Results 101 to 110 of about 316,404 (122)

Dexamethasone regulates bile acid synthesis in monolayer cultures of rat hepatocytes by induction of cholesterol 7α-hydroxylase

, 1989
To study the effect of steroid hormones on bile acid synthesis by cultured rat hepatocytes, cells were incubated with various amounts of these compounds during 72 h and conversion of [4-14C]cholesterol into bile acids was measured.
Meijer, P., Hofstee, B., Princen, H.M.G.
core  

Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives [Elektronisk resurs]

, 2000
Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol ...
Norlin, Maria,
core   +1 more source

Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives

, 2000
Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol ...
Norlin, Maria
core   +1 more source

Cholesterol 7α-hydroxylase deficiency in mice on an APOE*3-Leiden background increases hepatic ABCA1 mRNA expression and HDL-cholesterol

, 2006
OBJECTIVE - High-density lipoprotein (HDL) plays a key role in protection against development of atherosclerosis by reducing inflammation, protecting against LDL oxidation, and promoting reverse cholesterol transport from peripheral tissues to the liver ...
Hoogt, C.C. van der, Staels, B., Hoekstra, M., Post, S.M., Groenendijk, M., Princen, H.M.G., Rensen, P.C.N., Luc, G., Fievet, C.   +8 more
core  

The role of cholesterol-7alpha-hydroxylase in cholesterolemia regulation

, 2013
Cholesterol 7α-hydroxylase (CYP7A1) is an enzyme catalyzing the first step of conversion of cholesterol to bile acids. The enzyme activity is regulated to supply enough bile salts necessary for absorption of fats in the intestine.
Procházková, Martina
core  

Cafestol, the Cholesterol-Raising Factor in Boiled Coffee, Suppresses Bile Acid Synthesis by Downregulation of Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase in Rat Hepatocytes

Arteriosclerosis, Thrombosis, and Vascular Biology, 1997
Consumption of boiled coffee raises serum cholesterol levels in humans. The diterpenes cafestol and kahweol in boiled coffee have been found to be responsible for the increase.
Hans M Princen, Sabine M Post
exaly   +3 more sources

Assay of cholesterol 7α-hydroxylase activity in rat hepatocytes in primary monolayer culture

Analytical Biochemistry, 1988
A sensitive and precise method is described to assay cholesterol 7α-hydroxylase activity in homogenates of rat hepatocytes cultured in monolayers for up to 76 h. The assay is based on measurement of the amount of radioactive cholesterol converted into 7α-
Hans M Princen, J Kwekkeboom, H J Kempen
exaly   +1 more source

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Anticonvulsive properties of soticlestat, a novel cholesterol 24-hydroxylase inhibitor

Epilepsia, 2022
Cameron S Metcalf, Shinji Fujimoto, Toshiya Nishi   +2 more
exaly  

Cholesterol 25-hydroxylase suppresses porcine deltacoronavirus infection by inhibiting viral entry

Virus Research, 2021
Shaobo Xiao, Liurong Fang, Puxian Fang
exaly  

Synthesis and pharmacokinetic study of a C-labeled cholesterol 24-hydroxylase inhibitor using ‘in-loop’ [C]CO fixation method

Bioorganic and Medicinal Chemistry Letters, 2020
Natalia Mast, Tuo Shao, Jiahui Chen
exaly