies) with zebrafish as an outgroup to explore the molecular mechanisms underlying the carnivorous adaptation of Characiformes. Expanded gene families, positively selected genes, and rapidly evolving genes in carnivorous species were ...
Shihu Zhao, Xuesong Mei, Zhihao Zhang, Tian Xia, Shengyang Zhou, Yuehuan Dong, Shangbin He, Zhicheng Yao, Yuchun Li, Xiufeng Yang, Honghai Zhang   +10 more
wiley   +1 more source

Removal of the bile acid pool upregulates cholesterol 7α-hydroxylase by deactivating FXR in rabbits

Journal of Lipid Research, 2002
We investigated the role of the orphan nuclear receptor farnesoid X receptor (FXR) in the regulation of cholesterol 7α-hydroxylase (CYP7A1), using an in vivo rabbit model, in which the bile acid pool, which includes high affinity ligands for FXR, was ...
Guorong Xu, Lu-xing Pan, Sandra K. Erickson, Barry M. Forman, Benjamin L. Shneider, M. Ananthanarayanan, Xiaogui Li, Sarah Shefer, N. Balasubramanian, Lin Ma, Hitoshi Asaoka, Steven R. Lear, Lien B. Nguyen, Isabelle Dussault, Frederick J. Suchy, G. Stephen Tint, Gerald Salen   +16 more
doaj   +1 more source

Assay method for mitochondrial sterol 27-hydroxylase with 7α-hydroxy-4-cholesten-3-one as a substrate in the rat liver

Journal of Lipid Research, 2003
Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues ...
Yoshikazu Ota, Tada-Aki Eto, Shun-Ichi Tanaka, Hideto Sueta, Hironori Shiotsuki, Yorio Maeda, Mizuho Une, Kazuo Chijiiwa   +7 more
doaj   +1 more source

[Cholesterol 7α-Hydroxylase Gene-204A/C Polymorphism in Normal and Gestational Diabetic Pregnancies]. [PDF]

Sichuan Da Xue Xue Bao Yi Xue Ban, 2023
Liu SX, Bai H, Guan LB, Liu XH, Fan P, Zhou M, Wu YJ, Tang FM, Wang YF, Li DH.   +9 more
europepmc   +1 more source