Results 121 to 130 of about 5,987 (179)

Liver disease in infancy caused by oxysterol 7α-hydroxylase deficiency: successful treatment with chenodeoxycholic acid

, 2014
A child of consanguineous parents of Pakistani origin developed jaundice at 5 weeks and then, at 3 months, irritability, a prolonged prothrombin time, a low albumin, and episodes of hypoglycaemia. Investigation showed an elevated alanine aminotransferase
Akihiko Kimura, Fanny Mochel, Dongling Dai, Peter J. Crick, Julie Lavie, Tatsuki Mizuochi, Hiroshi Nittono, Yuqin Wang, William Griffiths, Patricia McClean, Peter T. Clayton, Cyril Goizet, Philippa B. Mills, Jens Stahlschmidt, Isabelle Coupry, Karin Schwarz, Emma Footitt, Paul Gissen, William J. Griffiths   +18 more
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Cholesterol 7α-hydroxylase protects the liver from inflammation and fibrosis by maintaining cholesterol homeostasis. [PDF]

J Lipid Res, 2016
Liu H, Pathak P, Boehme S, Chiang JL.
europepmc   +1 more source

The role of cholesterol-7alpha-hydroxylase in cholesterolemia regulation

, 2013
Cholesterol 7α-hydroxylase (CYP7A1) is an enzyme catalyzing the first step of conversion of cholesterol to bile acids. The enzyme activity is regulated to supply enough bile salts necessary for absorption of fats in the intestine.
Procházková, Martina
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Infant Formula Feeding Increases Hepatic Cholesterol 7α Hydroxylase (CYP7A1) Expression and Fecal Bile Acid Loss in Neonatal Piglets. [PDF]

J Nutr, 2018
Mercer KE, Bhattacharyya S, Diaz-Rubio ME, Piccolo BD, Pack LM, Sharma N, Chaudhury M, Cleves MA, Chintapalli SV, Shankar K, Ronis MJJ, Yeruva L.   +11 more
europepmc   +1 more source

Cytochrome P450 Enzymes in the Metabolism of Cholesterol and Cholesterol Derivatives

, 2000
Cholesterol is metabolized to a variety of important biological products in the body including bile acids and vitamin D. The present investigation is focused on enzymes that catalyze 7α-hydroxylation or 27-hydroxylation in the metabolism of cholesterol ...
Norlin, Maria
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Dual-color bioluminescent assay using infected HepG2 cells sheds new light on Chlamydia pneumoniae and human cytomegalovirus effects on human cholesterol 7α-hydroxylase (CYP7A1) transcription.

, 2012
Chlamydia pneumoniae and human cytomegalovirus (HCMV) are intracellular pathogens able to infect hepatocytes, causing an increase in serum triglycerides and cholesterol levels due to the production of inflammatory cytokines. We investigated whether these
RODA, ALDO, ALDINI, RITA, MONTAGNANI, MARCO, Zvi IB, CEVENINI, LUCA, NARDINI, PAOLA, MEZZANOTTE, LAURA, DONATI, MANUELA, MICHELINI, ELISA, MARANGONI, ANTONELLA, FOSCHI, CLAUDIO, Cevenini M, CEVENINI, ROBERTO   +12 more
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Bile Acid Homeostasis in a Cholesterol 7α-Hydroxylase and Sterol 27-Hydroxylase Double Knockout Mouse Model. [PDF]

Hepatology, 2019
Rizzolo D, Buckley K, Kong B, Zhan L, Shen J, Stofan M, Brinker A, Goedken M, Buckley B, Guo GL.   +9 more
europepmc   +1 more source

Studies on cholesterol 7alpha-hydroxylase.

, 2018
The conversion of cholesterol into bile acids in the liver forms a major pathway of cholesterol catabolism and elimination in mammals. The main rate-limiting enzyme of this pathway, cholesterol 7alpha-hydroxylase, is a microsomal enzyme which displays ...
Rush, W. Roger.
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Cholesterol 7α-hydroxylase-deficient mice are protected from high-fat/high-cholesterol diet-induced metabolic disorders. [PDF]

J Lipid Res, 2016
Ferrell JM, Boehme S, Li F, Chiang JY.
europepmc   +1 more source

Suppression of sterol 27-hydroxylase mRNA and transcriptional activity by bile acids in cultured rat hepatocytes

, 1995
In previous work we have demonstrated suppression of cholesterol 7α-hydroxylase by bile acids at the level of mRNA and transcription, resulting in a similar decline in bile acid synthesis in cultured rat hepatocytes.
Twisk, J., Wit, E.C.M. de, Princen, H.M.G.   +2 more
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