Results 1 to 10 of about 74,180 (357)

Cellular Cholesterol Efflux Mediated by Cyclodextrins [PDF]

Journal of Biological Chemistry, 1995
In this study, we compared cholesterol efflux mediated by either high density lipoproteins (HDL3) or beta-cyclodextrins, cyclic oligosaccharides that are able to dissolve lipids in their hydrophobic core. beta-Cyclodextrin, 2-hydroxypropyl-beta-cyclodextrin, and methyl-beta-cyclodextrin at 10 mM induced the release of 50-90% of L-cell [3H]cholesterol ...
Elisabeth P.C. Kilsdonk, Patricia G. Yancey, Genevieve Stoudt, Faan Wen Bangerter, William J. Johnson, Michael C. Phillips, George H. Rothblat   +6 more
openalex   +6 more sources

Cholesterol efflux mediated by apolipoproteins is an active cellular process distinct from efflux mediated by passive diffusion

Journal of Lipid Research, 1997
It is becoming increasingly accepted that removal of cellular cholesterol occurs by at least two pathways, one involving the well-described aqueous diffusion mechanism and another promoted by lipid-free apolipoproteins.
A J Mendez
doaj   +2 more sources

Cell-surface binding sites for high density lipoproteins do not mediate efflux of cholesterol from human fibroblasts in tissue culture.

Journal of Lipid Research, 1988
The present investigation was designed to test the hypothesis that binding sites for high density lipoproteins (HDL3) on cell surfaces of peripheral tissues mediate cholesterol efflux from these cells.
C M Mendel, S T Kunitake
doaj   +2 more sources

Sterol synthesis is up-regulated in cholesterol-loaded pigeon macrophages during induction of cholesterol efflux

Journal of Lipid Research, 1999
The extent to which cholesterol synthesis is modulated in macrophage foam cells by changes in cholesterol influx and efflux was determined using thioglycollate-elicited peritoneal macrophages from normal and cholesterol-fed White Carneau (WC) and Show ...
Brian K. Nordskog, Jerry W. Reagan, Jr., Richard W. St. Clair   +2 more
doaj   +2 more sources

Inhibition of miR-33a-5p in Macrophage-like Cells In Vitro Promotes apoAI-Mediated Cholesterol Efflux [PDF]

Pathophysiology
Atherosclerosis is caused by cholesterol accumulation within arteries. The intima is where atherosclerotic plaque accumulates and where lipid-laden foam cells reside.
Olanrewaju Oladosu, Emma Chin, Christian Barksdale, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos   +5 more
doaj   +2 more sources

Apolipoproteins, membrane cholesterol domains, and the regulation of cholesterol efflux.

Journal of Lipid Research, 1992
Published data related to both cell membrane biology and apolipoprotein structure are reviewed and used to formulate a new model describing the mechanisms of cholesterol efflux from cell plasma membrane to high density lipoprotein (HDL) particles.
GH Rothblat, FH Mahlberg, WJ Johnson, MC Phillips   +3 more
doaj   +3 more sources

Cholesterol efflux pathways, inflammation, and atherosclerosis [PDF]

Critical Reviews in Biochemistry and Molecular Biology, 2021
Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization studies and the majority of clinical trials not showing any benefit of plasma HDL-cholesterol raising ...
Anouk G. Groenen, Benedek Halmos, Alan R. Tall, Marit Westerterp   +3 more
openaire   +3 more sources

Targeted cholesterol efflux [PDF]

Cell Cycle, 2013
In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in ...
Longhou Fang, Yury I. Miller
openaire   +3 more sources

Cholesterol Efflux Assay [PDF]

Journal of Visualized Experiments, 2012
Cholesterol content of cells must be maintained within the very tight limits, too much or too little cholesterol in a cell results in disruption of cellular membranes, apoptosis and necrosis. Cells can source cholesterol from intracellular synthesis and from plasma lipoproteins, both sources are sufficient to fully satisfy cells' requirements for ...
Anh Hoang, Hann Low, Dmitri Sviridov
openaire   +2 more sources

Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]

PLoS ONE, 2016
Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano, Ikuo Inoue, Yasuhiro Takenaka, Hiraku Ono, Shigehiro Katayama, Takuya Awata, Takayuki Murakoshi   +6 more
doaj   +1 more source