Results 91 to 100 of about 316,404 (122)

Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7α-hydroxylase in cultured rat hepatocytes and in vivo in the rat

, 1999
Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors are currently in clinical development as potential lipid-lowering and antiatherosclerotic agents.
Havinga, R., Wit, E.C.M. de, Post, S.M., Paul Zoeteweij, J., Princen, H.M.G., Bos, M.H.A., Kuipers, F.   +6 more
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Serum markers of cholesterol 7α hydroxylase activity [PDF]

, 2017
Cholesterol 7-hydroxylase (CYP7A1) is the rate limiting enzyme of the classical pathway of bile acid (BA) synthesis, which catabolizes approximately half of cholesterol in man.
Bohdanecká, Alena
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Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity

, 1990
Feedback regulation of bile acid synthesis by its end products was studied in cultured hepatocytes of young weaned pigs. We previously showed that conversion of exogenous [14C] cholesterol into bile acids was suppressed by addition of bile acids to the ...
Kempen, H.J.M., Voorthuizen, E.M. van, Kwekkeboom, J., Princen, H.M.G.   +3 more
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Cholesterol 7α-hydroxylase

Journal of Lipid Research, 1977
N B Myant, K A Mitropoulos
doaj   +1 more source

Fibrates suppress bile acid synthesis via peroxisome proliferator-activated receptor-α-mediated downregulation of cholesterol 7α-hydroxylase and sterol 27-hydroxylase expression

, 2001
Fibrates are hypolipidemic drugs that affect the expression of genes involved in lipid metabolism by activating peroxisome proliferator-activated receptors (PPARs).
Staels, B., Gervois, P.P., Post, S.M., Princen, H.M.G., Kuipers, F., Duez, H.   +5 more
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Role of the cholesterol 7α- hydroxylase and CYP7A1 gene in human physiology and pathology [PDF]

, 2010
Cholesterol 7α- hydroxylase (CYP7A1) belongs to the big family of cytochrome p450. Biological significance of cholesterol 7α- hydroxylase is associated with beginning of cholesterol transformation to the bile acids.
Żak, Iwona, Iwanicki, Tomasz, Balcerzyk, Anna   +2 more
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Maintenance of bile acid synthesis and cholesterol 7α-hydroxylase activity in cultured rat hepatocytes

, 1990
Addition of foetal-bovine serum to rat hepatocytes cultured in Williams E medium resulted in improved maintenance of bile-acid-synthetic capacity and cholesterol 7α-hydroxylase activity as compared with cultures supplemented with rat or newborn-bovine ...
Meijer, P., Princen, H.M.G.
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Cholesterol 7α-hydroxylase activity and bile acid synthesis in hepatocytes of unweaned and weaned pigs in monolayer culture

, 1990
Activity of cholesterol 7α-hydroxylase (EC 1.14.13.17) in freshly isolated hepatocytes from unweaned piglets (2 to 3 weeks old) was 16-times lower as compared to hepatocytes from weaned piglets (7 to 8 weeks old).
Kempen, H.J.M., Voorthuizen, E.M. van, Kwekkeboom, J., Princen, H.M.G.   +3 more
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阿尔茨海默病患者7α-羟化酶基因多态性与血脂关系的研究

Zhongguo shiyan zhenduanxue, 2009
目的探讨胆固醇7α-羟化酶（cholesterol 7α-hydroxylase,CYP7A1）基因多态性与阿尔茨海默病（AD）的关系。方法用PCR-RFLP方法分析7α-羟化酶A-204C多态性。结果A-204C多态性基因型频率、等位基因A、C频率在组间比较差异无显著性（P>0.05）,但基因型为CC的AD患者,其TC和LDL-C水平显著高于基因型为AC的AD患者（P0.05）,但患者组CC基因型与TC、LDL-C水平密切相关 ...
赵朝贤, 吕英刚, 周涛, 张园, 祝春燕, 刘春燕, 赵晓唐, 贾丽霞, 高丽萍   +8 more
doaj  

Differential feedback regulation of cholesterol 7α-hydroxylase mRNA and transcriptional activity by rat bile acids in primary monolayer cultures of rat hepatocytes

, 1993
We have used primary monolayer cultures of rat hepatocytes to study the effects of physiological concentrations of various bile acids, commonly found in bile of normal rats, on the mechanism of regulation of cholesterol 7α-hydroxylase and bile acid ...
Twisk, J., Princen, H.M.G., Lehmann, E.M.   +2 more
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