Results 61 to 70 of about 5,987 (179)

Partial Purification and Characterization of Cholesterol 7α-Hydroxylase from Guinea Pig [PDF]

, 1987
Cholesterol 7α-hydroxylase (cholesterol, NADPH: oxygen oxidoreductase, 7α-xhydroxylating, EC 1.14.13.17), was partially purified from liver microsomes of guinea pig. The purified sample showed a specific activity of 1.
NAKAI, Taketomi
core  

Regulation of cholesterol-7α-hydroxylase: BAREly missing a SHP

Journal of Lipid Research, 2002
Cholesterol-7α-hydroxylase (CYP7A1) regulates the pathway through which cholesterol is converted into bile acids. The unique detergent properties of bile acids are essential for the digestion and intestinal absorption of hydrophobic nutrients. Bile acids
Roger A. Davis, Jon H. Miyake, To Yuen Hui, Nathanael J. Spann   +3 more
doaj   +1 more source

Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
Microgravity (μG) reduces mechanical tactile stimulation in Caenorhabditis elegans, causing neuromuscular decline, altered gene expression, synaptic defects, and accelerated aging phenotypes. The gentle‐touch mechanoreceptor MEC‐4 mediates μG‐induced body length reduction and extracellular matrix gene downregulation.
Atsushi Higashitani, Je‐Hyun Moon, Jong‐In Hwang, Nahoko Higashitani, Toko Hashizume, Ahmad Aisha Abu, Kazuki Ooizumi, Ibuki Sazuka, Yoshimitsu Hashizume, Masumi Umehara, Alfredo V. Alcantara Jr, Ban‐seok Kim, Timothy Etheridge, Nathaniel J. Szewczyk, Takaaki Abe, Jin I. Lee, Akira Higashibata   +16 more
wiley   +1 more source

Lipoprotein cholesterol uptake mediates upregulation of bile acid synthesis by increasing cholesterol 7a-hydroxylase but not sterol 27- hydroxylase gene expression in cultured rat hepatocytes.

, 1999
Lipoproteins may supply substrate for the formation of bile acids, and the amount of hepatic cholesterol can regulate bile-acid synthesis and increase cholesterol 7α-hydroxylase expression.
Twisk, J.W.R., Wit, E.C.M., Mager, W.H., van der Fits, L.T.E., Post, S.M., Princen, H.M.G., Hoekman, M.F.M.   +6 more
core   +1 more source

A Nanoparticle‐Integrated Complete Manufacturing Pipeline of Chemically Engineered Exosomes

Advanced Science, Volume 13, Issue 32, 9 June 2026.
We report a novel manufacture technology of chemically engineered exosomes. The four steps of manufacturing, i.e., biogenesis, loading, isolation, and storage, are integrated by the use of a nanoparticle. The manufacture technology incorporates three innovative components, i.e., a new nano‐bio effect, a new composite nanoparticle, and a new isolation ...
Xiaowei Wen, Zixing Xu, Zerun Hao, Yanming Chen, Kai Xie, Haofan Yin, Xueying Wang, Jie Min, Sihan Sun, Baiding Chen, Chengxiu Ling, Mingming Xu, Yizhao Chen, Gang Ruan   +13 more
wiley   +1 more source

HMG-CoA reductase, cholesterol 7α-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X

, 2004
HMG-CoA reductase, cholesterol 7α-hydroxylase, LDL receptor, SR-B1, and ACAT in diet-induced syndrome X.BackgroundLong-term consumption of Western diets can lead to acquired syndrome X, which presents with obesity, insulin resistance, hypertension ...
Roberts, Christian K., Kim, Choong H., Liang, Kaihui, Barnard, R. James, Vaziri, Nosratola D.   +4 more
core   +1 more source

Regulation of 25- and 27-hydroxylation side chain cleavage pathways for cholic acid biosynthesis in humans, rabbits, and mice: assay of enzyme activities by high-resolution gas chromatography–mass spectrometry

Journal of Lipid Research, 2000
: In classic cholic acid biosynthesis, a series of ring modifications of cholesterol precede side chain cleavage and yield 5β-cholestane-3α, 7α, 12α-triol.
Akira Honda, Gerald Salen, Sarah Shefer, Yasushi Matsuzaki, Guorong Xu, Ashok K. Batta, G. Stephen Tint, Naomi Tanaka   +7 more
doaj   +1 more source

Enteromorpha prolifera Polysaccharide Alleviates Type 2 Diabetes via the Gut Microbiota–Liver Axis to Modulate Cholesterol Metabolism

Food Science &Nutrition, Volume 14, Issue 6, June 2026.
Enteromorpha prolifera polysaccharides may help restore lipid metabolism homeostasis by gently remodeling the gut microbiota to enrich beneficial bacteria and SCFAs, which in turn appears to modulate hepatic functions through the portal vein by downregulating cholesterol synthesis and promoting its metabolism. This coordinated process potentially leads
Liuying Zhu, Xusheng Wen, Wenrong Zhu, Xueqian Hu, Yanqun Xu, Xin Peng   +5 more
wiley   +1 more source

Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7α-hydroxylase in rats with subtotal nephrectomy

, 1994
Post-transcriptional regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and cholesterol 7α-hydroxylase in rats with subtotal nephrectomy. Chronic renal failure is associated with hyperlipidemia and atherosclerosis.
Krieg, Richard J., Vlahcevic, Z. Reno, Pandak, William M., Chan, James C.M., Heuman, D.M., Hanna, James D.   +5 more
core   +1 more source

Biochemical site of regulation of bile acid biosynthesis in the rat

Journal of Lipid Research, 1970
The production of bile salts by rat liver is regulated by a feedback mechanism, but it is not known which enzyme controls endogenous bile acid synthesis.
SARAH SHEFER, SUSAN HAUSER, IHOR BEKERSKY, ERWIN H. MOSBACH   +3 more
doaj   +1 more source