Results 71 to 80 of about 316,404 (122)

Oxysterols in Cancer: From Biosynthesis and Pathophysiology to Targeted Therapeutics

MedComm – Oncology, Volume 5, Issue 3, September 2026.
Mechanisms by which oxysterol targeting may enhance immunotherapy efficacy. This figure illustrates potential metabolic interventions that may improve antitumor immunity by modulating oxysterol related pathways. CH25H modulation may reduce 25‐HC accumulation, promote the conversion of cold tumors into hot tumors, and increase T cell infiltration and PD‐
Haili Shang, Yongsheng Li
wiley   +1 more source

Removal of the bile acid pool upregulates cholesterol 7α-hydroxylase by deactivating FXR in rabbits

Journal of Lipid Research, 2002
We investigated the role of the orphan nuclear receptor farnesoid X receptor (FXR) in the regulation of cholesterol 7α-hydroxylase (CYP7A1), using an in vivo rabbit model, in which the bile acid pool, which includes high affinity ligands for FXR, was ...
Guorong Xu, Lu-xing Pan, Sandra K. Erickson, Barry M. Forman, Benjamin L. Shneider, M. Ananthanarayanan, Xiaogui Li, Sarah Shefer, N. Balasubramanian, Lin Ma, Hitoshi Asaoka, Steven R. Lear, Lien B. Nguyen, Isabelle Dussault, Frederick J. Suchy, G. Stephen Tint, Gerald Salen   +16 more
doaj   +1 more source

Assay method for mitochondrial sterol 27-hydroxylase with 7α-hydroxy-4-cholesten-3-one as a substrate in the rat liver

Journal of Lipid Research, 2003
Mitochondrial sterol 27-hydroxylase (EC 1.14.13.15) is an important enzyme, not only in the formation of bile acids from cholesterol intermediates in the liver but also in the removal of cholesterol by side chain hydroxylation in extrahepatic tissues ...
Yoshikazu Ota, Tada-Aki Eto, Shun-Ichi Tanaka, Hideto Sueta, Hironori Shiotsuki, Yorio Maeda, Mizuho Une, Kazuo Chijiiwa   +7 more
doaj   +1 more source

Expression of key enzymes in bile acid biosynthesis during development: CYP7B1-mediated activities show tissue-specific differences

Journal of Lipid Research, 2002
The developmental variation of cytochrome P450 (CYP)7A1, CYP7B1, CYP27A1, and 3β-hydroxy-Δ5-C27-steroid dehydrogenase, key enzymes in bile acid biosynthesis, were investigated in pigs of different ages.
Maria Norlin
doaj   +1 more source

Lipoprotein cholesterol uptake mediates up-regulation of bile-acid synthesis by increasing cholesterol 7α-hydroxylase but not sterol 27-hydroxylase gene expression in cultured rat hepatocytes

, 1999
Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7α-hydroxylase expression.
Fits, L. van der, Twisk, J., Mager, W.H., Wit, E.C.M. de, Post, S.M., Princen, H.M.G., Hoekman, M.F.M.   +6 more
core  

Different hepatocytes express the cholesterol 7Α-hydroxylase gene during its circadian modulation in vivo [PDF]

, 1995
Cholesterol 7Α-hydroxylase, the rate-limiting enzyme in bile salt synthesis from cholesterol is a P450 enzyme (CYP7A). Its expression and activity are regulated by bile salts, cholesterol, hormones and a circadian modulator.
Shen, Cynthia S., Guibert, Edgardo, Bilir, Bahri M., Gumucio, Jorge J., Berkowitz, Caryn M.   +4 more
core   +1 more source

Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis1

Journal of Lipid Research, 2000
A comprehensive study of cholesterol, bile acid, and lipoprotein metabolism was undertaken in two strains of hamster that differed markedly in their response to a sucrose-rich/low fat diet.
Jacqueline Férézou, Murielle Combettes-Souverain, Maâmar Souidi, Jeffery L. Smith, Nathalie Boehler, Fabien Milliat, Erik Eckhardt, Géraldine Blanchard, Michel Riottot, Colette Sérougne, Claude Lutton   +10 more
doaj   +1 more source

HMG-CoA reductase and cholesterol 7-hydroxylase in human liver

, 1984
The activities of HMGCoA reductase and cholesterol 7α-hydroxylase were assayed in liver biopsies of patients with or without cholestyramine treatment.
G. GALLI, E. BOSISIO, G. CIGHETTI, R. TRITAPEPE, M. GALLI KIENLE   +4 more
core   +1 more source

Molecular cloning and sequence analysis of cDNA encoding human cholesterol 7α-hydroxylase [PDF]

, 1990
A complete cDNA clone encoding human cholesterol 7α-hydroxylase has been isolated using a rat P-450ch7α cDNA insert [(1989) FEBS Lett. 257, 97-100] as a probe and totally sequenced.
Okuda, Kyuichiro, Kyuichiro Okuda, Noshiro, Mitsuhide, Mitsuhide Noshiro   +3 more
core   +1 more source

Glucose stimulates cholesterol 7α-hydroxylase gene transcription in human hepatocytes[S]

Journal of Lipid Research, 2010
Bile acids play important roles in the regulation of lipid, glucose, and energy homeostasis. Recent studies suggest that glucose regulates gene transcription in the liver.
Tiangang Li, Dipanjan Chanda, Yanqiao Zhang, Hueng-Sik Choi, John Y.L. Chiang   +4 more
doaj   +1 more source