Results 51 to 60 of about 316,404 (122)
Journal of Lipid Research, 2000 : In classic cholic acid biosynthesis, a series of ring modifications of cholesterol precede side chain cleavage and yield 5β-cholestane-3α, 7α, 12α-triol.
Akira Honda +7 more
doaj +1 more source
Aging Cell, Volume 25, Issue 10, October 2026.α‐Syn‐HDOs protect dopaminergic neurons by enhancing BDNF–TrkB signaling through the inhibition of abnormally elevated α‐Syn. These findings position α‐Syn‐HDOs as promising therapeutic candidates for PD and suggest that BDNF may serve as a potential diagnostic biomarker or indicator of treatment efficacy.
Xuenan Wang +9 more
wiley +1 more source
Biochemical site of regulation of bile acid biosynthesis in the rat
Journal of Lipid Research, 1970 The production of bile salts by rat liver is regulated by a feedback mechanism, but it is not known which enzyme controls endogenous bile acid synthesis.
SARAH SHEFER +3 more
doaj +1 more source
The FASEB Journal, Volume 40, Issue 17, 15 September 2026.Dietary components shape the gut microbiome, which modifies bile acids through transformations. The resulting bile acid pool is sensed by host receptors to regulate immunity, metabolism, and intestinal function. Targeted bile acid measurements provide a unifying readout to study diet‐microbiome interactions and to develop next‐generation dietary ...
Jason Dichter
wiley +1 more source
Advanced Science, Volume 13, Issue 53, 24 September 2026.Lipoic acid synthase (lias) can regulate α‐KG levels through lipoylation, thereby negatively regulating HIF‐1α protein levels via PHD under hypoixa. The Hap2 allele of lias exhibits lower expression levels than Hap1, leading to the accumulation of more HIF‐1α protein and thereby enhancing hypoxia tolerance. ABSTRACT Hypoxia stress seriously affects the
Jie Ding +7 more
wiley +1 more source
The acidic pathway of bile acid synthesis: Not just an alternative pathway
Liver Research, 2019 Over the last two decades, the prevalence of obesity, and metabolic syndromes (MS) such as non-alcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus (T2DM), have dramatically increased.
William M. Pandak, Genta Kakiyama
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.GPR183/EBI2 links oxysterol metabolism with immune‐cell positioning and macrophage function in tuberculosis. The 7α,25‐OHC‐GPR183 axis regulates macrophage trafficking, autophagy and type I interferon responses. GPR183 represents a potential immunometabolic target for host‐directed therapy against tuberculosis..
Junfei Wang +4 more
wiley +1 more source
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Piezo1 functions as a context‐dependent mechanotransduction node linking mechanical cues to inflammation, tissue remodelling and metabolic regulation in digestive homeostasis and disease. In epithelial, immune, stromal and endocrine cells, Piezo1‐mediated Ca2+ signalling contributes to barrier and mucus homeostasis, epithelial renewal and repair ...
Yuan Xia +6 more
wiley +1 more source
Partial Purification and Characterization of Cholesterol 7α-Hydroxylase from Guinea Pig [PDF]
, 1987 Cholesterol 7α-hydroxylase (cholesterol, NADPH: oxygen oxidoreductase, 7α-xhydroxylating, EC 1.14.13.17), was partially purified from liver microsomes of guinea pig. The purified sample showed a specific activity of 1.
NAKAI, Taketomi
core
Regulation of rat liver microsomal cholesterol 7α-hydroxylase by MgATP: Effect of pH
, 1983 Cholesterol 7α-hydroxylase when assayed under conditions that favour phosphorylation can be activated or inactivated by MgATP, depending on ATP concentration and the pH of the incubation medium. Maximum stimulation of 7α-hydroxylase was obtained with 0.5
Praga Pillay S., Kwok C.T., Hardie I.R.
core +1 more source