Results 1 to 10 of about 79,855 (290)
E3 ubiquitin ligase Listerin regulates macrophage cholesterol efflux and atherosclerosis by targeting ABCA1 [PDF]
The Journal of Clinical InvestigationAtherosclerosis arises from disrupted cholesterol metabolism, notably impaired macrophage cholesterol efflux leading to foam cell formation. Through single-cell and bulk RNA-Seq, we identified Listerin E3 ubiquitin protein ligase 1 (Listerin) as a ...
Lei Cao +17 more
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Targeted cholesterol efflux [PDF]
Cell Cycle, 2013 In the process of reverse cholesterol transport, high-density lipoprotein (HDL) transports excess cholesterol from peripheral cells back to the liver, where cholesterol is recycled or metabolized and excreted. On the cellular level, 2 membrane-associated ATP-binding cassette (ABC) cholesterol transporters, ABCA1 and ABCG1, play a major role in ...
Fang, Longhou, Miller, Yury I
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Ezetimibe Promotes Brush Border Membrane-to-Lumen Cholesterol Efflux in the Small Intestine. [PDF]
PLoS ONE, 2016 Ezetimibe inhibits Niemann-Pick C1-like 1 (NPC1L1), an apical membrane cholesterol transporter of enterocytes, thereby reduces intestinal cholesterol absorption.
Takanari Nakano +6 more
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Cholesterol Efflux Assay [PDF]
Journal of Visualized Experiments, 2012 Cholesterol content of cells must be maintained within the very tight limits, too much or too little cholesterol in a cell results in disruption of cellular membranes, apoptosis and necrosis. Cells can source cholesterol from intracellular synthesis and from plasma lipoproteins, both sources are sufficient to fully satisfy cells' requirements for ...
Hann, Low, Anh, Hoang, Dmitri, Sviridov
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Cholesterol efflux pathways, inflammation, and atherosclerosis [PDF]
Critical Reviews in Biochemistry and Molecular Biology, 2021 Plasma levels of high-density lipoprotein (HDL) inversely correlate with the incidence of cardiovascular diseases (CVD). The causal relationship between plasma HDL-cholesterol levels and CVD has been called into question by Mendelian randomization studies and the majority of clinical trials not showing any benefit of plasma HDL-cholesterol raising ...
Anouk G. Groenen +3 more
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Arteriosclerosis thrombosis and vascular biology, 2012 Monocytosis and neutrophilia are well-established risk factors for atherosclerosis and seem to play a causative role in lesion development. Studies in mice with defects in cholesterol efflux pathways have identified novel roles for the ATP-binding cassette transporter A1, ATP-binding cassette transporter G1, and apolipoprotein E in suppressing ...
Tall, Alan R +3 more
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New Strategies to Promote Macrophage Cholesterol Efflux
Frontiers in Cardiovascular Medicine, 2021 The capacity of macrophages to dispose of cholesterol deposited in the atherosclerotic plaque depends on their ability to activate cholesterol efflux pathways.
Hong Y. Choi +3 more
doaj +1 more source
A sensitive assay for ABCA1-mediated cholesterol efflux using BODIPY-cholesterol
Journal of Lipid Research, 2011 Studies have shown a negative association between cellular cholesterol efflux and coronary artery disease (CAD). Standard protocol for quantitating cholesterol efflux involves labeling cells with [3H]cholesterol and measuring release of the labeled ...
Sandhya Sankaranarayanan +6 more
doaj +1 more source
Inhibition of cellular cholesterol efflux by 25-hydroxycholesterol.
Journal of Lipid Research, 1995 The effect of oxysterols on efflux of cholesterol from mouse L-cell fibroblasts, rat Fu5AH hepatoma cells, J774 macrophages, and human EA.hy 926 endothelial cells was studied.
E P Kilsdonk +3 more
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Cholesterol Efflux and Reverse Cholesterol Transport [PDF]
, 2014 Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda +5 more
openaire +4 more sources