Results 81 to 90 of about 6,635 (224)

Effect of pregnancy and lactation on lipoprotein and cholesterol metabolism in the rat

Journal of Lipid Research, 1998
Origins of hyperlipidemia and cholestasis that occur during pregnancy were investigated by examining expression of key elements related to plasma and hepatic cholesterol metabolism during pregnancy, lactation, and post-lactation in the rat model.
Jeffery L. Smith, Steven R. Lear, Trudy M. Forte, William Ko, Mara Massimi, Sandra K. Erickson   +5 more
doaj   +1 more source

Macrophage inhibitory cytokine-1 aggravates diet-induced gallstone formation via increased ABCG5/ABCG8 expression.

PLoS ONE, 2023
Macrophage inhibitory cytokine 1 (MIC-1), which is overproduced in various human cancers and associated with cachexia, acts on the hypothalamus to suppress appetite and reduce body weight.
Min Hee Kim, Eun-Ji Lee, Su-Jeong Kim, Yun-Jae Jung, Woo-Jae Park, Inkeun Park   +5 more
doaj   +1 more source

Cyp2c70 is responsible for the species difference in bile acid metabolism between mice and humans [PDF]

, 2016
Bile acids are synthesized from cholesterol in the liver and subjected to multiple metabolic biotransformations in hepatocytes, including oxidation by cytochromes P450 (CYPs) and conjugation with taurine, glycine, glucuronic acid, and sulfate.
Botham, Buffie, C. Roland Wolf, Cen Xie, Chad N. Brocker, Cheng, Cheung, Colin J. Henderson, de Aguiar Vallim, Deo, Dragin, Fedorowski, Frank J. Gonzalez, Gonzalez, Greathouse, Gu, Hardison, Hasegawa, Hirano, Hofmann, Hofmann, Inagaki, Jiang, Jiang, Jones, Katagiri, Kristopher W. Krausz, Li, Löfgren, Matsubara, Mueller, Nelson, Russell, Russell, Sayin, Scheer, Scheer, Scheer, Scheer, Seeley, Shogo Takahashi, Tanaka, Tatsuki Fukami, Thomas, van Herwaarden, Yusuke Masuo   +45 more
core   +2 more sources

Autocrine Netrin‐1 Signaling in Hepatic Stellate Cells Drives Liver Fibrosis and Diet‐Induced Metabolic Dysfunction‐Associated Steatohepatitis in Mice

Advanced Science, Volume 13, Issue 10, 18 February 2026.
Netrin‐1 expression is upregulated in hepatic stellate cells (HSCs) during metabolic dysfunction–associated steatohepatitis and injury‐mediated liver fibrosis. Secreted Netrin‐1 establishes an autocrine positive feedback loop by binding to UNC5B receptors on HSCs.
Jiahui Zhao, Yajie Peng, Hongyan Lei, Tianyi Wang, Huajuan Wang, Bo Wang, Jin Li, Xiaoying Li, Xuelian Xiong   +8 more
wiley   +1 more source

Age-related changes in cholesterol metabolism in macrosomic offspring of rats with streptozotocin-induced diabetes

Journal of Lipid Research, 2001
The aim of this study was to determine the impact of diabetic macrosomia on cholesterol and lipoprotein metabolism. Age-related changes in the activities of serum LCAT, hepatic HMG-CoA reductase, cholesterol 7α-hydroxylase, and ACAT, the major enzymes ...
H. Merzouk, S. Madani, A. Boualga, J. Prost, M. Bouchenak, J. Belleville   +5 more
doaj   +1 more source

Studies on PCSK9 in the regulation of cholesterol metabolism [PDF]

, 2011
Elevated levels of plasma cholesterol, mainly in low density lipoproteins (LDL), are a major risk factor for coronary heart disease. The level of plasma LDL cholesterol (LDL-C) is largely dependent on the number of hepatic LDL receptors (LDLRs ...
Persson, Lena
core   +1 more source

Ginsenoside Rg1 as a Multifunctional Therapeutic Agent: Pharmacological Properties, Molecular Mechanisms and Clinical Perspectives in Complementary Medicine

Food Science &Nutrition, Volume 14, Issue 2, February 2026.
Ginsenoside Rg1 (Rg1) from Panax ginseng shows multifunctional health effects. Although oral bioavailability is low and blood–brain barrier (BBB) penetration is limited, delivery systems such as liposomes and nanoparticles may improve exposure. Rg1 reduces inflammation/oxidative stress by inhibiting nuclear factor‐κB (NF‐κB) signaling and reactive ...
Hernán Cortés, Enrique Lima, Lorena Duarte‐Peña, Sheila I. Peña‐Corona, Zainab M. Almarhoon, Rajesh Kaverikana, Shivaprasad Shetty Mangalpady, Vinayaka Babu Shet, Nikshitha Manjeshwar, Javad Sharifi‐Rad, Jen‐Tsung Chen, Gerardo Leyva‐Gómez, William N. Setzer, Daniela Calina   +13 more
wiley   +1 more source

Studies on cholesterol 7α-Hydroxylase [PDF]

, 1976
Attempts were made to solubilize the enzyme cholesterol 7α-hydroxylase from native rat liver microsomes and from rat liver microsomal acetone and butanol powders.
Hattersley, Neil G.
core  

Effects of Zingiber officinale hydro-alcoholic extract on HMG-COA reductase level in the testis of streptozotocininduced diabetic rats [PDF]

, 2018
Introduction: Zingiber officinale Roscoe, commonly known as ginger, is used as a cooking spice and therapeutically for its antioxidant and androgenic activities. We investigated the effects of Z. officinale hydro-alcoholic extract on HMG-CoA (3-hydroxy-
Ahmmadpour, Fatemeh., Kheirollah, Alireza., Lamuchi-Deli, Nasrin., Mohammadzadeh, Ghorban., Moradi-Podeh, Bahman., Payami, Seyede-Arefe.   +5 more
core   +2 more sources

Caloric Restriction and Dietary Taurine Regulate Taurine Homeostasis Through Distinct Tissue‐Specific Mechanisms in Mice

Molecular Nutrition &Food Research, Volume 70, Issue 3, 13 February 2026.
Caloric restriction and dietary taurine each regulate taurine homeostasis independently. The intestinal taurine pool is predominantly affected by synthesis triggered by caloric restriction, whereas hepatic taurine levels vary according to dietary intake.
András Gregor, Arturo Auñon‐Lopez, Qendrim Zebeli, Marc Pignitter, Kalina Duszka   +4 more
wiley   +1 more source