Results 101 to 110 of about 5,987 (179)

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development

iScience
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with ...
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos   +20 more
doaj   +1 more source

Monitoring hepatic cholesterol 7α-hydroxylase activity by assay of the stable bile acid intermediate 7α-hydroxy-4-cholesten-3-one in peripheral blood

Journal of Lipid Research, 2003
We describe an accurate method for monitoring the enzymatic activity of hepatic cholesterol 7α-hydroxylase (C7αOH; CYP7A1), the rate-limiting and major regulatory enzyme in the synthesis of bile acids.
Cecilia Gälman, Ingela Arvidsson, Bo Angelin, Mats Rudling   +3 more
doaj   +1 more source

Disrupted coordinate regulation of farnesoid X receptor target genes in a patient with cerebrotendinous xanthomatosis

Journal of Lipid Research, 2005
Cerebrotendinous xanthomatosis (CTX), sterol 27-hydroxylase (CYP27A1) deficiency, is associated with markedly reduced chenodeoxycholic acid (CDCA), the most powerful activating ligand for farnesoid X receptor (FXR). We investigated the effects of reduced
Akira Honda, Gerald Salen, Yasushi Matsuzaki, Ashok K. Batta, Guorong Xu, Takeshi Hirayama, G. Stephen Tint, Mikio Doy, Sarah Shefer   +8 more
doaj   +1 more source

Formation and metabolism in vitro of 5,6-epoxides of cholesterol and β-sitosterol

Journal of Lipid Research, 1974
The formation of 5α,6α- and 5β,6β-epoxides of cholesterol and β-sitosterol in rat liver subcellular fractions has been studied. The results show that the epoxidation seems to occur only in connection with the nonspecific tissue oxidation of the sterols ...
Leif Aringer, Peter Eneroth
doaj   +1 more source

Exploring the Effects of Metabolites from Lactobacillus rhamnosus GM020 and Cyanidin-3-O-Glucoside on Differential Metabolites in the High-fat Diet Mice Liver Based on Metabolomics

Shipin gongye ke-ji
Objective: Investigating the regulatory effects of cyanidin-3-O-glucoside (C3G) and Lactobacillus rhamnosus GM020 metabolite (C3G-GM020) on cholesterol metabolism in high-fat diet-fed mice using untargeted metabolomics.
Sihang WANG, Bin LI, Hui TAN, Xianjun MENG, Yongping XU, Shuying LI, Xiaoru LIU, Yuehua WANG, Yan MA   +8 more
doaj   +1 more source

Bile acids exert negative feedback control on bile acid synthesis in cultured pig hepatocytes by suppression of cholesterol 7α-hydroxylase activity

, 1990
Feedback regulation of bile acid synthesis by its end products was studied in cultured hepatocytes of young weaned pigs. We previously showed that conversion of exogenous [14C] cholesterol into bile acids was suppressed by addition of bile acids to the ...
Kempen, H.J.M., Voorthuizen, E.M. van, Kwekkeboom, J., Princen, H.M.G.   +3 more
core  

Green tea catechin enhances cholesterol 7α-hydroxylase gene expression in HepG2 cells

, 2017
Green tea catechins are known to have hypocholesterolaemic effects in animals and human subjects. In the present study, we investigated the effects of green tea catechins on the mRNA level and promoter activity of hepatic cholesterol 7α-hydroxylase ...
김양하
core   +1 more source

Acyl-coenzyme A:cholesterol acyltransferase inhibitor, avasimibe, stimulates bile acid synthesis and cholesterol 7α-hydroxylase in cultured rat hepatocytes and in vivo in the rat

, 1999
Acyl-coenzyme A:cholesterol acyltransferase (ACAT) inhibitors are currently in clinical development as potential lipid-lowering and antiatherosclerotic agents.
Havinga, R., Wit, E.C.M. de, de Wit, ECM, Post, S.M., Post, SM, Kuipers, F, Paul Zoeteweij, J., Kuipers, F; id_orcid, Princen, HMG, Bos, MHA, Princen, H.M.G., Zoeteweij, JP, Bos, M.H.A., Kuipers, F., Havinga, R   +14 more
core  

Maintenance of bile acid synthesis and cholesterol 7α-hydroxylase activity in cultured rat hepatocytes

, 1990
Addition of foetal-bovine serum to rat hepatocytes cultured in Williams E medium resulted in improved maintenance of bile-acid-synthetic capacity and cholesterol 7α-hydroxylase activity as compared with cultures supplemented with rat or newborn-bovine ...
Meijer, P., Princen, H.M.G.
core  

Effects of compactin (ML-236 B) on biliary lipid composition and cholesterol catabolism in the hamster

, 1982
The effects of compactin (ML-236 B) administration on bile saturation and on the activity of hepatic HMG-CoA reductase, acylCoA cholesterol acyl transferase and cholesterol 7α-hydroxylase were studied in hamsters fed either a standard or a lithogenic ...
R. Paoletti, G. Cighetti, C. Di Padova, G. Galli, M. Galli Kienle, E. Bosisio, P. Rovagnati   +6 more
core   +1 more source