Results 21 to 30 of about 82,690 (331)

Cholesterol Efflux and Reverse Cholesterol Transport [PDF]

, 2014
Both alterations of lipid/lipoprotein metabolism and inflammatory events contribute to the formation of the atherosclerotic plaque, characterized by the accumulation of abnormal amounts of cholesterol and macrophages in the artery wall. Reverse cholesterol transport (RCT) may counteract the pathogenic events leading to the formation and development of ...
FAVARI, Elda, Chroni, Angelika, Tietge, Uwe J. F, ZANOTTI, Ilaria, Escolà Gil, Joan Carles, BERNINI, Franco   +5 more
openaire   +4 more sources

Reverse Cholesterol Transport Pathway and Cholesterol Efflux in Diabetic Retinopathy [PDF]

Journal of Diabetes Research, 2021
Cholesterol esters, synthesized from cholesterol with long-chain fatty acids, are essential components of plasma lipoproteins and cell membranes that participate in various metabolic processes in the body. Cholesterol can be excreted through the cholesterol reverse transport (RCT) pathway when excessive cholesterol is produced in the extrahepatic cells,
Xinyuan Zhang, Kaiyue Wang, Ling Zhu, Qiyun Wang   +3 more
openaire   +3 more sources

Dissecting the Impact of Vascular Smooth Muscle Cell ABCA1 versus ABCG1 Expression on Cholesterol Efflux and Macrophage-like Cell Transdifferentiation: The Role of SR-BI

Journal of Cardiovascular Development and Disease, 2023
Cholesterol-laden macrophages are recognized as a major contributor to atherosclerosis. However, recent evidence indicates that vascular smooth muscle cells (VSMC) that accumulate cholesterol and transdifferentiate into a macrophage-like cell (MLC ...
Olanrewaju Oladosu, Ikechukwu C. Esobi, Rhonda R. Powell, Terri Bruce, Alexis Stamatikos   +4 more
doaj   +1 more source

Exosomes containing HIV protein Nef reorganize lipid rafts potentiating inflammatory response in bystander cells. [PDF]

, 2019
HIV infection has a profound effect on "bystander" cells causing metabolic co-morbidities. This may be mediated by exosomes secreted by HIV-infected cells and containing viral factors.
Brichacek, Beda, Bukrinsky, Michael, Ditiatkovski, Michael, Dragoljevic, Dragana, Dubrovsky, Larisa, Fu, Ying, Hoang, Anh, Horvath, Anelia, Low, Hann, Meikle, Peter J, Miller, Yury I, Mukhamedova, Nigora, Murphy, Andrew, Ohkawa, Ryunosuke, Pushkarsky, Tatiana, Sviridov, Dmitri   +15 more
core   +3 more sources

Reverse cholesterol transport and cholesterol efflux in atherosclerosis [PDF]

QJM: An International Journal of Medicine, 2005
Reverse cholesterol transport (RCT) is a pathway by which accumulated cholesterol is transported from the vessel wall to the liver for excretion, thus preventing atherosclerosis. Major constituents of RCT include acceptors such as high-density lipoprotein (HDL) and apolipoprotein A-I (apoA-I), and enzymes such as lecithin:cholesterol acyltransferase ...
R, Ohashi, H, Mu, X, Wang, Q, Yao, C, Chen   +4 more
openaire   +2 more sources

Cellular cholesterol efflux is modulated by phospholipid-derived signaling molecules in familial HDL deficiency/Tangier disease fibroblasts

Journal of Lipid Research, 2001
Familial HDL deficiency (FHD) is the heterozygous form of Tangier disease (TD). Mutations of the ABCA1 gene cause FHD and TD. FHD/TD cells are unable to normally efflux cholesterol onto nascent HDL particles, which are rapidly catabolized. TD fibroblasts
Bassam Haidar, Stephanie Mott, Betsie Boucher, Ching Yin Lee, Michel Marcil, Jacques Genest, Jr.   +5 more
doaj   +1 more source

Ursolic acid enhances macrophage autophagy and attenuates atherogenesis [PDF]

, 2016
Macrophage autophagy has been shown to be protective against atherosclerosis. We previously discovered that ursolic acid (UA) promoted cancer cell autophagy.
Fan, Daping, Iwanowycz, Stephen, Leng, Shuilong, Razani, Babak, Saaoud, Fatma, Sergin, Ismail, Wang, Junfeng, Wang, Yuzhen   +7 more
core   +2 more sources

The roles of different pathways in the release of cholesterol from macrophages

Journal of Lipid Research, 2007
Cholesterol efflux occurs by different pathways, including transport mediated by specific proteins. We determined the effect of enriching cells with free cholesterol (FC) on the release of FC to human serum.
Maria Pia Adorni, Francesca Zimetti, Jeffrey T. Billheimer, Nan Wang, Daniel J. Rader, Michael C. Phillips, George H. Rothblat   +6 more
doaj   +1 more source

Robust passive and active efflux of cellular cholesterol to a designer functional mimic of high density lipoprotein

Journal of Lipid Research, 2015
The ability of HDL to support macrophage cholesterol efflux is an integral part of its atheroprotective action. Augmenting this ability, especially when HDL cholesterol efflux capacity from macrophages is poor, represents a promising therapeutic strategy.
Andrea J. Luthi, Nicholas N. Lyssenko, Duyen Quach, Kaylin M. McMahon, John S. Millar, Kasey C. Vickers, Daniel J. Rader, Michael C. Phillips, Chad A. Mirkin, C.Shad Thaxton   +9 more
doaj   +1 more source

Akt inhibition promotes ABCA1-mediated cholesterol efflux to ApoA-I through suppressing mTORC1. [PDF]

PLoS ONE, 2014
ATP-binding cassette transporter A1 (ABCA1) plays an essential role in mediating cholesterol efflux to apolipoprotein A-I (apoA-I), a major housekeeping mechanism for cellular cholesterol homeostasis.
Fumin Dong, Zhongcheng Mo, Walaa Eid, Kevin C Courtney, Xiaohui Zha   +4 more
doaj   +1 more source