Results 91 to 100 of about 5,987 (179)

Serum markers of cholesterol 7α hydroxylase activity [PDF]

, 2017
Cholesterol 7-hydroxylase (CYP7A1) is the rate limiting enzyme of the classical pathway of bile acid (BA) synthesis, which catabolizes approximately half of cholesterol in man.
Bohdanecká, Alena
core  

Role of cholesterol 25 hydroxylase in fibrotic posterior capsular opacification

, 2020
Duncan, Melinda K.Posterior capsular opacification (PCO), a common fibrotic complication of cataract surgery, is a disease which arises from epithelial to mesenchymal transition (EMT) of residual lens epithelial cells (LECs) within the lens capsule.
Stevenson, Joseph M.
core   +1 more source

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α-hydroxylase

, 1990
A complete cDNA clone encoding human cholesterol 7α-hydroxylase has been isolated using a rat P-450ch7α cDNA insert [(1989) FEBS Lett. 257, 97-100] as a probe and totally sequenced.
Okuda, Kyuichiro, Kyuichiro Okuda, Noshiro, Mitsuhide, Mitsuhide Noshiro   +3 more
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Glucose stimulates cholesterol 7α-hydroxylase gene transcription in human hepatocytes[S]

Journal of Lipid Research, 2010
Bile acids play important roles in the regulation of lipid, glucose, and energy homeostasis. Recent studies suggest that glucose regulates gene transcription in the liver.
Tiangang Li, Dipanjan Chanda, Yanqiao Zhang, Hueng-Sik Choi, John Y.L. Chiang   +4 more
doaj   +1 more source

Concentration of unsulfated lithocholic acid in portal and systemic venous plasma: evidence that lithocholic acid does not down regulate the hepatic cholesterol 7α-hydroxylase activity in gallstone patients

, 1996
It has been proposed that lithocholic acid may have a physiological role for the regulation of bile acid synthesis in humans. In this study, the portal venous concentration and hepatic uptake of unsulfated lithocholic acid was determined in 21 gallstone ...
Björkhem, Ingemar, Hillebrant, Carl-Gustav, Reihnér, Eva, Einarsson, Kurt, Alvelius, Gunvor   +4 more
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Expression of cholesterol-7α-hydroxylase in murine macrophages prevents cholesterol loading by acetyl-LDL

Journal of Lipid Research, 2002
Unlike macrophages, the hepatic parenchymal cells express cholesterol-7α-hydroxylase (CYP7A1) which regulates the conversion of cholesterol into bile acids, the major quantitative pathway maintaining cholesterol homeostasis.
Gina L. Moore, Roger A. Davis
doaj   +1 more source

Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis1

Journal of Lipid Research, 2000
A comprehensive study of cholesterol, bile acid, and lipoprotein metabolism was undertaken in two strains of hamster that differed markedly in their response to a sucrose-rich/low fat diet.
Jacqueline Férézou, Murielle Combettes-Souverain, Maâmar Souidi, Jeffery L. Smith, Nathalie Boehler, Fabien Milliat, Erik Eckhardt, Géraldine Blanchard, Michel Riottot, Colette Sérougne, Claude Lutton   +10 more
doaj   +1 more source

CYP7A1 promoter polymorphism −203A>C affects bile salt synthesis rate in patients after ileal resection

Journal of Lipid Research, 2008
Cholesterol 7α-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance.
Martin Leníček, Viktor Komárek, Miluše Zimolová, Jan Kovář, Milan Jirsa, Milan Lukáš, Libor Vítek   +6 more
doaj   +1 more source

7α-Hydroxylation of 26-hydroxycholesterol, 3β-hydroxy-5-cholestenoic acid and 3β-hydroxy-5-cholenoic acid by cytochrome P-450 in pig liver microsomes

, 1992
Pig liver microsomes were found to catalyze the 7α-hydroxylation of several potential bile acid precursors besides cholesterol. 26-Hydroxycholesterol, 3β-hydroxy-5-cholestenoic acid and 3β-hydroxy-5-cholenoic acid were all efficiently converted into the ...
Junichi Shoda, Jan Sjövall, Magnus Axelson, Anders Toll, Toll, Anders, Axelson, Magnus, SHODA, J, AXELSON, M, WIKVALL, K, Wikvall, Kjell, SJOVALL, J, Sjövall, Jan, Kjell Wikvall, Shoda, Junichi, TOLL, A   +14 more
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