Results 111 to 120 of about 5,987 (179)

Dietary fish oil up-regulates cholesterol 7α-hydroxylase mRNA in mouse liver leading to an increase in bile acid and cholesterol excretion

, 2004
To investigate the molecular events controlling reverse cholesterol transport, we compared gene expression of normal mouse liver to that of mice fed a long chain (LC) ω-3 fatty acid-enriched diet.
Darmon, Michel, Marie-France Dumon, Annie M. Bérard, Dumon, Marie-France, Michel Darmon, Bérard, Annie M.   +5 more
core   +1 more source

Cholesterol 7α-hydroxylase

Journal of Lipid Research, 1977
N B Myant, K A Mitropoulos
doaj   +1 more source

Role of the cholesterol 7α- hydroxylase and CYP7A1 gene in human physiology and pathology

, 2010
Cholesterol 7α- hydroxylase (CYP7A1) belongs to the big family of cytochrome p450. Biological significance of cholesterol 7α- hydroxylase is associated with beginning of cholesterol transformation to the bile acids.
Żak, Iwona, Iwanicki, Tomasz, Balcerzyk, Anna   +2 more
core  

Cholesterol-Lowering Activity of Tartary Buckwheat Protein

, 2017
Previous research has shown that Tartary buckwheat flour is capable of reducing plasma cholesterol. The present study was to examine the effect of rutin and Tartary buckwheat protein on plasma total cholesterol (TC) in hypercholesterolemia hamsters.
Zhen-Yu Chen (229195), Ning Liang (3777817), Wangjun Hao (3777811), Hanyue Zhu (3777814), Zouyan He (3777823), Jianhui Liu (475329), Yuk Man Li (3777808), Yimin Zhao (689844), Ka Ying Ma (1761349), Chengnan Zhang (3777820), Rui Zhang (13940), Rui Jiao (553003)   +11 more
core   +1 more source

Effects of Ursodesoxycholic Acid on 3-hydroxy-3-methylglutaryl Coenzyme A Reductase and Cholesterol 7α-hydroxylase Activity in Mice Liver Microsomes

, 1982
P(論文)The activity of hepatic 3-hydroxy-3-methylglutaryl-CoA(HMG-CoA) reductase and 7α-hydroxylase, which are the enzymes controlling the rate of hepatic synthesis respe-ctively, in the cholesterol and bile acids were studied in mice receiving ...
34503, 34502, 中村, 治雄, 倉橋, 昌司, 猪股, 孝四郎, 20391, 吉田, 昌江, 34504   +7 more
core  

Transcriptional Activation of the Cholesterol 7α-Hydroxylase Gene (CYP7A) by Nuclear Hormone Receptors

, 1998
The gene encoding cholesterol 7α-hydroxylase (CYP7A), the rate-limiting enzyme in bile acid synthesis, is transcriptionally regulated by bile acids and hormones. Previously, we have identified two bile acid response elements (BARE) in the promoter of the
Sadeghpour, Azita, Chiang, John Y.L., Stroup, Diane, Crestani, Maurizio, Galli, Giovanni   +4 more
core   +1 more source

阿尔茨海默病患者7α-羟化酶基因多态性与血脂关系的研究

Zhongguo shiyan zhenduanxue, 2009
目的探讨胆固醇7α-羟化酶（cholesterol 7α-hydroxylase,CYP7A1）基因多态性与阿尔茨海默病（AD）的关系。方法用PCR-RFLP方法分析7α-羟化酶A-204C多态性。结果A-204C多态性基因型频率、等位基因A、C频率在组间比较差异无显著性（P>0.05）,但基因型为CC的AD患者,其TC和LDL-C水平显著高于基因型为AC的AD患者（P0.05）,但患者组CC基因型与TC、LDL-C水平密切相关 ...
赵朝贤, 吕英刚, 周涛, 张园, 祝春燕, 刘春燕, 赵晓唐, 贾丽霞, 高丽萍   +8 more
doaj  

Deficiency of cholesterol 7α-hydroxylase in bile acid synthesis exacerbates alcohol-induced liver injury in mice. [PDF]

Hepatol Commun, 2018
Donepudi AC, Ferrell JM, Boehme S, Choi HS, Chiang JYL.   +4 more
europepmc   +1 more source

The pharmacological exploitation of cholesterol 7alpha-hydroxylase, the key enzyme in bile acid synthesis : from binding resins to chromatin remodelling to reduce plasma cholesterol

, 2007
Mammals dispose of cholesterol mainly through 7α-hydroxylated bile acids, and the enzyme catalyzing the 7α-hydroxylation, cholesterol 7α-hydroxylase (CYP7A1), has a deep impact on cholesterol homeostasis.
F. Gilardi, Emma De Fabiani, Maurizio Crestani, M. Crestani, Federica Gilardi, Cristina Godio, C. Godio, Donatella Caruso, E.S.R. De Fabiani, N. Mitro, Elena Scotti, E. Scotti, D. Caruso, Nico Mitro   +13 more
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Effect of iron on cholesterol 7α-hydroxylase expression in alcohol-induced hepatic steatosis in mice. [PDF]

J Lipid Res, 2017
Liang H, Huang H, Tan PZ, Liu Y, Nie JH, Zhang YT, Zhang KL, Diao Y, He Q, Hou BY, Zhao TT, Li YZ, Lv GX, Lee KY, Gao X, Zhou LY.   +15 more
europepmc   +1 more source