Results 51 to 60 of about 5,987 (179)
Neuroprotective effects of ursodeoxycholic acid in Parkinson's disease and Alzheimer's disease
Neuroprotection, EarlyView.In Parkinson's disease (PD) and Alzheimer's disease (AD), various shared pathological mechanisms exist. UDCA has been shown to exert neuroprotective effects in preclinical and clinical studies. Such effects include the mitigation of neuroinflammation as well as rescue effects on mitochondrial dysfunction, oxidative stress, impaired autophagy, and ...
Ashley En Yi Chong +3 more
wiley +1 more source
Gene expression of hepatic cholesterol 7α-hydroxylase in the course of puromycin-induced nephrosis
, 1996 Gene expression of hepatic cholesterol 7α-hydroxylase in the course of puromycin-induced nephrosis. Cholesterol conversion to and biliary excretion of bile acids represents the principal pathway of cholesterol catabolism in mammals.
Liang, Kai Hui +2 more
core +1 more source
Regulation of bile acid biosynthesis by hepatocyte nuclear factor 4α
Journal of Lipid Research, 2006 Hepatocyte nuclear factor 4α (HNF4α) regulates many genes that are preferentially expressed in liver. Mice lacking hepatic expression of HNF4α (HNF4αΔL) exhibited markedly increased levels of serum bile acids (BAs) compared with HNF4α-floxed (HNF4αF/F ...
Yusuke Inoue +10 more
doaj +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Background Cell senescence (CS) and lipid metabolism (LM) disorders have been reported in chronic rhinosinusitis with nasal polyps (CRSwNP). However, the mechanism is still unclear. Methods Data were obtained from public databases; differential expression analysis and machine learning were performed to identify biomarkers and to understand the
Hui‐Yi Deng +3 more
wiley +1 more source
, 2003 HMG-CoA reductase, cholesterol 7α-hydroxylase, LCAT, ACAT, LDL receptor, and SRB-1 in hereditary analbuminemia.BackgroundHereditary analbuminemia is associated with hypercholesterolemia, which has been shown to be primarily caused by increased ...
Liang, Kaihui, Vaziri, Nosratola D.
core +1 more source
The FEBS Journal, EarlyView.Fetal growth restriction is associated with placental metabolic adaptations. In small‐for‐gestational‐age placenta (SGA), cholesterol receptors and steroidogenic enzymes are upregulated, enhancing steroidogenesis. NAD salvage pathway is also increased to support NADP+/NADPH requirements.
Serena Xodo +4 more
wiley +1 more source
Regulation of rat liver microsomal cholesterol 7α-hydroxylase by MgATP: Effect of pH
, 1983 Cholesterol 7α-hydroxylase when assayed under conditions that favour phosphorylation can be activated or inactivated by MgATP, depending on ATP concentration and the pH of the incubation medium. Maximum stimulation of 7α-hydroxylase was obtained with 0.5
Praga Pillay S., Kwok C.T., Hardie I.R.
core +1 more source
Different hepatocytes express the cholesterol 7Α-hydroxylase gene during its circadian modulation in vivo [PDF]
, 1995 Cholesterol 7Α-hydroxylase, the rate-limiting enzyme in bile salt synthesis from cholesterol is a P450 enzyme (CYP7A). Its expression and activity are regulated by bile salts, cholesterol, hormones and a circadian modulator.
Shen, Cynthia S. +4 more
core +1 more source
Journal of Lipid Research, 1998 Reduced cholesterol synthesis has been reported in patients with primary biliary cirrhosis but no data are available on changes in cholesterol catabolism induced by the disease.
M. Del Puppo +4 more
doaj +1 more source
Journal of Pineal Research, Volume 78, Issue 4, July 2026.ABSTRACT Hearing impairment is attributed to factors such as age, genetic predisposition, and environmental influences, among which environmental factors are considered modifiable. Among various environmental factors, the role of poor lifestyle habits is particularly critical, yet the specific mechanisms by which they contribute to hearing damage ...
Siyu Qiu +4 more
wiley +1 more source