Results 31 to 40 of about 6,635 (224)

Cholecystectomy prevents expansion of the bile acid pool and inhibition of cholesterol 7α-hydroxylase in rabbits fed cholesterol

Journal of Lipid Research, 2001
To study the effect of cholecystectomy on the regulation of classic and alternative bile acid syntheses, gallbladder-intact (n = 20) and cholecystectomized (n = 20) New Zealand White rabbits were fed either chow or chow with 2% cholesterol (3 g/day ...
Guorong Xu, Gerald Salen, Benjamin L. Shneider, M. Ananthanarayanan, Sarah Shefer, Lin Ma, Ashok Batta, Lien B. Nguyen, Josephine J. Lingutla, G. Stephen Tint, Mark Pcolinsky, Frederick J. Suchy   +11 more
doaj   +1 more source

Phospholipids modify substrate binding and enzyme activity of human cytochrome P450 27A1

Journal of Lipid Research, 2004
Cytochrome P450 27A1 (P450 27A1) is an important metabolic enzyme involved in bile acid biosynthesis and the activation of vitamin D3 in mammals.
Dilyara A. Murtazina, Ulla Andersson, In-Su Hahn, Ingemar Bjorkhem, G.A.S. Ansari, Irina A. Pikuleva   +5 more
doaj   +1 more source

Stimulation of cholesterol 7α-hydroxylase by phenobarbital in two strains of rats

Journal of Lipid Research, 1972
The effect of phenobarbital administration on the in vitro activity of cholesterol 7α-hydroxylase was investigated in two strains of rats. In rats of the Wistar strain the daily injection of phenobarbital (100 mg/kg per day ip for 5 days) produced a 33 ...
S. Shefer, S. Hauser, E.H. Mosbach
doaj   +1 more source

Hippocampal 7α-Hydroxylated Neurosteroids Are Raised by Training and Bolster Remote Spatial Memory with Increase of the Spine Densities

iScience, 2020
Summary: Neuroactive steroids, termed neurosteroids, are synthesized locally in the brain and influence biological functions including cognition and behavior.
Kanako Maehata, Kimiko Shimizu, Tomoko Ikeno, Qiuyi Wang, Ayaka Sakurai, Zefeng Wei, Yue Pan, Toshifumi Takao, Yoshitaka Fukada   +8 more
doaj   +1 more source

Quantification of the 15 major human bile acids and their precursor 7α-hydroxy-4-cholesten-3-one in serum by liquid chromatography-tandem mass spectrometry [PDF]

, 2010
Bile acids are increasingly gaining attention since they were discovered to be activators of the transcription factor farnesoid X receptor (FXR) in addition to their well-established role in dietary lipid emulsification.
Alnouti, Ando, Arnold von Eckardstein, Bentayeb, Bjorkhem, Burkard, Camilleri, Carine Steiner, Cariou, Caron, Claudel, DeBarber, Duran-Sandoval, Honda, Karuna, Katharina M. Rentsch, Kuipers, Lefebvre, Lovgren-Sandblom, Makishima, Parks, Sauter, Scherer, Staels, Tagliacozzi, Tessier, Wang, Xiang, Ye, Zhang   +29 more
core   +1 more source

Microbiota and bile acid profiles in retinoic acid-primed mice that exhibit accelerated liver regeneration. [PDF]

, 2015
Background & aimsAll-trans Retinoic acid (RA) regulates hepatic lipid and bile acid homeostasis. Similar to bile acid (BA), RA accelerates partial hepatectomy (PHx)-induced liver regeneration.
Hu, Ying, Liu, Hui-Xin, Wan, Yu-Jui Yvonne   +2 more
core   +2 more sources

Hepatic 7α-hydroxylation of cholesterol in ascorbate-deficient and ascorbate-supplemented guinea pigs

Journal of Lipid Research, 1976
Cholesterol 7α-hydroxylase activity was assayed in liver microsomes from guinea pigs supplemented with ascorbate and from guinea pigs in a state of ascorbate deficiency.
I Björkhem, A Kallner
doaj   +1 more source

On the heterogeneity of the mitochondrial C27-steroid 26-hydroxylase system

Journal of Lipid Research, 1976
Mitochondrial 26-hydroxylation of exogenous cholesterol, endogenous cholesterol, and 5β-cholestane-3α,7α,12α-triol was studied. 26-Hydroxylation of endogenous cholesterol was measured by mass fragmentography.
J Gustafsson
doaj   +1 more source

Alternate pathways of bile acid synthesis in the cholesterol 7α-hydroxylase knockout mouse are not upregulated by either cholesterol or cholestyramine feeding

Journal of Lipid Research, 2001
Bile acids are synthesized via the classic pathway initiated by cholesterol 7α-hydroxylase (CYP7A1), and via alternate pathways, one of which is initiated by sterol 27-hydroxylase (CYP27).
Margrit Schwarz, David W. Russell, John M. Dietschy, Stephen D. Turley   +3 more
doaj   +1 more source

Egy ritka, veleszületett neurodegeneratív betegség: a cerebrotendinosus xanthomatosis laboratóriumi diagnosztikája [PDF]

, 2014
Cerebrotendinous xanthomatosis is a rare neurodegenerative disease characterized by the accumulation of cholesterol and cholestanol in the brain and the tendons caused by mutations of the gene encoding sterol 27-hydroxylase (CYP27A1), which is involved ...
Balogh István, Harangi János, Harangi Mariann, Kapás István, Katkó Mónika, Kovács G. Gábor, Madar László, Molnár Mária Judit, Paragh György, Seres Ildikó, Varga Viktória Evelin   +10 more
core   +1 more source