Results 101 to 110 of about 6,635 (224)

Cholesterol, bile acid, and lipoprotein metabolism in two strains of hamster, one resistant, the other sensitive (LPN) to sucrose-induced cholelithiasis1

Journal of Lipid Research, 2000
A comprehensive study of cholesterol, bile acid, and lipoprotein metabolism was undertaken in two strains of hamster that differed markedly in their response to a sucrose-rich/low fat diet.
Jacqueline Férézou, Murielle Combettes-Souverain, Maâmar Souidi, Jeffery L. Smith, Nathalie Boehler, Fabien Milliat, Erik Eckhardt, Géraldine Blanchard, Michel Riottot, Colette Sérougne, Claude Lutton   +10 more
doaj   +1 more source

The Effect of Chlorella vulgaris Supplementation on Liver Enzymes, Serum Glucose and Lipid Profile in Patients with Non-Alcoholic Fatty Liver Disease [PDF]

, 2014
Background: Non-alcoholic fatty liver disease (NAFLD) is becoming a public health problem worldwide and using microalgae is a new approach on its treatment.
Mehrangiz Ebrahimi-Mameghani, Mohammad AsghariJafarabadi, Soodabeh Aliashrafi, Yousef Javadzadeh   +3 more
core   +1 more source

Glucose stimulates cholesterol 7α-hydroxylase gene transcription in human hepatocytes[S]

Journal of Lipid Research, 2010
Bile acids play important roles in the regulation of lipid, glucose, and energy homeostasis. Recent studies suggest that glucose regulates gene transcription in the liver.
Tiangang Li, Dipanjan Chanda, Yanqiao Zhang, Hueng-Sik Choi, John Y.L. Chiang   +4 more
doaj   +1 more source

Pengaruh Pemberian Jus Pare (Momordica Charantia L.) Dan Jus Jeruk Nipis (Citrus Aurantifolia) Terhadap Kadar Kolesterol Total Tikus Sprague Dawley Hiperkolsterolemia [PDF]

, 2014
Latar Belakang : Hiperkolesterolemia merupakan faktor utama dan faktor risiko independen penyakit kardiovaskuler. Penurunan kolesterol total merupakan salah satu strategi dalam terapi penyakit kardiovaskuler.
Isnawati, M. (Muflidah), Purnamasari, A. W. (Aresta)   +1 more
core  

The Use of Isomeric Testosterone Dimers to Explore Allosteric Effects in Substrate Binding to Cytochrome P450 CYP3A4 [PDF]

, 2016
: Cytochrome P450 CYP3A4 is the main drug-metabolizing enzyme in the human liver, being responsible for oxidation of 50% of all pharmaceuticals metabolized by human P450 enzymes.
Bastien, Dominic, Bérubé, Gervais, Denisov, Ilia G., Grinkova, Yelena V., Kincaid, James R., Mak, Piotr J., Sligar, Stephen G.   +6 more
core   +2 more sources

CYP7A1 promoter polymorphism −203A>C affects bile salt synthesis rate in patients after ileal resection

Journal of Lipid Research, 2008
Cholesterol 7α-hydroxylase (CYP7A1) plays a crucial role in cholesterol metabolism and has been implicated in genetic susceptibility to atherosclerosis. Thus, an understanding of its transcriptional regulation is of considerable importance.
Martin Leníček, Viktor Komárek, Miluše Zimolová, Jan Kovář, Milan Jirsa, Milan Lukáš, Libor Vítek   +6 more
doaj   +1 more source

Bile acids and cytokines inhibit the human cholesterol 7α‐hydroxylase gene via the JNK/c‐jun pathway in human liver cells† [PDF]

, 2006
Tiangang Li, Asmeen Jahan, John Y.L. Chiang   +2 more
openalex   +1 more source

Inhibition of 7α,26-dihydroxycholesterol biosynthesis promotes midbrain dopaminergic neuron development

iScience
Summary: Dysregulated cholesterol metabolism has been linked to neurodegeneration. We previously found that free, non-esterified, 7α,(25R)26-dihydroxycholesterol (7α,26-diHC), was significantly elevated in the cerebrospinal fluid of patients with ...
James Hennegan, Aled H. Bryant, Lauren Griffiths, Matthieu Trigano, Oliver J.M. Bartley, Joanna J. Bartlett, Carys Minahan, Willy Antoni Abreu de Oliveira, Eylan Yutuc, Sotirios Ntikas, Christos S. Bartsocas, Margarita Markouri, Eleni Antoniadou, Ioanna Laina, Owain W. Howell, Meng Li, Yuqin Wang, William J. Griffiths, Emma L. Lane, Mariah J. Lelos, Spyridon Theofilopoulos   +20 more
doaj   +1 more source

Monitoring hepatic cholesterol 7α-hydroxylase activity by assay of the stable bile acid intermediate 7α-hydroxy-4-cholesten-3-one in peripheral blood

Journal of Lipid Research, 2003
We describe an accurate method for monitoring the enzymatic activity of hepatic cholesterol 7α-hydroxylase (C7αOH; CYP7A1), the rate-limiting and major regulatory enzyme in the synthesis of bile acids.
Cecilia Gälman, Ingela Arvidsson, Bo Angelin, Mats Rudling   +3 more
doaj   +1 more source

Overexpression of Cholesterol 7α-Hydroxylase Promotes Hepatic Bile Acid Synthesis and Secretion and Maintains Cholesterol Homeostasis Δ [PDF]

, 2010
Tiangang Li, Michelle Matozel, Shannon Boehme, Bo Kong, Lisa Nilsson, Grace L. Guo, Ewa Ellis, John Y.L. Chiang   +7 more
openalex   +1 more source